Effects of estradiol and progesterone on food intake, body weight, and carcass adiposity in weanling rats

Abstract

Schwartz, Susan M., "Effects of estradiol and progesterone on food intake, body weight, and carcass adiposity in weanling rats." (1981 vi

Estrogen Increases c-Fos Expression in the Paraventricular Nucleus along with its Anorexic Effect in Developing Rats

“…In this study, we examined the effect of EB (20 μg/kg) treatment on both food intake and body weight gain in developing rats and demonstrated that estrogen treatment had no effect on food intake in early postnatal days, an observation that is consistent with previous reports [10][11][12]. However, our results indicate that the effect of estrogen treatment appear to become functional around P27 and onwards.…”

“…All pups were subcutaneously (s.c.) injected daily with 20 μg/kg of estradiol benzoate (EB; Sigma, St. Louis, MO, USA) in 50 μl sesame oil (Nacalai Tesque, Kyoto, Japan) or the vehicle alone at 1200 h for three successive days. This dose of EB is enough to decrease food intake in adult rats [24,25] and has no obvious side effect in P25-55 rats [11]. The vagina did not open in the EB-and vehicletreated rats in any of the present experimental groups.…”

“…In nonhuman primates like monkeys, food intake is reduced at the time of ovulation when estrogen is at its peak and increases after ovulation when progesterone is elevated [4]. In rats, food intake is decreased at proestrus when plasma E2 increases during the estrous cycle [5,6], and ovariectomy increases food intake and body weight and E2 treatment normalizes these increases in ovariectomized (OVX) rats [7][8][9].In rats, the anorexic effect of estrogen has been only reported to appear in 45-day-old rats ovariectomized either on the day of birth or at weaning [10,11], and daily treatment of estradiol benzoate (EB) did not decrease food intake or body weight from postnatal day 30 (P30) until approximate P40 in OVX rats [12]. In contrast, the periodic alterations in food intake and meal size have been reported to occur prior to the vaginal opening in intact female rats [13], suggesting that the anorexic effect of estrogen appears prior to puberty in intact rats.…”

“…In rats, the anorexic effect of estrogen has been only reported to appear in 45-day-old rats ovariectomized either on the day of birth or at weaning [10,11], and daily treatment of estradiol benzoate (EB) did not decrease food intake or body weight from postnatal day 30 (P30) until approximate P40 in OVX rats [12]. In contrast, the periodic alterations in food intake and meal size have been reported to occur prior to the vaginal opening in intact female rats [13], suggesting that the anorexic effect of estrogen appears prior to puberty in intact rats.…”

Evaluation of Anti-obesity Effect of Fattolin, a Polyherbal Formulation in Progesterone Induced Obesity in Mice

“…In the present study, subcutaneous administration of progesterone produced significant increase in food intake and thereby body weight in agreement with previous reports. 31 We have observed significantly decreased food intake and body weight in mice treated with Fattolin at dose level of 200 mg/kg and 400 mg/kg. The effect of Fattolin on food intake is mainly due to its active principles which have been reported for various therapeutic effects like hypo lipidaemia, thermo genesis and carminative.…”