Effects of environmental chemicals on fish thyroid function: Implications for fisheries and aquaculture in Australia

Nugegoda, Dayanthi; Kibria, Golam

doi:10.1016/j.ygcen.2016.02.021

Cited by 38 publications

(22 citation statements)

References 89 publications

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“…The change in the thyroid system in response to a salinity challenge suggests it is involved and/or affected during the acclimation of seabream to changing osmolality conditions. Physiological processes regulated by the thyroid system such as growth or reproduction (Nugegoda and Kibria, 2016), of paramount relevance for the aquaculture, will consequently be modified when seabream culture occurs at different salinities.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the peripheral thyroid system of gilthead seabream acclimated to different ambient salinities

Ruíz-Jarabo

Klaren

Louro

et al. 2017

Comparative Biochemistry and Physiology Part A: Molecular &

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Thyroid hormones are involved in many developmental and physiological processes, including osmoregulation. The regulation of the thyroid system by environmental salinity in the euryhaline gilthead seabream (Sparus aurata) is still poorly characterized. To this end seabreams were exposed to four different environmental salinities (5, 15, 40 and 55ppt) for 14days, and plasma free thyroid hormones (fT3, fT4), outer ring deiodination and Na/K-ATPase activities in gills and kidney, as well as other osmoregulatory and metabolic parameters were measured. Low salinity conditions (5ppt) elicited a significant increase in fT3 (29%) and fT4 (184%) plasma concentrations compared to control animals (acclimated to 40ppt, natural salinity conditions in the Bay of Cádiz, Spain), while the amount of pituitary thyroid stimulating hormone subunit β (tshb) transcript abundance remained unchanged. In addition, plasma fT4 levels were positively correlated to renal and branchial deiodinase type 2 (dio2) mRNA expression. Gill and kidney T4-outer ring deiodination activities correlated positively with dio2 mRNA expression and the highest values were observed in fish acclimated to low salinities (5 and 15ppt). The high salinity (55ppt) exposure caused a significant increase in tshb expression (65%), but deiodinase gene expression (dio1 and dio2) and activity did not change and were similar to controls (40ppt). In conclusion, acclimation to different salinities led to changes in the peripheral regulation of thyroid hormone metabolism in seabream. Therefore, thyroid hormones are involved in the regulation of ion transport and osmoregulatory physiology in this species. The conclusions derived from this study may also allow aquaculturists to modulate thyroid metabolism in seabream by adjusting culture salinity.

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Section: Discussionmentioning

confidence: 99%

Characterization of the peripheral thyroid system of gilthead seabream acclimated to different ambient salinities

Ruíz-Jarabo

Klaren

Louro

et al. 2017

Comparative Biochemistry and Physiology Part A: Molecular &

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“…Thyroid disruption by exposure to environmental toxicants such as metals [e.g., cadmium ( 384 )], pesticides [e.g., organophosphorous pesticides ( 385 )], and pollutants [e.g., polychlorinated biphenyls, PCBs ( 386 )] could result in increased larval mortality and developmental deficiencies ( 387 ) depending on the aquaculture system and species.…”

Section: Relevance Of the Thyroid Axis In Aquaculturementioning

confidence: 99%

The Role of the Thyroid Axis in Fish

2020

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In all vertebrates, the thyroid axis is an endocrine feedback system that affects growth, differentiation, and reproduction, by sensing and translating central and peripheral signals to maintain homeostasis and a proper thyroidal set-point. Fish, the most diverse group of vertebrates, rely on this system for somatic growth, metamorphosis, reproductive events, and the ability to tolerate changing environments. The vast majority of the research on the thyroid axis pertains to mammals, in particular rodents, and although some progress has been made to understand the role of this endocrine axis in non-mammalian vertebrates, including amphibians and teleost fish, major gaps in our knowledge remain regarding other groups, such as elasmobranchs and cyclostomes. In this review, we discuss the roles of the thyroid axis in fish and its contributions to growth and development, metamorphosis, reproduction, osmoregulation, as well as feeding and nutrient metabolism. We also discuss how thyroid hormones have been/can be used in aquaculture, and potential threats to the thyroid system in this regard.

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“…Investigations of Cd thyrotoxicity on different fish species demonstrated altered fish thyroid cascade as a result of both acute and chronic Cd exposure, as reviewed by Nugegoda and Kibria [ 40 ]. In a study conducted by Hontela et al [ 41 ] juvenile rainbow trout ( O. mykiss ) were exposed to 0, 0.4, 0.8 and 2.4 mg Cd/L for 4, 24, 96 h and to 0, 0.4 and 0.8 mg Cd/L for a week through their water.…”

Section: Cadmium Effects On Thyroid Functionmentioning

confidence: 99%

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

Buha

Matović

Antonijević

et al. 2018

IJMS

162

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Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.

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Effects of environmental chemicals on fish thyroid function: Implications for fisheries and aquaculture in Australia

Cited by 38 publications

References 89 publications

Characterization of the peripheral thyroid system of gilthead seabream acclimated to different ambient salinities

Characterization of the peripheral thyroid system of gilthead seabream acclimated to different ambient salinities

The Role of the Thyroid Axis in Fish

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

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