Effects of endothelin ETB receptor agonists and antagonists on the biphasic response in the ileum

Miasiro, Nobuco; Karaki, Hideaki; Matsuda, Yuzuru; Paiva, Antonio C.M.; Rae, Giles A.

doi:10.1016/s0014-2999(99)00062-x

Cited by 15 publications

(9 citation statements)

References 40 publications

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“…These suggest that the contractile effect could be mediated partially by the ET B receptor [40]. In contrast, ET-1 and ET-3 induced relaxation at similar concentrations, indicating that the ET-induced relaxation is mediated by ET B receptors [40,67]. On the other hand, dispersed smooth muscle cells from longitudinal muscle of the guinea-pig small intestine showed a similar contractile response to ET-1, ET-2, and ET-3.…”

Section: Effects Of Endothelins In the Ileummentioning

confidence: 84%

“…Both the relaxation and contraction phases were not affected by tetrodotoxin [66]. This biphasic response may involve activation of different ET receptor subtypes [40] or two ET B receptors with distinct signal transduction mechanism [67]. ET-1 was more potent than ET-3 to cause contraction.…”

Section: Effects Of Endothelins In the Ileummentioning

confidence: 85%

“…In dispersed smooth muscle cells from the guinea-pig small intestine, ET B receptor mediates the contractile effect [36,40,66,67]. It is not clear whether the differences in the effects of ET and the ET receptor subtypes involved in the contraction are due to difference in different experimental conditions (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…relaxation followed by contraction [40,66,67]. Both the relaxation and contraction phases were not affected by tetrodotoxin [66].…”

Section: Effects Of Endothelins In the Ileummentioning

confidence: 96%

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Endothelin Receptors in Gastrointestinal Smooth Muscle

Huang

2005

CPPS

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Endothelins (ETs) are a family of peptides with 21-amino-acid residues. ET-1 was identified as a potent vasoconstrictor produced by vascular endothelial cells. Three distinct isoforms of ET, i.e. ET-1, ET-2 and ET-3, have been found to exist in a variety of tissues. ET was later found to cause contraction as well as relaxation of smooth muscle in many physiologic systems. In the gastrointestinal tract, ET causes contraction and/or relaxation of the esophagus, stomach, ileum and colon. In the hepatobiliary system, ET causes contraction of the portal vein, hepatic stellate cells, gallbladder and common bile duct. In mammalian species, two classes of ET receptors, ET(A) and ET(B), have been cloned. ET(A) receptors have higher affinities for ET-1 and ET-2 than ET-3, while ET(B) receptors have the same affinities for ET-1, ET-2 and ET-3. In the gastrointestinal system, ET causes smooth muscle contraction through interaction with ET(A) receptors, ET(B) receptors or both ET(A) and ET(B) receptors, depending on the tissues and species. In addition to contraction, ET causes smooth muscle relaxation through interaction with ET(A) receptors or ET(B) receptors. At the present time, there are no studies showing that ET causes smooth muscle relaxation through interaction with both ET(A) and ET(B) subtypes. ET induces contraction in most of the non-sphincter muscle except the fundus of the stomach. On the other hand, ET causes relaxation and contraction in the lower esophageal and internal anal sphincters. ET may play an important role in the control of human gastrointestinal motility and portal vein pressure.

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Section: Effects Of Endothelins In the Ileummentioning

confidence: 84%

Section: Effects Of Endothelins In the Ileummentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

“…relaxation followed by contraction [40,66,67]. Both the relaxation and contraction phases were not affected by tetrodotoxin [66].…”

Section: Effects Of Endothelins In the Ileummentioning

confidence: 96%

See 2 more Smart Citations

Endothelin Receptors in Gastrointestinal Smooth Muscle

Huang

2005

CPPS

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“…However, the IC 50 value was much weaker in rats (in the 1 µM range), which rendered this animal model delicate for examining the role of ET B receptor using RES-701-1 as antagonist. The use of RES-701-1 participated in different advances in the understanding of the physiology of the ET B receptor (Conrad et al 1999;Miasiro et al 1999;Gandley et al 2001;Yamaguchi et al 2003;Gardner et al 2005;Cervar-Zivkovic et al 2011;Ji et al 2013). The peptide RES-701-3 showed an antagonist activity similar to that of RES-701-1 , but was not used very much in further studies.…”

Section: Resmentioning

confidence: 99%

Lasso Peptides

Zirah

Rebuffat

2015

SpringerBriefs in Microbiology

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SpringerBriefs in Microbiology present concise summaries of cutting-edge research and practical applications across a wide spectrum of fields. Featuring compact, authored volumes of 50 to 125 pages, the series covers a range of content from professional to academic. Typical topics might include:• A timely report of state-of-the art analytical techniques • A bridge between new research results published in journal articles and a contextual literature review • A snapshot of a hot or emerging topic • An in-depth case study or clinical example • A presentation of core concepts that students must understand in order to make independent contributions • Best practices or protocols to be followed • A series of short case studies SpringerBriefs in Microbiology showcase basic and translational research from a global author community. Briefs allow authors to present their ideas and readers to absorb them with minimal time investment, and will be published as part of Springer's eBook collection, with millions of users worldwide. In addition, Briefs will be available for individual print and electronic purchase.Briefs are characterized by fast, global electronic dissemination, standard publishing contracts, standardized manuscript preparation and formatting guidelines, and expedited production schedules. We aim for publication 8-12 weeks after acceptance.More information about this series at

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