Effects of Environmental Enrichment on Nicotine Addiction

Stairs, Dustin J.; Kangiser, Megan M.; Hickle, Tyson; Bockman, Charles S.

doi:10.1016/b978-0-12-800213-1.00023-7

Neuropathology of Drug Addictions and Substance Misuse 2016

DOI: 10.1016/b978-0-12-800213-1.00023-7

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Effects of Environmental Enrichment on Nicotine Addiction

Dustin J. Stairs

Megan M. Kangiser

Tyson Hickle

et al.

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2017

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“…Following exposure to nicotine during periadolescence when animals were challenged with either d-amphetamine or nicotine in adulthood, EC rats did not exhibit locomotor sensitization to nicotine and did not show cross-sensitization to a low dose of d-amphetamine, while IC rats did show nicotine sensitization and cross-sensitization to a low dose of d-amphetamine. This suggests that environmental enrichment can serve as a protectant against the effects of adolescent nicotine exposure, which may cause sensitization to the rewarding effects of future stimulant use (Stairs, Kangiser, Hickle, & Bockman, 2016). …”

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Effects of environmental enrichment on d-amphetamine self-administration following nicotine exposure.

Stairs

Ewin

Kangiser

et al. 2017

Experimental and Clinical Psychopharmacology

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Adolescent nicotine exposure has been shown to lead to further psychostimulant use in adulthood. Previous preclinical research in rats has shown that environmental enrichment may protect against drug abuse vulnerability. The current study was designed to examine whether environmental enrichment can block the ability of adolescent nicotine exposure to increase d-amphetamine self-administration in adulthood. Male Sprague Dawley rats were raised in either enriched conditions (EC) or isolated conditions (IC) and then injected with saline or nicotine (0.4 mg/kg, s.c.) for seven days during adolescence. In adulthood rats were allowed to self-administer d-amphetamine under fixed ratio (0, 0.006, 0.01, 0.02, 0.06, and 0.1 mg/kg/infusion) and progressive ratio (0, 0.006, 0.06, and 0.1 mg/kg/infusion) schedule of reinforcement. Nicotine-treated IC rats self-administered more d-amphetamine at 0.006, 0.01 and 0.02 mg/kg/infusion doses compared to their saline-treated IC counterparts regardless of the schedule maintaining behavior. This effect of nicotine was reversed in EC rats on a fixed ratio schedule. These findings indicate that environmental enrichment can limit the ability of adolescent nicotine exposure to increase vulnerability to other psychostimulant drugs, such as d-amphetamine.

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confidence: 99%

Effects of environmental enrichment on d-amphetamine self-administration following nicotine exposure.

Stairs

Ewin

Kangiser

et al. 2017

Experimental and Clinical Psychopharmacology

Self Cite

View full text Add to dashboard Cite

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Effects of Environmental Enrichment on Nicotine Addiction

Cited by 1 publication

References 38 publications

Effects of environmental enrichment on d-amphetamine self-administration following nicotine exposure.

Effects of environmental enrichment on d-amphetamine self-administration following nicotine exposure.

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