Effects of enhanced recovery after surgery on postoperative stress state and short-term complications in elderly patients with colorectal cancer

Abstract

Objective: To evaluate the feasibility and necessity of enhanced recovery after surgery in elderly patients with colorectal cancer by observing the inflammatory markers and postoperative complications in patients. Methods: Hospitalized Colorectal cancer patients from the Affiliated Hospital of Jiangsu University during 2021.01-2022.09 were collected and these patients were divided into two groups:ERAS group and non-ERAS group. Postoperative inflammatory markers and complications of patients were collected. Results: 313 patients with colorectal cancer were included, There were 182 patients in the ERAS group and 131 in non-ERAS group. The patients in ERAS group was significantly shorter than the non-ERAS group in terms of postoperative hospitalization days, withdrawal time of urinary catheter, withdrawal time of drainage tube, and recovery of bowel function (P<0.05). In terms of hospitalization expenses, the patients in ERAS group were lower than non-ERAS group, the distinction was statistically significant (P<0.05).However, the level of procalcitonin and TNF-α in ERAS group was significantly lower than non-ERAS group on the post-operative day 1, 3 (P<0.05), the level of IL-6 and IL-10 in ERAS group was significantly lower than non-ERAS group on the 1st ,3rd and 5th day after operation (P<0.05). The levels of CRP and WBC in ERAS group were lower than non-ERAS group on the post-operative day 3, 5 (P<0.05). However,hemoglobin levels did not differ significantly(P>0.05). Albumin levels did not differ significantly between the two groups before surgery (P>0.05), but the level of albumin in ERAS group was higher than non-ERAS group on the post-operative day3,5 (P<0.05). ERAS patients had a lower level of albumin after surgery compared to non-ERAS patients (P<0.05). Conclusion: ERAS leads to a series of perioperative optimization measures, thereby reducing the postoperative stress response of elderly colorectal cancer patients and reducing the occurrence of perioperative complications.