Effects of endothelial nitric oxide synthase on mouse arteriovenous fistula hemodynamics
Shelly Baltazar,
Hannah Northrup,
Joshua Chang
et al.
Abstract:Newly created arteriovenous fistulas (AVFs) often fail to mature for dialysis use due to disturbed blood flow at and near the AVF anastomosis. The disturbed flow inhibits the endothelial nitric oxide synthase (NOS3) pathway, thus decreasing the production of nitric oxide, a vasodilator. Previously, our group reported that NOS3 expression levels affect AVF lumen size in a mouse model. In this study, we performed MRI-based computational fluid dynamics simulations to investigate the hemodynamical parameters (velo… Show more
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