Effects of Epilepsy on Language Functions: Scoping Review and Data Mining Findings

Dutta, Manaswita; Murray, Laura L.; Miller, Wendy R.; Groves, Doyle

doi:10.1044/2017_ajslp-16-0195

Cited by 18 publications

(17 citation statements)

References 121 publications

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“…These effects might manifest as poorer coordination of attention and reduced allocation of attention to language and memory processes, leading to weaker activation of regions performing integration within semantic, syntactic, and memory subsystems and between them. Therefore, language and memory deficits observed in TLE (Zhao et al, 2014;Jaimes-Bautista et al, 2015;Tramoni-Negre et al, 2017;Dutta et al, 2018) could be explained by the weaker cross-network interactions and dynamics due to poorer involvement of regions that act as an interface between multiple functional systems (Herbet and Duffau, 2020). The reduced activation of these interface regions might be explained by the weaker activation of attention-control networks in TLE patients.…”

Section: Discussionmentioning

confidence: 99%

“…Studies on temporal lobe epilepsy (TLE), the most common form of epilepsy, cite problems with episodic memory and naming or verbal fluency among the most frequent concomitant cognitive deficits (Bell et al, 2011;Bartha-Doering and Trinka, 2014;Zhao et al, 2014;Jaimes-Bautista et al, 2015;Tramoni-Negre et al, 2017;Dutta et al, 2018). The additional risk of the cognitive deficit is imposed by surgery that almost 30% of TLE patients need due to drug-resistant seizures (Sherman et al, 2011;Borger et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Banjac

Roger

Cousin

et al. 2022

Front. Hum. Neurosci.

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Preoperative mapping of language and declarative memory functions in temporal lobe epilepsy (TLE) patients is essential since they frequently encounter deterioration of these functions and show variable degrees of cerebral reorganization. Due to growing evidence on language and declarative memory interdependence at a neural and neuropsychological level, we propose the GE2REC protocol for interactive language-and-memory network (LMN) mapping. GE2REC consists of three inter-related tasks, sentence generation with implicit encoding (GE) and two recollection (2REC) memory tasks: recognition and recall. This protocol has previously been validated in healthy participants, and in this study, we showed that it also maps the LMN in the left TLE (N = 18). Compared to healthy controls (N = 19), left TLE (LTLE) showed widespread inter- and intra-hemispheric reorganization of the LMN through reduced activity of regions engaged in the integration and the coordination of this meta-network. We also illustrated how this protocol could be implemented in clinical practice individually by presenting two case studies of LTLE patients who underwent efficient surgery and became seizure-free but showed different cognitive outcomes. This protocol can be advantageous for clinical practice because it (a) is short and easy to perform; (b) allows brain mapping of essential cognitive functions, even at an individual level; (c) engages language-and-memory interaction allowing to evaluate the integrative processes within the LMN; (d) provides a more comprehensive assessment by including both verbal and visual modalities, as well as various language and memory processes. Based on the available postsurgical data, we presented preliminary results obtained with this protocol in LTLE patients that could potentially inform the clinical practice. This implies the necessity to further validate the potential of GE2REC for neurosurgical planning, along with two directions, guiding resection and describing LMN neuroplasticity at an individual level.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Banjac

Roger

Cousin

et al. 2022

Front. Hum. Neurosci.

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“…In this report we extend this line of research by presenting the results of a phonetic analysis comparing speech samples from people with a confirmed diagnosis of epilepsy to those with a confirmed diagnosis of NES. A recent scoping review provided by Dutta, Murray, Miller, and Grovesc () looked expressly at language abilities; it seems that there is little if anything known about the possible influence of epilepsy on speech (and concomitantly, about the influence of NES on speech). Better diagnostic methods are urgently needed to reduce misdiagnoses and promote a more efficient use of investigations (Malmgren et al, ).…”

Section: Introductionmentioning

confidence: 99%

On the potential of phonetic analysis to distinguish between people with epilepsy and non‐epileptic seizures

Walker

Moon

et al. 2019

Int J App Linguistics

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A body of research has shown that there are linguistic differences in the way people with epilepsy talk about their seizures when compared to those with non‐epileptic seizures. We extend this line of research by presenting the results of a phonetic analysis comparing speech samples from people with a confirmed diagnosis of epilepsy (7 patients), to those with a confirmed diagnosis of non‐epileptic seizures (8 patients). Variables considered include features of pitch, intensity, duration and pausing in their responses to questions from a neurologist during medical history‐taking. We find only limited evidence of differences between the two diagnostic groups (epilepsy vs. non‐epileptic seizures). We discuss possible reasons for this lack of evidence.

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“…Traditionally, language impairment is well recognized in drTLE for verbal fluency ( 76 ) and naming abilities ( 77 ), whereas other important language expressive functions, like spontaneous speech and discourse abilities, are much less addressed by the literature ( 78 ). Although basic language functions are generally considered unaffected in patients with TLE, the narrative discourse seems to be affected ( 79 ), particularly concerning discourse and high-level language abilities ( 80 ), probably associated with low WM capacity ( 81 ). Patients with early-onset TLE show mild discourse production impairments not associated with other language measures, but correlating with WM ( 82 ).…”

Section: Discussionmentioning

confidence: 99%

Working Memory and Language Contribution to Verbal Learning and Memory in Drug-Resistant Unilateral Focal Temporal Lobe Epilepsy

2021

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We aimed to investigate the working memory (WM) and language separate contributions to verbal learning and memory in patients with unilateral drug-resistant temporal lobe epilepsy (drTLE); additionally, we explored the mediating role of WM on the relationship between the number of antiepileptic drugs (AEDs) and short-term verbal memory. We retrospectively enrolled 70 patients with left (LTLE; n = 44) and right (RTLE; n = 26) drTLE. About 40 similar (age and education) healthy controls were used to determine impairments of groups at WM, language (naming and verbal fluency), and verbal learning and memory (five trials list-learning, story memory—immediate recall). To disentangle the effect of learning from the short-term memory, we separately analyzed performances at the first trial, last trial, and delayed-recall list-learning measures, in addition to the total learning capacity (the sum of the five trials). Correlation and regression analyses were used to assess the contribution of potential predictors while controlling for main clinical and demographic variables, and ascertain the mediating role of WM. All patients were impaired at WM and story memory, whereas only LTLE showed language and verbal learning deficits. In RTLE, language was the unique predictor for the most verbal learning performances, whereas WM predicted the results at story memory. In LTLE, WM was the sole predictor for short-term verbal learning (list-learning capacity; trial 1) and mediated the interaction between AED number and the performance at these measures, whereas language predicted the delayed-recall. Finally, WM confounded the performance at short-term memory in both groups, although at different measures. WM is impaired in drTLE and contributes to verbal memory and learning deficits in addition to language, mediating the relationship between AED number and short-term verbal memory in LTLE. Clinicians should consider this overlap when interpreting poor performance at verbal learning and memory in drTLE.

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Effects of Epilepsy on Language Functions: Scoping Review and Data Mining Findings

Cited by 18 publications

References 121 publications

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

On the potential of phonetic analysis to distinguish between people with epilepsy and non‐epileptic seizures

Working Memory and Language Contribution to Verbal Learning and Memory in Drug-Resistant Unilateral Focal Temporal Lobe Epilepsy

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