Effects of Ergocalciferol Added to Calcium on the Risk of Falls in Elderly High-Risk Women

Prince, Richard

doi:10.1001/archinternmed.2007.31

Cited by 188 publications

(157 citation statements)

References 22 publications

Supporting

Mentioning

154

Contrasting

Unclassified

Order By: Relevance

“…Falls ascertainment used a diary method, previously employed to demonstrate treatment effectiveness of daily oral ergocalciferol over 1 year in a study of women of a similar age to those recruited in the present study. (6) The definition of a fall was explained to subjects at the baseline visit. Participants were instructed to record the nature, timing, and any associated features of each fall shortly after this happened in the falls diary.…”

Section: Fall Assessmentmentioning

confidence: 99%

“…A previous 1-year randomized, population-based, controlled trial demonstrated that 1000 IU of daily oral ergocalciferol treatment reduced the risk of falling over a year by about one-third in Western Australian women with a serum 25 hydroxyvitamin D (25OHD) < 60 nmol/L and a history of falls in the previous year. (6) CLINICAL TRIALS…”

mentioning

confidence: 99%

“…The data in this study of 150,000 IU of cholecalciferol administered every 3 months (daily average intake 1667 IU) can be compared to previous studies that prescribed up to 1000 IU per day of vitamin D (15) and three studies using higher-dose, intermittent vitamin D therapy. (8,10,16) The majority of studies of daily vitamin D replacement have demonstrated beneficial effects on falls with an approximately 20% to 30% reduction in event rates (6,15) and, with calcium, a reduction in fractures of about 26%. (17) .…”

mentioning

confidence: 99%

“…(9) Furthermore, a previous published study demonstrated protection against falls risk (odds ratio 0.61) with a serum 25OHD level of 60 AE 14 nmol/L. (6) Fifth, our study used a diary method to collect falls events that may have missed or misclassified some falls compared to more intensive methods. This is, however, unlikely because the event rates reported by more intensive ascertainment of falls were no different from that of the present study.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Effects of three-monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility, and muscle strength in older postmenopausal women: A randomized controlled trial

Glendenning

Zhu

Inderjeeth

et al. 2012

Journal of Bone and Mineral Research

126

111

View full text Add to dashboard Cite

Daily vitamin D in addition to calcium supplementation reduces falls and fractures in older women. However, poor adherence to therapy is a common clinical problem. To examine the effects of supervised oral 3-monthly vitamin D therapy on falls, muscle strength, and mobility, we conducted a 9-month randomized, double-blind, placebo-controlled trial in 686 community-dwelling ambulant women aged over 70 years. Participants received either oral cholecalciferol 150,000 IU every 3 months (n ¼ 353) or an identical placebo (n ¼ 333). All participants were advised to increase dietary calcium intake. Falls data were collected 3-monthly. At baseline, 3, 6, and 9 months, muscle strength was measured by a handheld dynamometer and mobility by the Timed Up and Go (TUG) test. Serum 25 hydroxyvitamin D (25OHD) was measured in a subgroup of 40 subjects. Mean age at baseline was 76.7 AE 4.1 years. The average serum 25OHD value at baseline was 65.8 AE 22.7 nmol/L. By 3, 6, and 9 months after supplementation, 25OHD levels of the vitamin D group were approximately 15 nmol/L higher than the placebo group. Calcium intake did not change significantly between baseline (864 AE 412 mg/day) and 9 months (855 AE 357 mg/day). Faller rates in the two groups did not differ: vitamin D group, 102 of 353 (29%); placebo group, 89 of 333 (27%). At 9 months, compared to placebo or baseline, muscle strength, and TUG were not altered by vitamin D. In conclusion, oral cholecalciferol 150,000 IU therapy administered 3-monthly had neither beneficial nor adverse effects on falls or physical function. These data together with previous findings confirm that intermittent large doses of vitamin D are ineffective or have a deleterious effect on falls. Thus despite adherence issues with daily vitamin D replacement, an intermittent, high-dose vitamin D regimen cannot be supported as a strategy to reduce falls and fractures. ß

show abstract

Section: Fall Assessmentmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of three-monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility, and muscle strength in older postmenopausal women: A randomized controlled trial

Glendenning

Zhu

Inderjeeth

et al. 2012

Journal of Bone and Mineral Research

126

111

View full text Add to dashboard Cite

show abstract

“…20 All women were given calcium 1000 mg per day and were randomized to receive either ergocalciferol 1000 IU per day or placebo. Women in the study group had fewer falls after 12 months, but this was not a significant difference (53% versus 62.9%; odds ratio, 0.66; 95% CI, 0.41-1.06).…”

Section: Vitamin D and Falls Among The Elderlymentioning

confidence: 99%