Effects of estrogens and progesterone on electrolyte balances in normal dogs

Johnson, J. A.; Davis, JO; Baumber, JS; Schneider, E. G.

doi:10.1152/ajplegacy.1970.219.6.1691

Cited by 41 publications

(22 citation statements)

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“…Ovulatory period shows on salivary magnesium may be related to preovulatory estrogen peak (Goldsmith et al, 1970). It could be related to concurrent luteinizing hormone and follicle stimulating hormone peaks but gonadotropin effect on mineral retention probably requires on active gonad (Johnson et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Salivary Electrolytes during Normal Menstrual Cycle with Special Reference to Ovulation

Alagendran¹,

Archunan²,

Armando³

et al. 2010

American Journal of Applied Sciences

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Abstract:There is evidence to imply that estrogen influences salivary electrolytes activity in women. Problem statement: In this study we investigated changes in sodium, potassium and inorganic phosphorus, calcium and magnesium which related to find out the precise day of ovulation. These changes might help to explain the fluctuation of ovarian hormones such as preovulatory estrogen surge. Approach: Human whole saliva was collected from 48 healthy subjects of women (age range 20-30 years) during reproductive phases of menstrual cycle were assayed using atomic absorption spectrometer and enzyme immune assay. Amongst a range of electrolytes have been identified such as sodium, potassium, inorganic phosphorus and calcium were comparatively found to be higher during ovulatory phase when compared to that of other phases. Changes were attributed to a probable hormonal outcome on salivary composition. Results: Conversely, in other phases (preovulatory and postovulatory) electrolytes activity like magnesium and calcium decreased later, declining significantly (p<0.05). The increase of electrolytes like sodium and potassium in human saliva, during ovulatory phase might be due to the circulation of steroid hormones. Conclusion: Further, the presence of particular salts influence by ovarian hormones like LH and progesterone in ovulatory saliva makes the possibility to expand a sign for spotlight of ovulation by means of noninvasive method.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Salivary Electrolytes during Normal Menstrual Cycle with Special Reference to Ovulation

Alagendran¹,

Archunan²,

Armando³

et al. 2010

American Journal of Applied Sciences

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“…There are several studies showing that higher levels of estrogen are positively correlated with fluid retention as a result of an increased reabsorption of NaCl and water during pre-ovulatory and pre-menstrual periods [17,36]. However there are some contradictory studies, showing no alteration in the excreted urine volume by estrogen [29].…”

Section: Discussionmentioning

confidence: 99%

“…However there are some contradictory studies, showing no alteration in the excreted urine volume by estrogen [29]. The effects of estrogen on fluid retention have been the focus of several studies [17,29,32,36]. Although no previous reports are available regarding the effect of sex hormones on the expression of Cl channels in the kidney, these hormones have marked effects on CFTR expression in the lung [33,35] and epithelial uterine cell lines [31], showing that a combined treatment with progesterone and estradiol increased CFTR mRNA levels in lungs of immature female rats.…”

Section: Discussionmentioning

confidence: 99%

“…Several investigators have shown that estrogen is associated with a decrease in urinary excretion of sodium and chloride leading to water body retention and a consequent increase in body weight [4,23,32,40]. Those findings were documented in experiments performed on women taking oral contraceptives, as well as in rats, dogs and rabbits treated with estrogen [17,36]. This phenomenon is associated with an increase in renal reabsorption of sodium and chloride from both proximal and distal nephrons; however, the exact mechanisms involved have not yet been identified [4].…”

Section: Introductionmentioning

confidence: 90%

“…It is well known that estrogen administration can lead to significant body fluid retention [17,18] and in very high doses it can cause hypertension [23,40]. Several investigators have shown that estrogen is associated with a decrease in urinary excretion of sodium and chloride leading to water body retention and a consequent increase in body weight [4,23,32,40].…”

Section: Introductionmentioning

confidence: 99%

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Estrogen modulates ClC-2 chloride channel gene expression in rat kidney

Nascimento

Reis

Goldenberg

et al. 2003

Pflugers Arch - Eur J Physiol

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ClC-2 is a CLC family member of chloride channels sensitive to changes in cell volume, pH and voltage. The ClC-2 is widely distributed along the nephron although in the kidney its role still not well understood. Aldosterone studies suggest that ClC-2 expression in the kidney may be hormonally regulated. To explore the possibility that estrogen control ClC-2 expression, we investigated whether its expression changed in the kidney of female Wistar rats subjected to ovariectomy with or without near-physiological or high doses of 17beta-estradiol benzoate treatment for 10 days. Total RNA isolated from rat kidney and dissected nephron segments was analyzed by ribonuclease protection assay and/or a semi-quantitative RT-PCR. The renal ClC-2 protein expression was analyzed by Western blot. The decreased renal expression of ClC-2 mRNA and protein observed in ovariectomized rats was restored to control levels after treatment with low doses of estradiol. Higher dose estradiol lead to an even greater increase in ClC-2 mRNA and protein expression. This change in overall expression was shown to be caused by the modulation of ClC-2 mRNA expression in the proximal tubule. These results suggest that ClC-2 may be involved in estrogen-induced Cl(-) transport in rat kidney.

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Response of primary rabbit kidney proximal tubule cells to estrogens

1999

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The effects of estrogens on the growth and function of primary rabbit kidney proximal tubule (RPT) cells have been examined in hormonally defined phenol red-free medium. 17beta-estradiol was observed to stimulate growth at dosages as low as 10(-10) M. The growth stimulatory effects of 17beta-estradiol were mitigated in the presence of hydrocortisone, suggesting that these two steroid hormones acted at least in part by common mechanisms. The effects of other steroids known to interact with the estrogen receptor were examined. Alpha estradiol was found to be growth stimulatory over a concentration range of 10(-9) to 10(-8) M, albeit to a lower extent than beta estradiol. In addition, the anti-estrogen tamoxifen was also growth stimulatory (unlike the case with the human mammary tumor cell line MCF-7). The effects of several metabolic precursors of 17beta-estradiol were examined, including testosterone, which was growth stimulatory, and progesterone, which was growth inhibitory. The growth stimulatory effects of 17beta-estradiol, alpha estradiol, and tamoxifen could possibly be explained by their interaction with an estrogen receptor. Indeed, metabolic labelling and immunoprecipitation studies indicated the presence of such an estrogen receptor in the primary cultures. The rate of biosynthesis of the estrogen receptor was found to be affected by the presence of exogenously added 17beta-estradiol. 17beta-estradiol was also observed to increase the activity of two brush border enzymes, alkaline phosphatase and gamma glutamyl transpeptidase, during the growth phase of the primary cultures.

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Effects of estrogens and progesterone on electrolyte balances in normal dogs

Cited by 41 publications

References 0 publications

Evaluation of Salivary Electrolytes during Normal Menstrual Cycle with Special Reference to Ovulation

Evaluation of Salivary Electrolytes during Normal Menstrual Cycle with Special Reference to Ovulation

Estrogen modulates ClC-2 chloride channel gene expression in rat kidney

Response of primary rabbit kidney proximal tubule cells to estrogens

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