Effects of equine metabolic syndrome on inflammation and acute-phase markers in horses

Żak, Agnieszka; Siwińska, Natalia; Elzinga, Sarah; Barker, Virginia D.; Stefaniak, Tadeusz; Schanbacher, B.J.; Place, Ned J.; Niedźwiedź, Artur; Adams, Amanda A.

doi:10.1016/j.domaniend.2020.106448

Cited by 25 publications

(24 citation statements)

References 65 publications

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“…In this study, we found differences between healthy vs. total colic horses at admission time. Our results are in line with previous studies that reported differences between sick vs. healthy bovine [16,18,20,25], horses [14,15,19,24,26] and foals [13] affected by different diseases.…”

Section: Discussionsupporting

confidence: 93%

“…Procalcitonin (PCT) has been studied over the last few years as a biomarker of inflammation and/or infection, both in human [22] and in large animal species [13][14][15][16][17][18][19][20][21][23][24][25][26]. The aims of this study were to evaluate the potential differences in plasma PCT concentrations between healthy vs. SIRS-negative vs. SIRS-positive horses in order to understand if PCT can be a useful biomarker to distinguish between these conditions and drive clini-cal decisions of equine veterinarians and SIRS score in order to verify if this biomarker could be useful for the evaluation of SIRS severity.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses

Nocera¹,

Bonelli²,

Vitale³

et al. 2021

Animals

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Colic horses show systemic inflammatory response syndrome (SIRS) clinical signs. Procalcitonin (PCT) showed increased circulating levels in sick horses. This study compares plasma PCT concentrations in healthy vs. SIRS negative/positive colic horses over time, and evaluates PCT and SIRS score potential correlation, to verify the usefulness of PCT for the evaluation of SIRS severity. Ninety-one horses were included; 43/91 were healthy, on basis of physical examination, blood work and SIRS score (score = 0), while 48/91 were sick colic horses, classified as SIRS-negative (score < 2) and positive (score ≥ 2). Moreover, a 0–6 point-scale SIRS score was calculated (assessing mucous membrane color and blood lactate concentration). PCT was evaluated at admission, and at 24, 48, 72 and 96 h, using a commercial kit for equine species. We verified by the ANOVA test PCT differences between healthy vs. colic horses, healthy vs. SIRS-negative or SIRS-positive colic horses, at all sampling times, and the correlation between the SIRS score at admission with the SIRS score. Statistically significant differences were detected between healthy vs. all colic horses and between healthy vs. SIRS-positive or negative horses at all sampling times. No correlation was observed between the SIRS score at admission and PCT values. PCT was statistically higher in colic horses compared to the healthy ones, suggesting a role as a biomarker for colic.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses

Nocera¹,

Bonelli²,

Vitale³

et al. 2021

Animals

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“…Insulin concentration was measured with a commercially available human insulin radioimmunoassay (RIA) (EMD Millipore Corp, Billerica, MA, USA) that was validated for use in equine serum samples, as previously described [15]. ACTH was measured with a previously validated chemiluminescent assay (Immulite, Diagnostics Product Corporation; Los Angeles, CA, USA) [15].…”

Section: Hormonesmentioning

confidence: 99%

Effects of Advanced Age, Pituitary Pars Intermedia Dysfunction and Insulin Dysregulation on Serum Antioxidant Markers in Horses

et al. 2020

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The study aims to assess the impact of age, pituitary pars intermedia dysfunction (PPID) and insulin dysregulation (ID) in horses on selected oxidative stress markers. The study includes 32 horses, divided into three groups: “young” adult group (aged 8–16 years old) “geriatric” group (aged 18–24 years old) and the “PPID” group (aged 15–31 years old). The PPID group was further divided into two subgroups: PPID ID+ and PPID ID− based on presence or absence of ID. We measured serum antioxidant stress markers in all horses: total oxidant status (TOS), total antioxidant capacity (TAC), ceruloplasmin (CER), lipofuscin (LPS), malondialdehyde (MDA) and thiols concentrations (containing sulfhydryl group -SH) as well as enzymatic systems: total superoxide dismutase (SOD), cytoplasmic SOD (CuZnSOD), mitochondrial SOD activity (MnSOD). Total serum thiols were significantly lower in the geriatric group and in the PPID group compared to the young group. The MnSOD concentration was higher in the PPID ID+ group compared to the PPID ID−. LPS and MDA concentrations were lower in the PPID ID+ group compared to the PPID ID− group. In the selected study groups of horses, older age, the presence of PPID and ID in the case of PPID had no effect on the studied oxidative stress markers.

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“…The individualized nutrition framework in humans considers information about an individual's lifestyle, dietary habits, genetics, functional genomic landscape, metabolome, and microbiome as critical data to understand mechanisms and treatments behind a myriad of diseases, with promising results for ameliorating symptoms associated with metabolic disease [63,64]. Given the high rates of metabolic disorders in domestic animals, including companion, work, and endurance horses [65][66][67], and the economic losses linked to these health issues, an individualized nutrition approach for metabolic and other diseases that considers individualized microbiome pro les and speci c metabolic responses to particular diets may prove to be promising.…”

Section: Individualized Responses To Alfalfa Ligni Cationmentioning

confidence: 99%

The Horse Gut Microbiome Responds in a Highly Individualized Manner to Forage Lignification

Gómez

Sharma

Grev

et al. 2021

Journal of Equine Veterinary Science

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Effects of equine metabolic syndrome on inflammation and acute-phase markers in horses

Cited by 25 publications

References 65 publications

Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses

Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses

Effects of Advanced Age, Pituitary Pars Intermedia Dysfunction and Insulin Dysregulation on Serum Antioxidant Markers in Horses

The Horse Gut Microbiome Responds in a Highly Individualized Manner to Forage Lignification

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