Effects of estrogens and progesterone upon the biosynthesis of melatonin by the pineal gland

Houssay, Alberto B.; Barceló, Ana C.

doi:10.1007/bf02008353

Cited by 51 publications

(20 citation statements)

References 2 publications

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“…The transferase activity at zero time of culture was comparable with that reported by previous workers [2,16,18]. In cultured pineals, the transferase activity was found to increase slightly during the initial period of incubation, and then returned to the zero time level (Fig.…”

Section: Efiects Of Oestradiol On Hydroxyindole-0-methyltransferuse Asupporting

confidence: 90%

“…Hormonal regulation of this enzyme appears to be insignificant (T. Deguchi, personal communication). In contrast, there have been some indications that the activity of hydroxyindole-0-methyltransferase in the pineal in situ may be hormonally controlled, although the results have been conflicting in the sense that both decrease [2,16,171 and increase [18,19] in the transferase activity are attributed to oestradiol.…”

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confidence: 99%

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Enhancement of Hydroxyindole‐O‐Methyltransferase and DNA‐Dependent RNA Polymerase Activities Induced by Oestradiol in Rat Pineals in Culture

Mizobe

Kurokawa

1976

European Journal of Biochemistry

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Hydroxyindole‐O‐methyltransferase and DNA‐dependent RNA polymerase activities were determined in the pineal gland removed from the ovariectomised rat and cultured under various experimental conditions. The transferase activity declined very slowly during 24 h of incubation. 17β‐Oestradiol significantly increased the transferase activity within 2 h after the addition, and the extent of increase was dose‐dependent within the concentration range from 0.1 to 15 nM, being increased by 80% at 15 nM. Enhancement of the transferase activity by oestradiol was abolished not only by inhibitors of protein synthesis (cycloheximide and puromycin), but also by those of RNA synthesis (actinomycin D and α‐amanitin). It was also blocked by clomiphene citrate, an agent which is known to inhibit the binding of steroid hormones to their respective receptors. RNA polymerase activity (forms A and B) declined rapidly during the initial period of pineal culture. Oestradiol (15 nM) increased the RNA polymerase B activity by 50% within 2 h after the addition. The increase was dose‐dependent within the concentration range from 0.1 to 15 nM, and was abolished by clomiphene citrate. The possibility is suggested that the pineal is a target organ of oestradiol, and that the steroid‐induced reaction sequence in the pineal conforms to that is known in other target organs.

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Section: Efiects Of Oestradiol On Hydroxyindole-0-methyltransferuse Asupporting

confidence: 90%

mentioning

confidence: 99%

Enhancement of Hydroxyindole‐O‐Methyltransferase and DNA‐Dependent RNA Polymerase Activities Induced by Oestradiol in Rat Pineals in Culture

Mizobe

Kurokawa

1976

European Journal of Biochemistry

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“…The putative effect of the sex steroids on HIOMT activity is controversial. In female rats, a number of studies reported no effect on HIOMT activity (Yuwiler, 1985(Yuwiler, , 1989Okatani et al, 1998Okatani et al, , 1999, whereas others found various effects Alexander et al, 1970;Houssay and Barcelo, 1972;Nagle et al, 1972;Preslock, 1977). One of the first in vitro studies showed that HIOMT activity in castrated female rats was stimulated (in 2 h) by physiological doses of estradiol, an effect that was abolished in the presence of RNA and protein synthesis inhibitors (Mizobe and Kurokawa, 1976).…”

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confidence: 99%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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“…In female rats hydroxyindole-O-methyltransferase (HIOMT) activity is either enhanced (Houssay & Barcelo 1972) or depressed (Wurtman et al 1965) by lower or higher dose of estrogen respectively. Other in vitro and in vivo experiments also show that estradiol augments HIOMT (Mizobe & Furokawa 1976) melatonin synthesis resulting in an increase in pineal melatonin content in both rats and guinea pigs (Cardinali et al 1987).…”

Section: Discussionmentioning

confidence: 99%

Steroid hormone and antihormone induced changes in the pineal and adrenocortical karyomorphology and cell proliferation in mice ( Mus musculus )

Bandyopadhyay¹,

Dasgupta²,

Chakraborty³

2010

IJB

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Hormone-induced reponsiveness of the pineal and adrenal glands was studied in post-pubertal male mice (Mus musculus). The influence of steroid hormones (estradiol and testosterone) and non-steroidal antihormones (tamoxifen and flutamide) on pineal and adrenal karyomorphology and cell proliferation activity was analyzed. Estradiol was injected at a dose of 5µg, testosterone 100µg, tamoxifen 500µg and flutamide 2mg per 100g body weight administered intramuscularly in all cases for ten consecutive days. Control mice were similarly injected with 0.3ml of peanut oil vehicle intramuscularly for the same duration. The results indicated that, except testosterone, all other treatments with estradiol, tamoxifen and flutamide caused significant hyperactivity in both the pineal and the adrenal glands, associated with significantly increased cell proliferation activity. On the contrary, testosterone administration was inhibitory to pineal -adrenal karyometric and mitotic incidence values. It was concluded that in male post-pubertal mice both pineal and adrenal glands show antagonistic response towards estradiol and testosterone administration. Although tamoxifen showed estrogen agonistic behaviour, flutamide conversely induced pineal and adrenal cytophysiological stimulation. Such stimulatory response was antagonistic to the inhibitory response shown by pineal and adrenal karyomorphology and cell proliferation following testosterone administration.

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Effects of estrogens and progesterone upon the biosynthesis of melatonin by the pineal gland

Cited by 51 publications

References 2 publications

Enhancement of Hydroxyindole‐O‐Methyltransferase and DNA‐Dependent RNA Polymerase Activities Induced by Oestradiol in Rat Pineals in Culture

Enhancement of Hydroxyindole‐O‐Methyltransferase and DNA‐Dependent RNA Polymerase Activities Induced by Oestradiol in Rat Pineals in Culture

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Steroid hormone and antihormone induced changes in the pineal and adrenocortical karyomorphology and cell proliferation in mice ( Mus musculus )

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