Effects of enterally fed epidermal growth factor on the small and large intestine of the suckling rat

Pollack, Paul; Goda, Toshinao; Colony, Pamela C.; Edmond, John; Thornburg, William; Korc, Murray; Koldovský, Otakar

doi:10.1016/0167-0115(87)90021-8

Cited by 84 publications

(33 citation statements)

References 40 publications

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“…Rat pups fed a formula supplemented with pharmacological or physiological doses of EGF for 3 -4 d showed an increased intestinal cell proliferation compared with rats fed the nonsupplemented formula (97,98) . Other studies have investigated the effect of EGF with parenteral administration, which makes it difficult to conclude on the beneficial effect of supplementing formulas with this growth factor.…”

Section: Growth Factorsmentioning

confidence: 99%

Breast-v.formula-feeding: impacts on the digestive tract and immediate and long-term health effects

2010

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The health benefits of breast-feeding have been recognised for a long time. In particular, breast-feeding is associated with lower incidence of necrotising enterocolitis and diarrhoea during the early period of life and with lower incidence of inflammatory bowel diseases, type 2 diabetes and obesity later in life. The higher nutritional and protective degree of human milk is related to its nutritional composition that changes over the lactation period and to the biological activities of specific components while lower growth rate of breast-fed infants may be attributed to their self-regulation of milk intake at a lower level than formula-fed infants. Many results now suggest that the developmental changes in intestinal and pancreatic function that occur postnatally are modulated by the diet. Indeed, formula-feeding induces intestinal hypertrophy and accelerates maturation of hydrolysis capacities; it increases intestinal permeability and bacterial translocation, but does not induce evident differences in microbiota composition. Whether these changes would be beneficial for enhancing absorptive capacities and for educating the gut-associated immune system remains to be further studied. Moreover, it is evident that formula-feeding increases basal blood glucose and decreases plasma ketone body concentrations, while discrepancies on postprandial glycaemia, insulin and incretin responses in both human studies and experimental studies are inconclusive. Manipulating the composition of formula, by reducing protein content, adding prebiotics, growth factors or secretory IgA can modulate intestinal and pancreatic function development, and thereby may reduce the differential responses between breast-fed and formula-fed neonates. However, the developmental responses of the digestive tract to different feeding strategies must be elucidated in terms of sensitivity to developing diseases, taking into account the major role of the intestinal microbiota.

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Section: Growth Factorsmentioning

confidence: 99%

Breast-v.formula-feeding: impacts on the digestive tract and immediate and long-term health effects

2010

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“…The role of EGFR signaling in promoting gut maturation has also been suggested by in vivo studies in which animals were given exogenous EGF (3)(4)(5). However, because EGFR signaling also affects the development of other fetal organs that include the liver and pancreas (1,6,7), it is not clear whether observations on these experimental models represent endogenous effects of EGFR signaling in the gut or results that are secondary to EGFR signaling in other organs.…”

mentioning

confidence: 99%

EGF Regulates Early Embryonic Mouse Gut Development in Chemically Defined Organ Culture

et al. 2000

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“…EGF and TGFa are trophic peptides in saliva, human milk, and intestinal epithelium (21). In vivo studies, in which EGF was given to animals orally or systemically, have generally shown stirnulatory effects of exogenous EGF on the intestine (7,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). Parenteral EGF has consistently been shown to enhance intestinal proliferation and in some cases to alter the expression of brush border enzymes.…”

Section: Discussionmentioning

confidence: 99%

Oral Transforming Growth Factor-α Enhances Jejunal Mucosal Recovery and Electrical Resistance in Piglet Rotavirus Enteritis

et al. 1995

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Effects of enterally fed epidermal growth factor on the small and large intestine of the suckling rat

Cited by 84 publications

References 40 publications

Breast-v.formula-feeding: impacts on the digestive tract and immediate and long-term health effects

Breast-v.formula-feeding: impacts on the digestive tract and immediate and long-term health effects

EGF Regulates Early Embryonic Mouse Gut Development in Chemically Defined Organ Culture

Oral Transforming Growth Factor-α Enhances Jejunal Mucosal Recovery and Electrical Resistance in Piglet Rotavirus Enteritis

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