2001
DOI: 10.1111/j.1600-0463.2001.tb05780.x
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Effects of environmental antiandrogens on reproductive development in experimental animals

Abstract: 1Chemicals that act as androgen receptor (AR) agonists and antagonists or inhibit fetal steroidogenesis can induce reproductive malformations in humans and laboratory animals. Several environmental chemicals disrupt development in rats and/or rabbits at fetal concentrations at, or near, exposure levels seen in some segments of the human population. In rats, fetal tissues concentrations of 1 6 2 0 p.p.m. of the DDT metabolite, p,p'-DDE, are correlated with reproductive abnormalities in male offspring. These con… Show more

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Cited by 109 publications
(135 citation statements)
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“…Male rat pups exposed to DES during gestation (at concentrations similar to those measured in first-trimester human fetal tissues) developed hypospadias [50,51]. Hypospadias was also found in male rodents after maternal treatment with vinclozolin (dose-response effect) [52], and similar findings were recorded for prenatal exposure to polychlorinated biphenyls (PCB), phthalates and dioxin [52][53][54].…”
Section: Ii-1 Arguments For An Environmental Contributionsupporting
confidence: 58%
“…Male rat pups exposed to DES during gestation (at concentrations similar to those measured in first-trimester human fetal tissues) developed hypospadias [50,51]. Hypospadias was also found in male rodents after maternal treatment with vinclozolin (dose-response effect) [52], and similar findings were recorded for prenatal exposure to polychlorinated biphenyls (PCB), phthalates and dioxin [52][53][54].…”
Section: Ii-1 Arguments For An Environmental Contributionsupporting
confidence: 58%
“…Despite the certainty that androgen action is essential for the regulation of spermatogenesis in adult mammals, little is known about the mechanisms via which this regulation is exerted and by which smoking and its metabolites could affect these pathways. We can speculate that smoking and tobacco chewing; being estrogenic and antiandrogenic compounds could inhibit androgens from binding to their receptors, eventually leading to lower testosterone levels (Gray et al, 2001). However, binding to the specific receptors is only one of the several, and still unknown, ways a chemical can act as an endocrine disrupter (Tabb and Blumberg, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…The focus of many early studies was on the estrogenic and antiandrogenic actions of various agricultural chemicals such as dichlorodiphenyltrichloroethane (DDT) and its metabolites, methoxychlor, and vinclozlin and industrial compounds such as polychlorinated biphenyls (PCBs), alkylphenol ethoxylates (APEs), and phthalates (4)(5)(6)(7)(8)(9). To date, research has focused on the effects of environmental exposure to these chemicals on reproduction and development in wildlife and/or investigating the underlying mechanisms for some of the observed effects in laboratory and environmentally exposed wildlife species.…”
mentioning
confidence: 99%