Effects of enzymatically modified isoquercitrin in supplementary protein powder on athlete body composition: a randomized, placebo-controlled, double-blind trial

Abstract

Background Enzymatically modified isoquercitrin (EMIQ), a water-soluble quercetin, has been shown to intensify muscle hypertrophy in mice. We investigated the effect of EMIQ in supplementary protein powder on athlete body composition. Methods Forty Japanese males who played American football (age: 19.8 ± 1.4 years; body height: 174.1 ± 6.0 cm; body mass: 75.5 ± 10.7 kg) were assigned to a randomized, placebo-controlled, double-blind trial of parallel group. Participants received either EMIQ in whey protein (EW, n = 19) or contrast whey protein (W, n = 20) 6 days per week over 4 months. Body composition was assessed using dual-energy X-ray absorptiometry. Markers of oxidative stress, derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP), were assessed using a free radical analytical system. Data were analyzed using a univariate and repeated measures general model statistics. Results After 4 months, changes in lower limb fat-free mass and muscle mass were significantly greater in the EW group than in the W group (mean change ±95% CI; W: 324.1 ± 284.3, EW: 950.3 ± 473.2, p = 0.031, W: 255.7 ± 288.6, EW: 930.9 ± 471.5, p = 0.021, respectively). Moreover, the EW group exhibited a significantly higher BAP/d-ROMs ratio, antioxidation index, than the W group after 4 months (mean change ± SD; W: 8.8 ± 1.1, EW: 10.3 ± 2.8; p = 0.028). No significant differences in body mass, lean body mass, fat mass, or lower limb fat mass were observed between the groups. Conclusion Ingestion of EMIQ in supplementary protein powder for 4 months exerts antioxidant effects and increases muscle mass among American football players. Trial registration University Hospital Medical Information Network Clinical Trial Registry, UMIN000036036. Retrospectively registered in 2019.

Neuropharmacological Effects of Quercetin: A Literature-Based Review

“…Enzymatically modified isoquercitrin (EMIQ) has an increased bioavailability and is prepared using a natural enzymatic process that attaches polysaccharides to convert QUR, which has poor bioavailability, into a water-soluble form (Alpha-Glycosyl Isoquercitrin) (Omi et al, 2019). This method has the advantage of high absorption and superior bioavailability.…”

“…This method has the advantage of high absorption and superior bioavailability. According to pharmacokinetic data, the absorption of Isoquercetin is up to 40 times higher (Cmax) than that of QUR and reaches maximum levels in the bloodstream in just 15 min (Omi et al, 2019). Therefore, Isoquercitrine is much more bioactive than QUR and has a broader spectrum of therapeutic activity.…”

Correction to: Effects of enzymatically modified isoquercitrin in supplementary protein powder on athlete body composition: a randomized, placebo-controlled, doubleblind trial

“…The original article [1] contained a typesetting error in Table 3 which was mistakenly introduced by the production team handling this article; this error has now been corrected.…”

Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

“…EOD-1PM may also enhance these reductase activities and improve antioxidant potential. In most cases, studies in healthy subjects using food ingredients that have antioxidant effects show significant differences in the BAP/d-ROMs ratio [ 39 , 40 ]. Ingredients that change BAP alone are extremely rare.…”