Effects of estradiol on the cognitive function of postmenopausal women

Marinho, Ricardo Mello; Soares, José Maria; Santiago, Ricardo Cabral; Maganhin, Carla Cristina; Machado, Flávia Ribeiro; Cota, Ana Márcia de Miranda; Baracat, Edmund Chada

doi:10.1016/j.maturitas.2008.07.003

Cited by 15 publications

(16 citation statements)

References 25 publications

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“…Women tested behaviourally in the follicular and/or luteal phase, with respectively high levels of estradiol and/or estradiol and progesterone, are less lateralized as compared to the menstrual phase [48]–[51], and also show reduced functional connectivity between hemispheres [52]–[56]. In addition, estradiol appears to modulate cognitive control as assessed by cognitive inhibition [57], [58] and working memory tasks [59]–[61]. One of these studies [60] also showed that this estradiol-related modulation occurred in prefrontal and parietal regions.…”

Section: Introductionmentioning

confidence: 98%

Resting States Are Resting Traits – An fMRI Study of Sex Differences and Menstrual Cycle Effects in Resting State Cognitive Control Networks

et al. 2014

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To what degree resting state fMRI is stable or susceptible to internal mind states of the individual is currently an issue of debate. To address this issue, the present study focuses on sex differences and investigates whether resting state fMRI is stable in men and women or changes within relative short-term periods (i.e., across the menstrual cycle). Due to the fact that we recently reported menstrual cycle effects on cognitive control based on data collected during the same sessions, the current study is particularly interested in fronto-parietal resting state networks. Resting state fMRI was measured in sixteen women during three different cycle phases (menstrual, follicular, and luteal). Fifteen men underwent three sessions in corresponding time intervals. We used independent component analysis to identify four fronto-parietal networks. The results showed sex differences in two of these networks with women exhibiting higher functional connectivity in general, including the prefrontal cortex. Menstrual cycle effects on resting states were non-existent. It is concluded that sex differences in resting state fMRI might reflect sexual dimorphisms in the brain rather than transitory activating effects of sex hormones on the functional connectivity in the resting brain.

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Section: Introductionmentioning

confidence: 98%

Resting States Are Resting Traits – An fMRI Study of Sex Differences and Menstrual Cycle Effects in Resting State Cognitive Control Networks

et al. 2014

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“…Hypoestrogenism after menopause is responsible for bone loss, atrophy of the genitals, vasomotor symptoms such as hot flushes and a decrease in cognitive function 6 . Therefore, hormone therapy (HT) is important to ameliorate the symptoms during this period 7,8 and, since it is now possible to individualize the type of HT, there are fewer resultant side-effects 9 .…”

Section: Introductionmentioning

confidence: 99%

Hormone therapy in Brazilian postmenopausal women with chronic hepatitis C: a pilot study

Pádua

Fonseca²,

Deguti

et al. 2010

Climacteric

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“…A mulher apresenta então aumento da modulação e da sensibilidade simpática, bem como diminuição parassimpática, após a menopausa 36,37,38 . As alterações bioquímicas e de neurotransmissores no SNC, serotoninérgicas e noradrenérgicas, levam à disfunção na área termorreguladora e autonômica no hipotálamo 7,39 Alguns investigadores sugeriram o uso destes termos e o abandono das denominações perimenopausa e climatério 3,46,47 . O climatério durante muito tempo foi definido como período de transição da fase reprodutiva da vida da mulher para a senectude.…”

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“…Esse, sofre influência das alterações hormonais característicos desta fase de vida, em especial hipoestrogenismo 13,54 . Esse hipoestrogenismo induz modificações em diversos órgãos e sistemas, decorrentes de mudanças em células epiteliais, de colágeno e neurotransmissores 16,22,39 .…”

Section: Pós-menopausa E Sintomas Menopausaisunclassified

Modulação autonômica da frequência cardíaca e risco cardiovascular em mulheres na pós-menopausa

Norberto¹

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Introduction: Women in early and late postmenopausal have clinical differences, such as menopause time and symptoms intensity, which influence the autonomic modulation of heart rate and cardiovascular risk. Heart rate variability and Framingham cardiovascular risk are clinical assessment tools for managing this risk. The Framingham risk score is known to have some inconsistencies for this population. However, there is a lack in the literature about autonomic modulation of heart rate associated with Framingham in postmenopausal women. Objective: To evaluate the autonomic modulation of heart rate and cardiovascular risk in early and late postmenopausal women.

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Effects of estradiol on the cognitive function of postmenopausal women

Cited by 15 publications

References 25 publications

Resting States Are Resting Traits – An fMRI Study of Sex Differences and Menstrual Cycle Effects in Resting State Cognitive Control Networks

Resting States Are Resting Traits – An fMRI Study of Sex Differences and Menstrual Cycle Effects in Resting State Cognitive Control Networks

Hormone therapy in Brazilian postmenopausal women with chronic hepatitis C: a pilot study

Modulação autonômica da frequência cardíaca e risco cardiovascular em mulheres na pós-menopausa

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