Effects of Esmolol, Lidocaine and Fentanyl on Haemodynamic Responses to Endotracheal Intubation

Uğur, Bakiye; Oğurlu, Mustafa; Gezer, Erdal; Aydın, Osman Nuri; Gürsoy, Feray

doi:10.2165/00044011-200727040-00006

Cited by 65 publications

(45 citation statements)

References 26 publications

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“…In the current study, we determined that esmolol was the most effi cient agent to depress the refl ex response to laryngoscopy and tracheal intubation, in parallel with previous studies 27,32,33 . Prolonged QT interval may cause arrhythmias such as polymorphic ventricular tachycardia or ventricular fi brilation.…”

Section: Discussionmentioning

confidence: 57%

“…However, literature on this matter is confounding. Other studies demonstrated that lidocaine administration before intubation was unable to suppress the laryngoscopy and intubation-related sympathetic activity 27,32,33,38 . In addition, signifi cant MAP increases were observed in lidocaine groups after intubation in Owczuk et al's 17 study, which raises the possibility of insuffi cient lidocaine effi cacy in inhibiting sympathetic activation.…”

Section: Discussionmentioning

confidence: 99%

“…Ugur et al 33 , in their similar study, compared 1.5 mg.kg -1 esmolol, 1 μg.kg -1 fentanyl and 1.5 mg.kg -1 lidocaine with respect to the hemodynamic responses to intubation. They concluded that esmolol administered 2 minutes before intubation was the most effective agent in preventing HR and rate-pressure product increase.…”

Section: Discussionmentioning

confidence: 99%

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Efeitos de esmolol, lidocaína e fentanil nos intervalos dispersão da onda P, QT, QTc e respostas hemodinâmicas à intubação endotraqueal durante indução com propofol: um estudo comparativo

Hancı¹,

Yurtlu²,

Karabağ³

et al. 2013

Rev. Bras. Anestesiol.

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Background and objectives: In our study we aimed to investigate the effect of esmolol, lidocaine and fentanyl on P-wave dispersion (Pwd), QT and corrected QT (QTc) durations and hemodynamic responses to endotracheal intubation during propofol induction. Methods: A total of eighty adult patients, American Society of Anesthesiologists (ASA) Physical Status I or II aged 18 to 60 years were included in this prospective, randomised, double-blind study. All patients had control electrocardiograms (ECGs) done before anesthesia induction. The patients were randomised into four equal groups. The control group (Group C) received saline 5 mL, the esmolol group (Group E) received esmolol 0.5 mg.kg -1 , the fentanyl group (Group F) received fentanyl 2 µg.kg -1 and the lidocaine group (Group L) received lidocaine 1.5 mg.kg -1 before

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Efeitos de esmolol, lidocaína e fentanil nos intervalos dispersão da onda P, QT, QTc e respostas hemodinâmicas à intubação endotraqueal durante indução com propofol: um estudo comparativo

Hancı¹,

Yurtlu²,

Karabağ³

et al. 2013

Rev. Bras. Anestesiol.

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“…[2][3][4][5] Fentanyl is a short acting synthetic opioids agonist 75-125 times more potent than morphine. Several trials have tried varying doses from 2µg/Kg-8 µg/Kg given 1 minute to 10 minutes before intubation.…”

Section: A Comparative Evaluation Of Dexmedetomidine and Fentanyl To mentioning

confidence: 99%

A comparative evaluation of dexmedetomidine and fentanyl to attenuate hemodynamic response to laryngoscopy and intubation

et al. 2018

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A B S T R A C TBackground: Laryngoscopy and intubation are associated with a sympathetically mediated circulatory response due to irritation of respiratory tract which is associated with increase in pulse rate and blood pressure that may be dangerous. Aims and Objectives: The aim of the present study was to determine and compare the efficacy of dexmedetomidine and fentanyl in attenuating the hemodynamic response to laryngoscopy and intubation and to detect any complication or side effect as a result of these drugs. Materials and Methods: Following approval by ethical committee, 60 ASA grade I and II patients of either sex undergoing general anaesthesia for elective surgery were included in this study. Patients were randomly divided into two groups of 30 patients each. Dexmedetomidine in a dose of 1µg/kg was given to Group A patients and Fentanyl 2 µg/kg was given to Group B patients. Both the drugs were diluted with normal saline solution to make 10ml and were administered slow intravenous 10 min before induction.The hemodynamic parameters were recorded, demographic data was analyzed using unpaired t-test and hemodynamic variables were analyzed by using unpaired and paired t-test. Side effects were analyzed using chi square test. Result: The two groups were comparable in their demographic profiles. Dexmedetomidine proved itself to be an excellent drug when given intravenously as a premedicant in dose of 1µg/kg to attenuate hemodynamic response to laryngoscopy and intubation. It blunted the hemodynamic response to laryngoscopy and intubation to a greater magnitude than fentanylin a dose of 2µg/kg intravenously as a premedicant. Conclusion: We conclude that fentanyl 2µg/kg i.v. given ten minutes prior to airway instrumentation shows an inconsistent response to laryngoscopy and intubation. Between the two drugs under study, the use of dexmedetomidine 1µg/kg i.v. is satisfactory and produces a more favorable hemodynamic profile while fentanyl 2µg/kg is found to be non-dependable and less effective for the attenuation of the pressor response to laryngoscopy and endotracheal intubation. However, further larger studies are required to strengthen these conclusions.

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“…[1][2][3][4][5][6][7] Thus different drugs such as local anesthetics, opioids, calcium channel blockers, short acting β-adrenergic blockers, and their combinations have been used to prevent this hemodynamic responses but none was found to be most effective. [8][9][10][11][12][13][14] Fentanyl, a commonly used opioid along with hypnotic agents have been used to diminish hemodynamic responses to tracheal intubation. [15][16][17] Furthermore, lidocaine has a suppressive effect on the circulatory responses in patients undergoing laryngoscopy and tracheal intubation.…”

Section: Introductionmentioning

confidence: 99%

Fentanyl and fentanyl plus lidocaine on attenuation of haemodynamic stress response to laryngoscopy: a comparative study in controlled hypertensive patients posted for laparoscopic cholecystectomy

2015

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Effects of Esmolol, Lidocaine and Fentanyl on Haemodynamic Responses to Endotracheal Intubation

Cited by 65 publications

References 26 publications

Efeitos de esmolol, lidocaína e fentanil nos intervalos dispersão da onda P, QT, QTc e respostas hemodinâmicas à intubação endotraqueal durante indução com propofol: um estudo comparativo

Efeitos de esmolol, lidocaína e fentanil nos intervalos dispersão da onda P, QT, QTc e respostas hemodinâmicas à intubação endotraqueal durante indução com propofol: um estudo comparativo

A comparative evaluation of dexmedetomidine and fentanyl to attenuate hemodynamic response to laryngoscopy and intubation

Fentanyl and fentanyl plus lidocaine on attenuation of haemodynamic stress response to laryngoscopy: a comparative study in controlled hypertensive patients posted for laparoscopic cholecystectomy

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