Effects of erythropoietin and vitamin E-modified membrane on plasma oxidative stress markers and anemia of hemodialyzed patients

Usberti, M; Gerardi, Gianmario; Bufano, Giuseppe; Tira, Paola; Micheli, Annamaria; Albertini, Alberto; Floridi, Ardesio; Lorenzo, Diego Di; Galli, Francesco

doi:10.1053/ajkd.2002.34919

Cited by 65 publications

(55 citation statements)

References 35 publications

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“…Among them, duplicate records, non-RCTs or quasi-RCTs, review and letter, article not in English, other intervention and concerning other outcome were excluded. After the progressive selection process, 14 eligibility studies 1,8,[13][14][15][16][21][22][23][24][25][26][27][28] including five crossover and nine parallel-arm trials were included in this meta-analysis ( Figure 1). …”

Section: Selection and Identification Of Studiesmentioning

confidence: 99%

Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: a meta-analysis

Huang

et al. 2015

Renal Failure

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Background: This was controversial whether vitamin E-coated dialyzer therapy was beneficial for the complications associated with hemodialysis. Therefore, we performed this systematic review to evaluate the effects of vitamin E-coated dialyzer. Methods: Related trials were searched from multiple electronic databases. We conducted meta-analysis to assess changes in the predefined outcomes using RevMan 5.3 software. Results: Meta-analysis showed vitamin E-coated dialyzer therapy could decrease erythropoietin (EPO) resistance index (SMD, À0.24; 95% CI, À0.47 to À0.01; p ¼ 0.04). However, pooled-analysis showed vitamin E-coated dialyzer therapy could not decrease weekly EPO dose (SMD, À0.11; 95% CI, À0.32 to 0.09; p ¼ 0.28) and intima-media thickness (IMT) of the carotid artery (MD, À0.09; 95% CI, À0.2 to 0.01; p ¼ 0.09), and vitamin E-coated dialyzer therapy did not improve the serum hemoglobin (MD, À0.03; 95% CI, À0.18 to 0.13; p ¼ 0.74), albumin levels (SMD, À0.64; 95% CI, À1.62 to 0.34; p ¼ 0.2), in addition, there was no significant difference in serum cholesterol (SMD, À0.07; 95% CI, À0.45 to 0.31; p ¼ 0.71), triglycerides (MD, À2.77; 95% CI, À32.42 to 26.87; p ¼ 0.85), high density lipoprotein (HDL) (SMD, 0.24; 95% CI, À0.14 to 0.62; p ¼ 0.22) and low density lipoprotein (LDL) (SMD, 0.00; 95% CI, À0.38 to 0.37; p ¼ 0.98) levels. Conclusions: Vitamin E-coated dialyzer may reduce the EPO resistance, but there is no conclusive evidence that vitamin E-coated dialyzer can improve the renal anemia, malnutrition, dyslipidemia and atherosclerosis status in hemodialysis (HD) patients. However, high-quality trials with hard clinical endpoints are required to fully elucidate the clinical value of vitamin E-coated dialyzer therapy.

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Section: Selection and Identification Of Studiesmentioning

confidence: 99%

Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: a meta-analysis

Huang

et al. 2015

Renal Failure

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“…Floridi et al (10) have confirmed and quantified in vitro the antioxidant capacity of vitamin E-bonded polysulfone dialyzers. However, clinical research reports on the effects of vitamin E-bonded dialyzers have hitherto been mostly single-center studies (11,12), with no multicenter prospective studies yet reported.…”

Section: Introductionmentioning

confidence: 99%

Randomized Controlled Open-Label Trial of Vitamin E-Bonded Polysulfone Dialyzer and Erythropoiesis-Stimulating Agent Response

Sanaka¹,

Mochizuki²,

Kinugasa³

et al. 2013

Clinical Journal of the American Society of Nephrology

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the VEESA Study Group Summary Background and objectives A 1-year multicenter prospective randomized controlled study was conducted on the effects of vitamin E-bonded polysulfone dialyzers on erythropoiesis-stimulating agent response in hemodialysis patients.Design, setting, participants, & measurements Major inclusion criteria were use of high-flux polysulfone dialyzers with 50-70 ml/min b 2 -microglobulin clearance over 3 months, transferrin saturation over 20%, same erythropoiesisstimulating agent for over 3 months, and hemoglobin at 10-12 g/dl. Hemodialysis patients were placed in four interventional groups: two hemoglobin ranges (10.0-10.9 or 11.0-11.9 g/dl) and two dialyzers. Patients were randomly assigned by central registration to a vitamin E-bonded polysulfone dialyzers or polysulfone control group. Primary end point was relative erythropoiesis resistance index at baseline between groups at 12 months. Erythropoiesis resistance index was defined as total weekly erythropoiesis-stimulating agent dose divided by hemoglobin.Results There were no statistically significant differences in age or sex. There was no significant difference in relative erythropoiesis resistance index between vitamin E-bonded polysulfone dialyzers and control groups at 12 months (vitamin E-bonded polysulfone dialyzers: 1.1, control: 1.3). The vitamin E-bonded polysulfone dialyzers group showed better relative erythropoiesis resistance index than the control group at 11.0-11.9 g/dl hemoglobin (vitamin E-bonded polysulfone dialyzers: 1.0, control: 1.4 at 12 months, significant difference) but no difference at 10.0-10.9 g/dl hemoglobin. ConclusionsThe overall relative erythropoiesis resistance index showed no difference between the vitamin Ebonded polysulfone dialyzers and control groups, although the change in relative erythropoiesis resistance index differed according to hemoglobin level.

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“…18 Excessive oxidative stress increases eryptosis, which is one of the causes of uremic anemia. 19 Maintenance hemodialysis patients must contact dialysis materials and dialysis fluid for several times a week. These processes result in a large number of ROS 20,21 produced, including in the treatment of anemia.…”

Section: Discussionmentioning

confidence: 99%

L-Carnitine inhibits eryptosis induced by uremic serum and the related mechanisms

Sun

Liu

et al. 2015

Renal Failure

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Objective: To investigate whether L-carnitine (LC) inhibits eryptosis induced by uremic serum and the related mechanism. Methods: One percent erythrocyte suspension was cultured by three kinds of mediums in vitro, which was included in the control group (Group C, phosphate buffered saline [PBS]), the uremic serum group (Group U, 30% uremic serum + 70% PBS) and the LC group (Group L, 30% uremic serum + 70% PBS + 200 umol/L LC), respectively. Erythrocytes were collected at 24 and 48 h, respectively. Phosphatidylserine (PS) was estimated from Annexin-V-binding and reactive oxygen species (ROS) by flow cytometry, glutathione (GSH) was estimated from Enzyme linked immunosorbent assays (ELISA) by Microplate reader. Results: Eryptosis in Group C increased as the incubating time extended (3.43 ± 0.37 at 24 h, 4.21 ± 0.44 at 48 h). Eryptosis increased in Group U compared with Group C (6.5 1 ± 0.71 at 24 h, p50.01; 8.55 ± 0.76 at 48 h, p50.01), while decreased in Group L compared with Group U (5.80 ± 0.69 at 24 h, p50.05; 7.87 ± 0.76 at 48 h, p50.05). Meanwhile, ROS of erythrocytes increased in Group U compared with Group C (33.12 ± 1.61 versus 14.83 ± 2.22 at 24 h, p50.01; 42.06 ± 1.81 versus 20.94 ± 1.78 at 48 h, p50.01), and GSH decreased in Group U compared with Group C (25.66 ± 0.32 versus 31.27 ± 0.38 at 24 h, p50.01; 8.53 ± 0.59 versus 17.29 ± 0.54 at 48 h, p50.01). ROS of erythrocytes decreased in Group L compared with Group C (26.29 ± 1.69 at 24 h, p50.01; 36.21 ± 2.00 at 48 h, p50.01). GSH increased in Group L compared with Group U (27.54 ± 0.60 at 24 h, p50.01; 15.18 ± 0.42 at 48 h, p50.01). Conclusions: LC inhibits eryptosis induced by uremic serum, which possibly relates to oxidative stress in part.

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Effects of erythropoietin and vitamin E-modified membrane on plasma oxidative stress markers and anemia of hemodialyzed patients

Cited by 65 publications

References 35 publications

Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: a meta-analysis

Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: a meta-analysis

Randomized Controlled Open-Label Trial of Vitamin E-Bonded Polysulfone Dialyzer and Erythropoiesis-Stimulating Agent Response

L-Carnitine inhibits eryptosis induced by uremic serum and the related mechanisms

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