Effects of environmental concentrations of the antiepilectic drug carbamazepine on biomarkers and cAMP-mediated cell signaling in the mussel Mytilus galloprovincialis

Martin-Diaz, Laura; Franzellitti, Silvia; Buratti, Sara; Valbonesi, Paola; Capuzzo, Antonio; Fabbri, Elena

doi:10.1016/j.aquatox.2009.06.015

Cited by 187 publications

(96 citation statements)

References 36 publications

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“…However, in the present study, the CAT activity did not change significantly after the exposure to CBZ. Similarly, Martin-Diaz et al (2009) reported no significant alteration on CAT activity in the mussel Mytilus galloprovincialis exposed to CBZ (10 μg/L, 7 days). On the other hand, Chen et al (2014) observed that the increase in CAT activity after exposure of the clam C. fluminea to CBZ (5 and 50 μg/L, 30 days) was due to the hydrogen peroxide formation resulting from the increase in superoxide anion production and its conversion by SOD.…”

Section: Discussionmentioning

confidence: 93%

“…Recent studies assessing the chronic toxicity of drugs have been showing higher toxicity than the acute tests, revealing that aquatic organisms of different species (e.g. algae, crustaceans, fish) can be impaired even when exposed to environmentally relevant concentrations of drugs (Martin-Diaz et al, 2009;Li et al, 2010;Aguirre-Martínez et al, 2013a;Tsiaka et al, 2013;Chen et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Oetken et al, 2005;Zhang et al, 2012). Moreover, chronic studies performed with environmental concentrations have shown that CBZ can affect multiple oxidative and biochemical pathways in bivalves, with significant deleterious effects (Martin-Diaz et al, 2009;Contardo-Jara et al, 2011;Chen et al, 2014). The impact of CBZ was reported in other species, namely algae (Tsiaka et al, 2013), crustacean (Aguirre-Martínez et al, 2013a) and fish (Gagné et al, 2006a;Li et al, 2009Li et al, , 2010.…”

Section: Introductionmentioning

confidence: 99%

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Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum

Almeida

Freitas

Calisto

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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The impacts of carbamazepine (CBZ) on aquatic organisms are yet not well investigated. The present study aimed to better understand the chronic effects of environmentally relevant concentrations of CBZ. The experiment was performed by exposing the filter feeding clam Ruditapes philippinarum to 0.00, 0.03, 0.30, 3.00 and 9.00 μg/L, during 28 days. To assess the chronic toxicity of the drug a battery of biomarkers related with health status and oxidative stress was applied. In order to quantify CBZ in the clam's tissues and in water samples ELISA was used. The present study showed three types of responses on the clams after a chronic exposure to CBZ. For control condition and the lower concentrations (0.03 and 0.30 μg/L) a "similar" metabolic state was observed and the most efficient antioxidant status leading to the elimination of reactive oxygen species formed during the metabolism of CBZ. The concentration of 3.00 μg/L seemed to be a "threshold" concentration, beyond which the concentration levels of CBZ began to exert a toxic effect, compromising the activity of biotransformation and antioxidant enzymes, with notorious effects at the highest CBZ concentration (9.00 μg/L). CBZ also seemed to alter the energy-related responses, especially the glycogen and electron system responses, revealing a slowdown in metabolism at the higher exposure concentrations (3.00 and 9.00 μg/L). Overall, the present study demonstrated that the higher CBZ concentrations can lead to the impairment of antioxidant enzymes compromising the neutralization of reactive oxygen species, and thus the ability to cope with oxidative stress.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum

Almeida

Freitas

Calisto

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…2009)) have known negative effects on aquatic and marine organisms (e.g., Fong & Molnar, 2008; Metcalfe et al., 2010; Meredith‐Williams et al, 2012; Gaw et al., 2014). Our study and others have assessed the effects of single pharmaceuticals on animal behavior and their potential to alter species interactions (Bossus et al., 2014; Gaworecki & Klaine, 2008; Hazelton et al., 2013; Piggott, Baldwin, Dissanayake, & Sloman, 2007).…”

Section: Discussionmentioning

confidence: 99%

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

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Predators exert considerable top‐down pressure on ecosystems by directly consuming prey or indirectly influencing their foraging behaviors and habitat use. Prey is, therefore, forced to balance predation risk with resource reward. A growing list of anthropogenic stressors such as rising temperatures and ocean acidification has been shown to influence prey risk behaviors and subsequently alter important ecosystem processes. Yet, limited attention has been paid to the effects of chronic pharmaceutical exposure on risk behavior or as an ecological stressor, despite widespread detection and persistence of these contaminants in aquatic environments. In the laboratory, we simulated estuarine conditions of the shore crab, Hemigrapsus oregonensis, and investigated whether chronic exposure (60 days) to field‐detected concentrations (0, 3, and 30 ng/L) of the antidepressant fluoxetine affected diurnal and nocturnal risk behaviors in the presence of a predator, Cancer productus. We found that exposure to fluoxetine influenced both diurnal and nocturnal prey risk behaviors by increasing foraging and locomotor activity in the presence of predators, particularly during the day when these crabs normally stay hidden. Crabs exposed to fluoxetine were also more aggressive, with a higher frequency of agonistic interactions and increased mortality due to conflicts with conspecifics. These results suggest that exposure to field‐detected concentrations of fluoxetine may alter the trade‐off between resource acquisition and predation risk among crabs in estuaries. This fills an important data gap, highlighting how intra‐ and interspecific behaviors are altered by exposure to field concentrations of pharmaceuticals; such data more explicitly identify potential ecological impacts of emerging contaminants on aquatic ecosystems and can aid water quality management.

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“…Toxicity tests have been used worldwide with different objectives, such as to determine environmental health, establish maximum limits for the discharge of chemicals and effl uents, defi ne critical areas, and provide a biological understanding of the chemicals found in the environment and among others goals [1][2][3][4]. Most of the purposes cited above require environmental studies (monitoring and assessment) or the establishment of maximum limits for chemical discharge into the environment.…”

Section: Introductionmentioning

confidence: 99%

Using the Amphipod Hyale Nigra to Assess the Quality of Marine Sediments

Passarelli¹,

César²,

Dms³

2017

Ann Limnol Oceanogr

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Few species are standardized and have been used as test organisms around the world in ecotoxicological assays. In the case of sediment assessment, there are only two amphipod species (Tiburonella viscana and Grandidierella bonnieroides) standardized protocols for toxicity test in South Atlantic region.In order to evaluate the possibility of using the epibenthic marine amphipod Hyale nigra in toxicity tests, a sensitivity test using spiked sediment method was applied, with cadmium chloride as a reference toxicant (CdCl2). Tests with environmental samples were performed to validate the test organisms. The samples were taken from Santos Estuary and Bay in state of Sao Paulo, Brazil. The historical toxicity and contamination are mentioned in the literature. The results obtained in the spiked sediment tests showed little variation in the sensitivity of Hyale nigra amphipod with a mean LC50 value of 5.73 mg.L-1 (1.51 mg.L-1 -8.75 mg.L-1). In the tests with environmental samples, the results obtained were similar to those found in the literature regarding this sampling area. This study demonstrates the potential of Hyale nigra amphipod as a test organism in toxicity tests, once that the specie is sensitive and its results were similar to those reported in the literature on other species of amphipods that are already used in ecotoxicological studies.

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Effects of environmental concentrations of the antiepilectic drug carbamazepine on biomarkers and cAMP-mediated cell signaling in the mussel Mytilus galloprovincialis

Cited by 187 publications

References 36 publications

Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum

Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Using the Amphipod Hyale Nigra to Assess the Quality of Marine Sediments

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