Effects of Epinephrine and Nor-Epinephrine on Blood Flow Through Normal and Denervated Limbs of Dogs

Imig, Charles J.; Randall, Barbara F.; Hines, H. M.

doi:10.1152/ajplegacy.1952.169.1.22

Cited by 8 publications

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“…It would therefore appear that for brief rapid changes in blood flow the ratio of blood pressure to muscle flow is not a true measure of the vascular resistance. Imig et al (1952) state that they obtained an increase in blood flow with an intravenous infusion of noradrenaline (02-0.4 4,g/kg/min) which did not cause significant changes in blood pressure; we have not been able to confirm these results. 113 8 SUMMARY 1.…”

Section: Intravenous Infusions Salinementioning

confidence: 69%

“…Some workers found it to have a purely vasoconstrictor effect (Goldenberg, Pines, Baldwin, Greene & Roh, 1948, man;Swan, 1949, man;de Largy, Greenfield, McCorry & Whelan, 1950, man;Burn & Hutcheon, 1949, cat). Others observed that it had a purely vasodilator action (Meier, Gross & Eichenberger, 1949, cat;McDowall, 1950, cat;Imig, Randall & Hines, 1952, small doses (0-2-0-4jug/kg/min), unanaesthetized dog). A transient dilatation followed by constriction has been observed by Wakim & Essex (1952, dog), and Imig et al (1952, 2p,g/kg body weight, unanaesthetized dog).…”

mentioning

confidence: 99%

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Responses of muscle blood vessels to intra‐arterially and intravenously administered noradrenaline

Cobbold¹,

Vass²

1953

The Journal of Physiology

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(0-2-0-4jug/kg/min), unanaesthetized dog). A transient dilatation followed by constriction has been observed by Wakim & Essex (1952, dog), and Imig et al. (1952, 2p,g/kg body weight, unanaesthetized dog).We have compared the action ofintra-arterial and intravenous noradrenaline on the blood vessels of the skeletal muscle of the anaesthetized cat. The responses differed, but an adequate explanation capable of experimental proof has been obtained. METHODBlood flow in response to noradrenaline was studied in the hind-leg (thigh) muscles of cats. Noradrenaline was administered by intravenous injection into a fore-limb vein via a polythene cannula and by intravenous infusion from a constant speed apparatus by the same route. Intraarterial injections and infusions were given into the femoral artery; for this purpose a portion of a no. 16 hypodermic needle was sealed to a length of polythene tubing and after insertion into the artery left in situ. For intravenous injection the doses used ranged from 1 to 5 tg/kg and for intravenous infusion the concentration was adjusted to give a rate of 1-5 l.g/kg/min. To obtain a comparable effect with intra-arterial injections and infusions one-tenth of the intravenous strengths was used.The animals were anaesthetized with continuous ether or intravenous chloralose (70 mg/kg), or intraperitoneal pentobarbitone sodium (50 mg/kg), or were spinalized and the brain pithed

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Section: Intravenous Infusions Salinementioning

confidence: 69%

mentioning

confidence: 99%