Effects of epigallocatechin-3-gallate on pentylenetetrazole-induced kindling, cognitive impairment and oxidative stress in rats

Xie, Ting; Wang, Weiping; Mao, Zhuo-feng; Qu, Zhenzhen; Luan, Shao-qun; Jia, Lijing; Kan, Min-chen

doi:10.1016/j.neulet.2012.04.001

Cited by 82 publications

(52 citation statements)

References 18 publications

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“…In summary, cognitive impairment was evidenced in several tests such as the Morris water maze (MWM) [57,58], the radial arm water maze [54], and passive avoidance [59]. Increased anxiety was observed in the elevated plus maze test, openfield arena test, cat-odor exposure test, and resident intruder test [54,55,60].…”

Section: Discussionmentioning

confidence: 99%

Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures

Russo

Chimirri

Aiello

et al. 2013

Epilepsy & Behavior

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Section: Discussionmentioning

confidence: 99%

Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures

Russo

Chimirri

Aiello

et al. 2013

Epilepsy & Behavior

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“…Moreover, this epicatechin effects delay both myoclonic jerks and generalized tonic clonic seizures. The results of the research by Xie et al demonstrated anticonvulsant properties of EGCG [16]. …”

Section: Introductionmentioning

confidence: 99%

The Neuroprotective Effect ofCornus mason Brain Tissue of Wistar Rats

Francik

Kryczyk

Krośniak

et al. 2014

The Scientific World Journal

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Cornelian cherry (Cornus mas) is a valuable source of phenolic antioxidants. Flavonoid derivatives as nonenzymatic antioxidants are important in the pathophysiology of many diseases including neurological disorders (e.g., Alzheimer's disease) or heart disease. In this study, we examined the effect of an addition of freeze-dried fruit of cornelian cherry on three types of diets: control diet, fructose diet, and diet enriched in fats (high-fat diet). This effect was studied by determining the following antioxidant parameters in both brain tissue and plasma in rats: catalase, ferric reducing ability of plasma, paraoxonase, protein carbonyl groups, and free thiol groups. Results indicate that both fructose diet and high-fat diet affect the antioxidant capacity of the organism. Furthermore, an addition of cornelian cherry resulted in increased activity of catalase in brain tissue, while in plasma it caused the opposite effect. In turn, with regard to paraoxonase activity in both brain tissue and plasma, it had a stimulating effect. Adding cornelian cherry to the tested diets increased the activity of PON in both tested tissues. Moreover, protective effect of fruits of this plant was observed in the process of oxidation of proteins by decreasing levels of protein carbonyl groups and thiol groups in brain tissue as well as in plasma.

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“…PTZ decreases GABA system function and increases the activity of the glutamate neurotransmission system (47). One of the suggested mechanisms for the neurotoxic effects of PTZ is the ROSinduced oxidative damage in the CNS (48,49).…”

Section: Discussionmentioning

confidence: 99%

Effects of melatonin and theanine administration on pentylenetetrazole-inducedseizures and brain tissue oxidative damage in ovariectomized rats

Choopankareh¹,

Vafaee²,

Shafei³

et al. 2015

Turk J Med Sci

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Background/aim: The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. Materials and methods:The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVX-PTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Mel/Thea-PTZ. Groups 1-4 received saline, while groups 5 and 6 received a combination of Mel/Thea for 6 weeks. All animals except for those in groups 1 and 2 received a single injection of PTZ. Results:The OVX-PTZ group had higher generalized tonic-clonic seizure (GTCS) latency compared to the sham-PTZ group. Administration of Mel/Thea increased minimal clonic seizure and GTCS latencies in both the sham-Mel/Thea-PTZ and OVX-Mel/Thea-PTZ groups compared to the controls. Additionally, PTZ exposure increased malondialdehyde levels and reduced thiol concentrations in brain tissues of both the sham-PTZ and OVX-PTZ groups. Mel/Thea pretreatment resulted in MDA reduction and thiol increase in brain tissues. Conclusion:The results of this study demonstrated the antioxidant and anticonvulsant activities of Mel/Thea despite the presence or absence of ovarian hormones.

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Effects of epigallocatechin-3-gallate on pentylenetetrazole-induced kindling, cognitive impairment and oxidative stress in rats

Cited by 82 publications

References 18 publications

Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures

Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures

The Neuroprotective Effect ofCornus mason Brain Tissue of Wistar Rats

Effects of melatonin and theanine administration on pentylenetetrazole-inducedseizures and brain tissue oxidative damage in ovariectomized rats

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