Effects of estradiol and progesterone on the cytodifferentiation of epithelial cells in the oviduct of the newborn golden hamster

Abé, Hiroyuki; Oikawa, Taneaki

doi:10.1002/ar.1092350308

Cited by 34 publications

(27 citation statements)

References 26 publications

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“…Thus, consistent with previous reports of foxj1 function and the absence of cilia in the oviduct in foxj1 null mice, our findings indicate a key role for foxj1 in the ciliogenesis of the oviduct. Also considered were previous reports that indicated that estrogen signaling may be critical for ciliogenesis, thereby suggesting that E2 could activate foxj1 (Anderson & Hein 1976, Eroschenko 1982, Jansen 1984, Abe & Oikawa 1993, Comer et al 1998.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, the differentiation of the secretory epithelial cell phenotype to the ciliated epithelial cell phenotype can be induced by E2 in primary cultured human fallopian tube epithelial cells (Comer et al 1998). In addition, the appearance of oviductal epithelial cilia, typically observed at day 5 after birth (Komatsu & Fujita 1978), can be accelerated by treatment with E2 in neonatal mouse and hamster oviducts (Eroschenko 1982, Abe & Oikawa 1993. Thus E2 must activate critical pathways required for ciliated epithelial cell differentiation in the oviduct.…”

Section: Introductionmentioning

confidence: 99%

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Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct

Okada¹,

Ohta²,

Brody³

et al. 2004

Journal of Molecular Endocrinology

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Estrogen regulates proliferation and differentiation of epithelial cells in the mammalian oviduct, but pathways for cell-specific differentiation are not well understood. In the epithelial cells of the developing rat oviduct, we found estrogen receptor (ER) is expressed at birth and persists in all cells through neonatal day (ND) 7 when ciliated cells appear. To determine a specific function of ER and foxj1, a transcription factor known to have fundamental roles in ciliogenesis in the lung, in differentiation of the ciliated epithelial cells, we treated newborn rats from ND 0 to 5 with estradiol-17 (E2) with and without a selective ER antagonist. E2 enhanced the number of proliferating cells and accelerated the process of epithelial cell differentiation resulting in ciliogenesis by ND 5, and co-treatment with an ER antagonist inhibited these changes. Foxj1 was expressed only in the infundibulum and ampulla (INF/AMP). That expression preceded the appearance of cilia and was induced by E2. Cilia were absent in oviducts of foxj1-deficient mice, indicating that foxj1 plays a critical role in oviductal ciliogenesis. However, we found the presence of cilia in the ER -deficient mouse oviduct. The widespread expression of ER in oviductal epithelium, but restriction of cilia to the INF/AMP regions, and importantly, the presence of cilia in the ER -deficient mice, suggested ER signaling is not essential for ciliated epithelial cell differentiation. These observations demonstrate that, although E2 stimulates the differentiation process of ciliated epithelial cells, foxj1 is directly required for epithelial cell ciliogenesis of the neonatal oviduct.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct

Okada¹,

Ohta²,

Brody³

et al. 2004

Journal of Molecular Endocrinology

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“…While the proportion of ciliated cells gradually decreases from the ampulla to the isthmus, the secretory cells are well distributed throughout the oviductal ampulla in higher mammals (Fredericks, 1986;Hunter, 1988;Brenner and Maslar, 1988). During the ovarian cycle (Fredericks, 1986;Verhage et al, 1979;Verhage and Jaffe, 1986) or in response to exogenous estradiol (Verhage et al, 1973;Verhage and Brenner, 1975;Odor et al, 1980;Bareither and Verhage, 1981; Abe and Oikawa, 1993) the secretory cells undergo marked ultrastructural modifications associated with changes in secretory activities. While most proteins in the oviductal fluid are serum derived (Leese, 1988), some originate from the oviductal secretory cells.…”

mentioning

confidence: 99%

Oviductins possess chitinase‐ and mucin‐like domains: A lead in the search for the biological function of these oviduct‐specific ZP‐associating glycoproteins

Malette

Paquette

Merlen

et al. 1995

Molecular Reproduction Devel

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Over the last 10 years considerable progress has been made in the immunological and biochemical characterization of oviduct-specific glycoproteins. It is now well established that a subclass of these secretory products, designated as oviductins, associate with the zona pellucida of the ovulated oocyte and with the early embryo. Recent reports on the cloning of cDNAs of oviductins from various species, including that of golden hamster (Mesocricetus auratus) oviductin by our laboratory, allowed us to compare their deduced amino acid sequences with those of other proteins. Optimal alignment analysis showed that oviductins contain regions of significant similarity with catalytically inactive mammalian members of the bacterial and microfilarial chitinase protein family. Most importantly, a close examination of the hamster and human deduced amino acid sequences revealed that both glycoproteins possess contiguous Ser/Thr rich repeated units, clustered in their carboxy-terminal portions. These mucin-type motifs are similar in the hamster and human glycoprotein, although hamster oviductin contains more of these complete units. This striking feature might indicate that these molecules play a similar role to mucin-type glycoproteins, e.g., in protecting the oocyte and early embryo against attacks from their environment. W e propose a model whereby oviductins are targeted to the oocyte via the interaction of their chitinase-like domains with specific oligosaccharide moieties of the zona pellucida. Once localized to this structure, oviductin molecules would act as a protective shield around the oocyte and early embryo by virtue of their densely glycosylated mucin-type domains. o 1995 Wiley-Liss, Inc.

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“…Depending on the oviductal region, there are at least two types of epithelial cells: ciliated epithelial cells and nonciliated or secretory epithelial cells. Growth and development of these cell types are under regulation by the sex steroid hormones E2 and P4 (Abe and Oikawa, 1993). ERα and ERβ expression in the rat oviduct has been reported (Saunders et al, 1997;Sar and Welsch, 1999;Iwanaga, 2000a, 2000b;Wang et al, 2000), but the predominant ERα expression was shown in the neonatal oviduct.…”

Section: During Neonatal Development Of the Oviductmentioning

confidence: 99%

“…Neonatal development of oviductal epithelial cells is regulated by E2 and P4 (Abe and Oikawa, 1993). Neonatal PR-A+B ontogeny in oviduct has been reported in mice (Li, 1994) and rats (Okada et al, 2003).…”

Section: During Neonatal Development Of the Oviductmentioning

confidence: 99%

Sex Steroid Hormone Receptors in the Developing Female Reproductive Tract of Laboratory Rodents

Okada¹,

Satō

Ohta

et al. 2005

J. Toxicol. Sci.

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-Many chemicals released into the environment potentially disrupt the endocrine system in wildlife and humans. Some of these chemicals exhibit estrogenic activity by binding to the estrogen receptors. The developing organism is particularly sensitive to estrogenic chemicals during the critical period in which the induction of long-term changes and persistent molecular alterations in female reproductive tracts occur. Perinatal mouse and rat models can be utilized as indicators for determining the consequences of exposure to exogenous estrogenic agents, including possible xenoestrogens or environmental endocrine disruptors. Estrogen receptors (ER) and estrogen responsive genes, therefore, need to be identified in order to understand the molecular basis of estrogenic actions. Recent identifications of ER subtypes and isoforms make understanding target organ responses to these estrogenic chemicals even more difficult. Indeed, many reports suggest that these chemicals do affect the reproductive and developmental processes of female laboratory rodents that had been perinatally exposed, and that interactions between sex steroid hormone receptors occur. Much information concerning the expression of sex steroid receptors in rodents has been reported concerning the normal development of the Müllerian duct. Thus, accumulated information on the expression of ER subtypes and isoforms as well as that of progesterone and androgen receptors in laboratory rodents is herein reviewed, in addition to the presentation of our own data.

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Effects of estradiol and progesterone on the cytodifferentiation of epithelial cells in the oviduct of the newborn golden hamster

Cited by 34 publications

References 26 publications

Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct

Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct

Oviductins possess chitinase‐ and mucin‐like domains: A lead in the search for the biological function of these oviduct‐specific ZP‐associating glycoproteins

Sex Steroid Hormone Receptors in the Developing Female Reproductive Tract of Laboratory Rodents

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