Effects of Estrogens on the Prostate

THOMAS, JOHN A.; KEENAN, EDWARD J.

doi:10.1002/j.1939-4640.1994.tb00409.x

Cited by 24 publications

References 24 publications

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Estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17β‐estradiol and insulin‐like growth factor 1

Zhou

Wang

et al. 2011

Cell Biochemistry & Function

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Estradiol (E₂) and its receptor estrogen receptor alpha (ERα) are implicated in the pathology of stromal-predominant benign prostatic hyperplasia (BPH). Insulin-like growth factor 1(IGF1) is produced primarily by stromal cells in the prostate. Recent study showed that E₂-mediated regulation of IGF1 in mouse uterus requires the DNA binding ability of ERα. However, the crosstalk between ERα and IGF1 in the prostate has not been addressed yet. Therefore, in this study we employed mouse prostatic smooth muscle cells (PSMCs) as a model to demonstrate that E₂ stimulated the proliferation of PSMCs and up-regulated the expression of IGF1 and its receptor IGF1R as well as cyclin D1 in PSMCs, all of which could be inhibited by shRNA-mediated knockdown of ERα. Furthermore, we found that exogenous IGF1 could not promote cell proliferation and cyclin D1 expression in PSMCs subjected to shRNA-mediated knockdown of ERα. Interestingly, blockage of IGF1R by antibody could inhibit E₂-stimulated PSMCs proliferation. Altogether our present study provides the first line of evidence that there is crosstalk between ERα and IGF1 signaling in PSMCs proliferation in which ERα up-regulates the expression of IGF1 and IGF1R, and IGF1 signaling is indispensable to mediate downstream effects of E₂ and ERα.

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Estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17β‐estradiol and insulin‐like growth factor 1

Zhou

Wang

et al. 2011

Cell Biochemistry & Function

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Influence of Sex Hormones on Prostate Volume in Men on Hemodialysis

HAYAMI,

SASAGAWA,

NAKADA

2000

Journal of Andrology

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The relationship between sex hormones and prostate volume in 90 men on hemodialysis and 91 healthy men was investigated. In men on hemodialysis, serum levels of total and free testosterone were significantly reduced compared with the controls (P < .211), whereas the serum estradiol level was significantly elevated in men on hemodialysis (P < .211). However, prostate volumes were not different between the 2 groups. Serum estradiol level correlated with the prostate volume in controls (P < .001), whereas total and free testosterone levels did not correlate with the prostate volume. In men on hemodialysis, serum levels of total and free testosterone and estradiol did not correlate with the prostate volume. The present study suggests that sex hormones do not play important roles in the prostate growth in men on hemodialysis.

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Clinical development plan: (+)-Vorozole

1996

J. Cell. Biochem.

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Effects of Estrogens on the Prostate

Cited by 24 publications

References 24 publications

Estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17β‐estradiol and insulin‐like growth factor 1

Estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17β‐estradiol and insulin‐like growth factor 1

Influence of Sex Hormones on Prostate Volume in Men on Hemodialysis

Clinical development plan: (+)-Vorozole

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