Effects of (−)-epicatechin on a diet-induced rat model of cardiometabolic risk factors

Gutiérrez-Salmeán, Gabriel; Ortiz-Vilchis, Pilar; Vacaseydel, Claudia Maria; Garduño‐Siciliano, Leticia; Chamorro-Cevallos, Germán; Meaney, Eduardo; Villafaña, Santiago; Villarreal, Francisco; Ceballos, Guillermo; Ramírez-Sánchez, Israel

doi:10.1016/j.ejphar.2014.01.053

Cited by 75 publications

(72 citation statements)

References 33 publications

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“…Due to anti-inflammatory action, flavonoids could protect the integrity of the intestinal barrier [192,195,196]. Flavanol epicatechin and flavonol quercetin suppressed systemic inflammation in rodent models of overfeeding (high fructose and high fat diets) [197][198][199]. Plant extracts rich in anthocyanins and pure anthocyanins could protect Caco-2 cell monolayers from permeabilization due to inflammation [200,201], whereas O-glucosides of delphinidin and cyanidin were more potent than the O-glucosides of petunidin, peonidin and malvidin [200].…”

Section: Effects Of Flavonoids On Gut Microbiotamentioning

confidence: 99%

Flavonoids as Anticancer Agents

et al. 2020

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Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.

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Section: Effects Of Flavonoids On Gut Microbiotamentioning

confidence: 99%

Flavonoids as Anticancer Agents

et al. 2020

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“…(-)-Epicatechin (EPI) is the most abundant polyphenol in cacao, representing nearly 35% of the total phenolic content [18]. Previous reports from our study group have shown that EPI exhibits the same effects than those observed with cacao intake, including decreases in hyperglycemia, hypertrigliceridemia and weight-gain within a high-fat diet-induced murine model of cardiometabolic risk factors [19] through the modulation of mitochondrial structure and metabolism.…”

Section: Introductionmentioning

confidence: 78%

“…Although it has been suggested that flavonoids inhibit intestinal lipid and carbohydrate absorption, [37] we have previously demonstrated that these are not the predominant mechanisms by which EPI exerts its beneficial effects. Instead, we have reported that EPI enhances mitochondrial function and structure which, in turn, promotes oxidative metabolism that further attenuates both weight gain and lipid and glucose disturbances [19]. In addition we have also shown that EPI enhances mitochondrial biogenesis [19].…”

Section: Dietary Interventions Have Been Widely Used For Provoke Obesmentioning

confidence: 85%

Cardiometabolic Alterations in Wistar Rats Induced By an Obesogenic Paigen-Like Diet: Effects of (-) Epicatechin

Sánchez¹

2014

J Diabetes Metab

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Background and objective: The Metabolic Syndrome (MS) is suggested to develop from-among other factorsinadequate diet. To explore its pathophysiology, animal models of diet-induced obesity and its comorbidities are often used, although not all of them produce the same cardiometabolic alterations. Regarding novel therapeutic options, (-)-epicatechin (EPI), the most abundant polyphenol in cacao exerts several beneficial effects on MS features. Therefore, we aimed to test the effects of EPI in the cardiometabolic derangements of rats fed with a diet with added, sugar, saturated fat, added with cholesterol and cholate (Paigen-like diet, PD). Methods: 4 groups of rats were assessed: normal diet (ND); normal diet + EPI (ND+E); Pagen-like diet (PD) and Paigen-like diet + EPI (PD+E, prevention group). EPI was administered by gavage (1 mg/kg daily) for 2 weeks. Body weight, Systolic Blood Pressure (SBP), glycemia, triglyceridemia, total and HDL cholesterol were measured at base, at week 5 and after 2-week period of treatment with EPI (treatment group). Results: PD induced several markers of MS. EPI induced significative decreases in glycemia, triglyceridemia, and SBP. EPI raised HDL level without reaching the basal values. EPI treatment provided by 2 weeks after the MS markers develop (treatment group) induced a considerable weight lost. Conclusion: The PD assayed in this work, effectively induced MS in rodents that are otherwise resistant to dietary modifications. EPI resulted in the attenuation of all cardiometabolic alteration previously induced by diet. These promising results obtained in a murine model with EPI indicate the possibility to begin testing it in human obesity and MS. J ou rna l o f D ia be tes & M e ta bolism

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“…Among these metabolites, hydroxyphenyl-␥-valerolactones represent their most relevant molecular species [26,27]. Interestingly, consumption of flavan-3-ols has been associated with an increase of energy expenditure together with the induction of the BAT thermogenic program, both in rodents and humans [15][16][17][18][19][20][21][22]. Herein, we investigated in vitro for the first time the effect of phenyl-␥-valerolactones and their conjugated forms (sulphated) on the differentiation and function of brown adipocytes.…”

Section: Discussionmentioning

confidence: 99%