Effects of Estrogen on Thermoregulatory Responses in Freely Moving Female Rats

Hosono, Takayoshi; Chen, Xiaoming; Zhang, Y.H.; Kanosue, Kazuyuki

doi:10.1111/j.1749-6632.1997.tb51695.x

Cited by 11 publications

(10 citation statements)

References 6 publications

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“…However, a similar reduction in T b was not observed at 5°C in male rats [20,21]. Hosono et al [8] reported that the T b during a 3-h cold exposure at 4°C was higher in ovariectomized rats with E 2 than in those without E 2 . In addition, the T b in ovariectomized rats with E 2 became higher than the baseline level in association with metabolic heat production.…”

Section: Methodsmentioning

confidence: 73%

“…In our study, the progesterone level in the ovariectomized rats was half that found in the normal rats, which may have resulted in the decreased T b . However, the progesterone level was not determined in the study of Hosono et al [8].…”

Section: Methodsmentioning

confidence: 97%

“…Estrogen replacement is sometimes used as a treatment for hot flush [5]. A number of animal studies using ovariectomized rats with and without estrogen replacement have shown that estrogen has an effect on both autonomic and behavioral thermoregulation [6][7][8]. In contrast, Freedman et al found that the plasma level of estradiol was not different between postmenopausal women with and without hot flush [9], suggesting a lesser involvement of circulating estrogen in this condition.…”

Section: Introductionmentioning

confidence: 92%

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Estrogen modulates central and peripheral responses to cold in female rats

et al. 2009

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The aim of this study was to determine whether estrogen modulates central and peripheral responses to cold in female rats. In ovariectomized female rats with and without administered estrogen [E(2) (+) and E(2) (-), respectively], the counts of cFos-immunoreactive cells in the medial preoptic nucleus (MPO) and dorsomedial hypothalamic nucleus (DMH) in the hypothalamus were greater in the E(2) (+) rats than in the E(2) (-) rats at 5 degrees C. Examination of the response of normal female rats to exposure to 5 degrees C at different phases of the estrus cycle revealed that counts of cFos-immunoreactive cells in the MPO, DMH, and posterior hypothalamus and the level of uncoupling protein 1 mRNA in the brown adipose tissues were greater in the proestrus phase than on day 1 of the diestrus phase. This result was linked to the level of plasma estrogen. The body temperature during cold exposure was higher in the E(2) (+) rats than in the E(2) (-) rats and was also higher in the proestrus phase than on day 1 of the diestrus phase. We conclude that estrogen may affect central and peripheral responses involved in thermoregulation in the cold.

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Section: Methodsmentioning

confidence: 73%

Section: Methodsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 92%

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Estrogen modulates central and peripheral responses to cold in female rats

et al. 2009

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“…Core temperature has been reported to be increased (Hosono et al, 1997a; Marrone et al, 1976), decreased (Wilkinson et al, 1980) or unaffected by estrogen treatment of ovariectomized rats (Hosono et al, 2001; Laudenslager et al, 1980; Williams et al, 2010). In guinea pigs, core temperature is increased by ovariectomy and reduced by treatment with estrogen or a ligand for a membrane-associated estrogen receptor (Roepke et al, 2010).…”

Section: Effects Of Estrogen On Hypothalamic Thermoregulation In Tmentioning

confidence: 99%

Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes

Rance

Dacks

Mittelman-Smith

et al. 2013

Frontiers in Neuroendocrinology

266

191

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Despite affecting millions of individuals, the etiology of hot flushes remains unknown. Here we review the physiology of hot flushes, CNS pathways regulating heat-dissipation effectors, and effects of estrogen on thermoregulation in animal models. Based on the marked changes in hypothalamic kisspeptin, neurokinin B and dynorphin (KNDy) neurons in postmenopausal women, we hypothesize that KNDy neurons play a role in the mechanism of flushes. In the rat, KNDy neurons project to preoptic thermoregulatory areas that express the neurokinin 3 receptor (NK3R), the primary receptor for NKB. Furthermore, activation of NK3R in the median preoptic nucleus, part of the heat-defense pathway, reduces body temperature. Finally, ablation of KNDy neurons reduces cutaneous vasodilatation and partially blocks the effects of estrogen on thermoregulation. These data suggest that arcuate KNDy neurons relay estrogen signals to preoptic structures regulating heat-dissipation effectors, supporting the hypothesis that KNDy neurons participate in the generation of flushes.

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“…Second, we examined the effect of estrogen on operant heat-escape behavior in an apparatus that was also recently developed (5). Preliminary results of the experiments of vasomotion previously appeared in abstract form (9).…”

mentioning

confidence: 99%

Effects of estrogen on thermoregulatory tail vasomotion and heat-escape behavior in freely moving female rats

Hosono

Chen

Miyatsuji

et al. 2001

American Journal of Physiology-Regulatory, Integrative and Comp

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Effects of estrogen on thermoregulatory vasomotion and heat-escape behavior were investigated in ovariectomized female rats supplemented with estrogen (replaced estrogen rats) or control saline (low estrogen rats). First, we measured tail temperature of freely moving rats at ambient temperatures (T(a)) between 13 and 31 degrees C. Tail temperature of the low estrogen rats was higher than that of the replaced estrogen rats at T(a) between 19 and 25 degrees C, indicating that the low estrogen rats exhibit more skin vasodilation than the replaced estrogen rats. There was no significant difference in oxygen consumption and core temperature between the two groups. Second, we analyzed heat-escape behaviors in a hot chamber where rats could obtain cold air by moving in and out of a reward area. The low estrogen rats kept T(a) at a lower level than did the replaced estrogen rats. These results imply that the lack of estrogen facilitates heat dissipation both by skin vasodilation and by heat-escape behavior. Ovariectomized rats may mimic climacteric hot flushes not only for autonomic skin vasomotor activity but also for thermoregulatory behavior.

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Effects of Estrogen on Thermoregulatory Responses in Freely Moving Female Rats

Cited by 11 publications

References 6 publications

Estrogen modulates central and peripheral responses to cold in female rats

Estrogen modulates central and peripheral responses to cold in female rats

Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes

Effects of estrogen on thermoregulatory tail vasomotion and heat-escape behavior in freely moving female rats

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