Effects of essential oils on symptoms and course (duration and severity) of viral respiratory infections in humans: A rapid review

Prall, Sebastian; Bowles, E. Joy; Bennett, Kathleen; Cooke, Carolyn Giselle; Agnew, Tamara; Steel, Amie; Hausser, Tina

doi:10.1016/j.aimed.2020.07.005

Cited by 13 publications

(7 citation statements)

References 8 publications

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“…Clinical studies have shown that the oral administration of EOs from Lavandula latifolia reduce the symptoms of acute respiratory infections by viruses belonging to the Coronaviridae family. In fact, the treatment of patients with Tavipec ® capsules, providing 900 mg of EO from the flowering tops and stems of spike lavender, allowed the observation of an improvement in the symptoms of acute rhinosinusitis and a decrease in the symptoms of acute bronchitis versus a placebo [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Lavandula austroapennina: Assessment of the Antiviral Activity of Lipophilic Extracts from Its Organs

Chianese

Gravina

Morone

et al. 2023

Viruses

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In a framework aimed at the recovery and enhancement of medicinal plants endemic to the territory of the Cilento and Vallo di Diano National Park, Lavandula austroapennina N.G. Passal., Tundis and Upson has aroused interest. An insight into the chemical composition of the corolla, calyx, leaf, stem, and root organs was carried out following ultrasound-assisted maceration in n-hexane. The obtained lipophilic extracts were explored using ultra-high-performance chromatography coupled to high-resolution mass spectrometry (UHPLC-ESI-QqTOF-MS/MS). The extracts from the different organs varied in their relative content of fatty acids, ursanes, and oleanane-type triterpenes. In particular, the oleanolic acid content appeared to increase in the order of corolla < leaf < stem. An MTT assay was performed to verify the possible cytotoxicity of the organ extracts of L. austroapennina at a concentration ranging from 12.5 to 400 µg/mL on the Vero CCL-81 cell line. Antiviral activity against herpes simplex virus type 1 (HSV-1), alpha human coronavirus 229E (HCoV-229E), and poliovirus type 1 (PV-1) was evaluated via a plaque reduction assay in the same cellular model. All the extracts did not show cytotoxic effects after 2 and 24 h exposure times, and the antiviral efficacy was particularly important for the stem extract, capable of completely inhibiting the tested viruses at low doses. The antiviral activity in a non-enveloped virus PV-1 allowed the assertion that the extracts from the organs of L. austroapennina, and especially the stem extract, interfered directly with the viral envelope. This study underlines how much knowledge of a territory’s medicinal plant heritage is a harbinger of promising discoveries in the health field.

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Section: Discussionmentioning

confidence: 99%

Lavandula austroapennina: Assessment of the Antiviral Activity of Lipophilic Extracts from Its Organs

Chianese

Gravina

Morone

et al. 2023

Viruses

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“…The therapies highlighted in the rapid reviews conducted by the WNF in May 2020 supported the findings of the systematic reviews as of the end of 2022. That is, the most common natural therapies to consider in the prevention and treatment of COVID-19 and post-COVID include Vitamin C, 212 Vitamin D, 213 multivitamins, 214 Zinc, 215 Quercetin, 216 N-Acetyl-cysteine (NAC), 217 essential oils, 218 and the herbs Echinacea, 219 Hedera helix, 220 and Sambucus nigra. 221 Despite the mounting volume of research on natural approaches for the prevention and treatment of COVID-19, there has been limited acknowledgement by or interest from governments with respect to the role of T&CM either adjunctively or individually with respect to the prevention and/or treatment of COVID-19 and/or post-COVID.…”

Section: Growing Interest In the Role Of Nhps And Natural Therapies I...mentioning

confidence: 99%

Interim Report on a Live Review of Systematic Reviews of Natural Health Products and Natural Therapies in the Prevention and/or Treatment of COVID-19

Lloyd

Cooley

Remy

2023

CANDJ

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Objective: This living review of systematic reviews investigates the types and volume of research pertaining to natural health products and therapies as they relate to the prevention and/or treatment of COVID-19 and post-COVID syndrome. Methods: A monthly search for published peer-reviewed systematic reviews of the topic was initiated May 2022 and is ongoing. Using a systematic keyword search strategy with clear inclusion and exclusion criteria, a summary of the types of studies included, the overall outcome and treatment focus were assessed. Results: A total of 225 systematic reviews encompassing 5,636 studies of randomized controlled trials (49.8%, n=112), observational studies (21.3%, n=48), clinical studies (20.4%, n=46), and other studies (12%, n=27) were included. Of those, 28.9% (n=65) of the systematic reviews focused on prevention, 67.6% (n=152) on treatment, and 3.1% (n=8) on post-COVID. The natural health products reviewed included herbal medicine, vitamins, minerals, other natural health products, and other therapies, with 83.5% (n=188) of all systematic reviews stating a positive outcome and beneficial potential of the natural treatment or therapy investigated. Conclusion: This living systematic review concludes that there is a growing interest in research pertaining to natural health products and therapies with respect to the prevention of COVID-19 infections and addressing disease severity and mortality, especially in adjunct to conventional medical intervention. Nonetheless, there is a lack of high-quality evidence and consistency in outcome reporting across the large breadth of natural treatment and management options.

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“…Tea from the peels of Citrus limonum fruits is used as a natural expectorant, which helps in the treatment of flu and viruses that cause the accumulation of secretions in the lungs. Recently, the literature reviewed the essential oils of Citrus limonum ., and reported several therapeutic benefits, including antiviral activity [ 30 ]. To corroborate its empirical use in the Marajó, the literature has already highlighted a role that proves its activity as an expectorant agent [ 31 ].…”

Section: Antiviral Compounds Of Medicinal Plants From Marajómentioning

confidence: 99%

Antiviral Plants from Marajó Island, Brazilian Amazon: A Narrative Review

et al. 2022

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Diseases caused by viruses are a global threat, resulting in serious medical and social problems for humanity. They are the main contributors to many minor and major outbreaks, epidemics, and pandemics worldwide. Over the years, medicinal plants have been used as a complementary treatment in a range of diseases. In this sense, this review addresses promising antiviral plants from Marajó island, a part of the Amazon region, which is known to present a very wide biodiversity of medicinal plants. The present review has been limited to articles and abstracts available in Scopus, Web of Science, Science Direct, Scielo, PubMed, and Google Scholar, as well as the patent offices in Brazil (INPI), United States (USPTO), Europe (EPO) and World Intellectual Property Organization (WIPO). As a result, some plants from Marajó island were reported to have actions against HIV-1,2, HSV-1,2, Sars-CoV-2, HAV and HBV, Poliovirus, and influenza. Our major conclusion is that plants of the Marajó region show promising perspectives regarding pharmacological potential in combatting future viral diseases.

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Effects of essential oils on symptoms and course (duration and severity) of viral respiratory infections in humans: A rapid review

Cited by 13 publications

References 8 publications

Lavandula austroapennina: Assessment of the Antiviral Activity of Lipophilic Extracts from Its Organs

Lavandula austroapennina: Assessment of the Antiviral Activity of Lipophilic Extracts from Its Organs

Interim Report on a Live Review of Systematic Reviews of Natural Health Products and Natural Therapies in the Prevention and/or Treatment of COVID-19

Antiviral Plants from Marajó Island, Brazilian Amazon: A Narrative Review

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