Effects of ethanol and GABAB drugs on working memory in C57BL/6J and DBA/2J mice

Escher, Tobie; Mittleman, Guy

doi:10.1007/s00213-004-1875-x

Cited by 34 publications

(19 citation statements)

References 67 publications

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“…Notably, however, an alternative explanation for this pattern of performance is that baclofen directly enhanced learning of the second rule (left/right lever discrimination in Experiment 1 and visual cue discrimination in Experiment 2), rather than facilitating behavioral flexibility per se . Indeed, in rodents, baclofen is reported to enhance performance on delayed response and radial arm maze tasks, and to reverse methamphetamine-induced deficits in object recognition (Arias et al 2009; Escher and Mittleman 2004; Levin et al 2004). Experiment 3 addressed this possibility by evaluating the effects of baclofen on acquisition of the left/right and visual cue discrimination in rats that had not already learned a competing response rule (i.e., when task acquisition did not require a rule shift).…”

Section: Discussionmentioning

confidence: 99%

Effects of acute administration of the GABA(B) receptor agonist baclofen on behavioral flexibility in rats

2016

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RATIONALE The ability to adjust response strategies when faced with changes in the environment is critical for normal adaptive behavior. Such behavioral flexibility is compromised by experimental disruption of cortical GABAergic signaling, as well as in conditions such as schizophrenia and normal aging that are characterized by cortical hyperexcitability. The current studies were designed to determine whether stimulation of GABAergic signaling using the GABA(B) receptor agonist baclofen can facilitate behavioral flexibility. METHODS Male Fischer 344 rats were trained in a set-shifting task in which they learned to discriminate between two response levers to obtain a food reward. Correct levers were signaled in accordance with two distinct response rules (Rule 1: correct lever signaled by a cue light; Rule 2: correct lever signaled by its left/right position). The order of rule presentation varied, but they were always presented sequentially, with the trials and errors to reach criterion performance on the second (set shift) rule providing the measure of behavioral flexibility. Experiments determined the effects of the GABA(B) receptor agonist baclofen (i.p., 0, 1.0, 2.5 and 4.0 mg/kg) administered acutely before the shift to the second rule. RESULTS Baclofen enhanced set-shifting performance. Control experiments demonstrated that this enhancement was not simply due to improved discrimination learning, nor was it due to impaired recall of the initial discrimination rule. CONCLUSIONS The results demonstrate that baclofen can facilitate behavioral flexibility, suggesting that GABA(B) receptor agonists may have utility for treating behavioral dysfunction in neuropsychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Effects of acute administration of the GABA(B) receptor agonist baclofen on behavioral flexibility in rats

2016

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“…Nicotine acts primarily at nACh receptors, whereas ethanol acts on a wide variety of targets that include nAChRs (Bowers et al 2005;Escher and Mittleman 2004;Larsson et al 2002;Melia et al 1996;Meyerhoff et al 2006;Wehner et al 2004;White et al 2000). Thus, ethanol may directly interact with nicotine by altering nAChR function; in support, ethanol stabilizes the open state of nAChRs, producing a twofold leftward shift in the acetylcholine response curve (Forman and Zhou 1999).…”

Section: Discussionmentioning

confidence: 99%

Interactive effects of ethanol and nicotine on learning in C57BL/6J mice depend on both dose and duration of treatment

Gulick

Gould

2007

Psychopharmacology

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Objective and rationale-Alcohol and nicotine are commonly co-abused; one possible explanation for co-abuse is that each drug ameliorates the aversive effects of the other. Both drugs have dose-dependent effects on learning and memory. Thus, this study examined the interactive effects of acute ethanol and acute, chronic, or withdrawal from chronic nicotine on fear conditioning in C57BL/6J mice.Materials and methods-Conditioning consisted of auditory conditioned stimulus-foot-shock unconditioned stimulus pairings. For acute studies, saline or ethanol, then saline or nicotine was administered before training, and saline or nicotine was also administered before testing. For chronic and withdrawal studies, saline or nicotine was administered chronically, and ethanol or saline was administered before training.Results-Acute nicotine (0.09 mg/kg) reversed ethanol-induced deficits (1.0 and 1.5 g/kg) in contextual and cued fear conditioning, whereas a low dose of ethanol (0.25 g/kg) reversed nicotine (6.3 mg kg −1 day −1 ) withdrawal-induced deficits in contextual conditioning. Tolerance developed for the effects of nicotine on ethanol-induced deficits in conditioning and cross-tolerance between chronic nicotine and acute ethanol was seen for the enhancing effects of ethanol on conditioning.Conclusions-The complex and sometimes polar actions of ethanol and nicotine on behavior may contribute to co-abuse of these drugs. Specifically, smoking may initially reduce the aversive effects of ethanol, but tolerance develops for this effect. In addition, low doses of alcohol may lessen nicotine withdrawal symptoms.

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“…Numerous studies have investigated the effects of ETOH administration on animal models of learning and memory. In general, ETOH impairs spatial learning (Givens 1995;Matthews et al 2002;Boulouard et al 2002;Wright et al 2003;Gonenc et al 2005;Rajendran and Spear 2004), working memory (Gibson 1985;Melchior et al 1993;Givens and McMahon 1997;White et al 1997;Escher and Mittleman 2004), and avoidance (Bammer and Chesher 1982;Markel et al 1986;File and Mabbutt 1990;Melis et al 1996;Singh et al 2003) …”

Section: Introductionmentioning

confidence: 98%

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

et al. 2007

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Effects of ethanol and GABAB drugs on working memory in C57BL/6J and DBA/2J mice

Cited by 34 publications

References 67 publications

Effects of acute administration of the GABA(B) receptor agonist baclofen on behavioral flexibility in rats

Effects of acute administration of the GABA(B) receptor agonist baclofen on behavioral flexibility in rats

Interactive effects of ethanol and nicotine on learning in C57BL/6J mice depend on both dose and duration of treatment

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

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