Effects of Estrogen on Fracture Healing in Mice

Beil, Frank Timo; Barvencik, Florian; Gebauer, Matthias; Seitz, Sebastian; Rueger, Johannes M.; Ignatius, Anita; Pogoda, Pia; Schinke, Thorsten; Amling, Michael

doi:10.1097/ta.0b013e3181c4544d

Cited by 67 publications

(90 citation statements)

References 26 publications

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“…The estrogen-deficient state experienced by osteoporotic individuals may adversely affect fracture healing [6]. Furthermore, animal studies suggest the presence of estrogen will enhance fracture healing [31,51,55].…”

Section: Fracture Healingmentioning

confidence: 99%

Sex and Gender Considerations in Male Patients With Osteoporosis

LaMont

Ton

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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Background Osteoporosis remains underrecognized and undertreated in both men and women, but men who sustain fragility fractures experience greater morbidity and mortality. While men exhibit advanced comorbidity at the time of hip fracture presentation, there are distinct sex-and gender-specific factors related to the pathophysiology and treatment of osteoporosis that further influence morbidity and mortality. Questions/purposes With a selective review of the literature, we evaluated sex-and gender-based differences contributing to increased morbidity and mortality in men with osteoporosis.

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Section: Fracture Healingmentioning

confidence: 99%

Sex and Gender Considerations in Male Patients With Osteoporosis

LaMont

Ton

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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“…Estrogen is an important regulator of skeletal growth, development and maintenance [5], and it can enhance the fracture healing in mice [6]. There are two main estrogen receptor (ER) subtypes, denoted ERalpha and ERbeta [7,8].…”

Section: Introductionmentioning

confidence: 99%

Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model

Liu

Pan

et al. 2011

Osteoporos Int

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“…Although both drugs increased trabecular density and enhanced callus biomechanics, raloxifene increased total callus formation, while estrogen specifically increased endosteal bone formation [87]. In the same mouse model, estrogen and raloxifene yielded calluses with larger chondrocyte areas, greater mineralization, increased trabecular and neocortical thickness, and decreased time to fracture healing compared to controls [88,89]. The treated calluses also had significantly increased force to failure and increased stiffness.…”

Section: Animal Studiesmentioning

confidence: 91%

Effect of osteoporosis medications on fracture healing

et al. 2015

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Antiosteoporotic medications are often used to concurrently treat a patient's fragility fractures and underlying osteoporosis. This review evaluates the existing literature from animal and clinical models to determine these drugs' effects on fracture healing. The data suggest that these medications may enhance bone healing, yet more thorough prospective studies are warranted. Pharmacologic agents that influence bone remodeling are an essential component of osteoporosis management. Because many patients are first diagnosed with osteoporosis when presenting with a fragility fracture, it is critical to understand how osteoporotic medications influence fracture healing. Vitamin D and its analogs are essential for the mineralization of the callus and may also play a role in callus formation and remodeling that enhances biomechanical strength. In animal models, antiresorptive medications, including bisphosphonates, denosumab, calcitonin, estrogen, and raloxifene, do not impede endochondral fracture healing but may delay repair due to impaired remodeling. Although bisphosphonates and denosumab delay callus remodeling, they increase callus volume and result in unaltered biomechanical properties. Calcitonin increases cartilage formation and callus maturation, resulting in improved biomechanical properties. Parathyroid hormone, an anabolic agent, has demonstrated promise in animal models, resulting in accelerated healing with increased callus volume and density, more rapid remodeling to mature bone, and improved biomechanical properties. Clinical data with parathyroid hormone have demonstrated enhanced healing in distal radius and pelvic fractures as well as postoperatively following spine surgery. Strontium ranelate, which may have both antiresorptive and anabolic properties, affects fracture healing differently in normal and osteoporotic bone. While there is no effect in normal bone, in osteoporotic bone, strontium ranelate increases callus bone formation, maturity, and mineralization; forms greater and denser trabeculae; and improves biomechanical properties. Further clinical studies with these medications are needed to fully understand their effects on fracture healing in order to simultaneously treat fragility fractures and underlying osteoporosis.

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Effects of Estrogen on Fracture Healing in Mice

Abstract: These results indicate that estrogen seems to be an important factor in all stages of fracture healing. The application of estrogens enhances fracture healing of long bones at least in mice.

Cited by 67 publications

References 26 publications

Sex and Gender Considerations in Male Patients With Osteoporosis

Sex and Gender Considerations in Male Patients With Osteoporosis

Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model

Effect of osteoporosis medications on fracture healing

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