Effects of endomorphin-2 on arterial blood pressure and pain threshold in spontaneously hypertensive rats and modification of these effects by β-funaltrexamine and nor-binaltorphimine

Makulska-Nowak, Helena E.; Gumulka, S. W.; Lipkowski, Andrzej W.; Rawa, M

doi:10.1016/s0024-3205(01)01147-x

Cited by 9 publications

(7 citation statements)

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“…Similarly, endomorphin-1 and endomorphin-2 lowered heart rate and decreased blood pressure in normotensive and spontaneously hypertensive rats (Champion et al, 1997b;Czapla et al, 1998;Kwok and Dun, 1998;Makulska-Nowak et al, 2001), mice (Champion et al, 1998c), and rabbits (Champion et al, 1997a). Interestingly, both peptides produced dose-dependent biphasic changes in systemic arterial pressure in cats (Champion et al, 1998b).…”

Section: A Biological Effects Of Endomorphinsmentioning

confidence: 92%

“…5). The neurochemical substrates mediating mesencephalic morphine analgesia in the rostral ventromedial medulla include, among others, serotonin (5-HT) (Kiefel et al, 1992a,b), GABA (Heinricher et al, 1991;McGowan and Hammond, 1993a,b), the excitatory amino acid transmitters, L-Glu or N-methyl-D-aspartate (Aimone and Gebhart, 1986;Van Praag and Frenk, 1990;Spinella et al, 1996), and neurotensin (Urban and Smith, 1993 Champion et al (1997aChampion et al ( , 1998bChampion et al ( , 1999a; Czapla et al (1998); Kwok and Dun (1998);Makulska-Nowak et al (2001) Decrease of heart rate Rat, mouse i.v. Champion et al (1998cChampion et al ( , 1999b No significant effect on cardiac output induced by i.c.v.…”

Section: A Biological Effects Of Endomorphinsmentioning

confidence: 99%

“…administration in rats was less pronounced than that after i.v. injections (Czapla et THE ENDOMORPHIN SYSTEM AND ITS NEUROPHYSIOLOGICAL ROLE al., 1998; Kwok and Dun, 1998;Makulska-Nowak et al, 2001). This suggests that the peripheral -opioid receptors might play an important role in the endomorphin-2-induced hypotensive effect (Rialas et al, 1998).…”

Section: A Biological Effects Of Endomorphinsmentioning

confidence: 99%

See 2 more Smart Citations

The Endomorphin System and Its Evolving Neurophysiological Role

Fichna

Janecka²,

Costentin³

et al. 2007

Pharmacol Rev

220

171

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Section: A Biological Effects Of Endomorphinsmentioning

confidence: 92%

Section: A Biological Effects Of Endomorphinsmentioning

confidence: 99%

Section: A Biological Effects Of Endomorphinsmentioning

confidence: 99%

See 1 more Smart Citation

The Endomorphin System and Its Evolving Neurophysiological Role

Fichna

Janecka²,

Costentin³

et al. 2007

Pharmacol Rev

220

171

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“…Experimental studies in male rats have confirmed the existence of dependence between systems responsible for pain perception and blood pressure regulation [29]. It has been observed that normotensive and spontaneously hypertensive rats exhibit differences in activities of opioid systems participating in pain control.…”

Section: Discussionmentioning

confidence: 93%

“…It has been observed that normotensive and spontaneously hypertensive rats exhibit differences in activities of opioid systems participating in pain control. Male SHR and WKY rats post-endomorphin-2 administration show considerable differences in analgesic and hypotensive efficacy [29]. Moreover, the differences in pain threshold in SHR versus WKY could have been explained by the hypothesis that activation sympathetic out-flow has a crucial role in essential and secondary hypertension [30]; chronic baroreflex activation therapy has sustained effects to inhibit central sympathetic out-flow and lower blood pressure [31].…”

Section: Discussionmentioning

confidence: 99%

Morphine Analgesia Modification in Normotensive and Hypertensive Female Rats after Repeated Fluoxetine Administration

Kosiorek-Witek

Makulska-Nowak

2015

Basic Clin Pharma Tox

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The purpose of this investigation was to determine through the use of fluoxetine the effect of administering a serotonin reuptake inhibitor over several days on the antinociceptive action of l-morphine type opioid receptor agonist. Investigations were performed on rats of both sexes, both the WKY normotensive strains as well as on the SHR genetically conditioned hypertensive strains. Results showed that the efficacy of morphine analgesia is higher in the SHR strain compared to normotensive rats (WKY). Surprisingly, repeated administration of fluoxetine reduced morphine analgesia, with the weakening of opioid antinociceptive action comparable to the duration of serotonin reuptake inhibitor administration. It was also concluded that the antinociceptive action of morphine in female rats and the alteration of its efficacy as a result of fluoxetine premedication for several days depend on oestrus cycle phase. The highest sensitivity of female rats to morphine was reported in the dioestrus and oestrus phases; much lower values were reported for the metoestrus phase.For decades, young male rats have been the basic group of animals used in research addressing the pharmacological consequences of administering drugs, with research results being extrapolated to the entire population. It is now well-known that males and females may react differently to the administration of drugs. Significant differences have been reported for lmorphine type opioid receptor agonist, which exhibits distinct sexual dimorphism. Sex-dependent differentiation has been reported for sensitivity to analgesic action of such a l-type opioid receptor agonist [1][2][3][4], quickness in developing tolerance and dependence [5], as well as release substance P [6]. Also, a number of investigations have confirmed the influence of morphine on the functioning of the female sexual system. It has been reported that chronic administration of morphine disrupts the oestrus cycle [5]. The effect of sex hormones on the development of sex-dependent differentiation is also shown by the fact that many sex dimorphic features only develop postpuberty. Neither sex-dependent differentiation in heart rate [7] nor pain sensitivity in the case of many pain conditions [8,9] has been reported pre-puberty. It has also been shown that sex steroids modulate large-artery stiffness, thus -in addition to genetic factors -affecting frequency of isolated systolic hyperpressure occurrence [7].Patients treated with morphine often also require use of antidepressants, which include selective serotonin reuptake inhibitors (SSRI). No complete mechanism of SSRI antinociceptive action has yet been offered. Due to the more effective performance analgesic action of fluoxetine compared to the placebo in patients with depression, it is possible that its analgesic efficacy could be related to antidepressant activity [10]. Its place of action could be the same as for the l-type opioid receptor agonists [11], but antinociceptive action could also involve the cholinergic, noradrenergic and G...

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Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice

et al. 2008

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Rationale Recent work in our laboratory documented that the “sipper” method of operant ethanol self-administration produced high ethanol intake and blood ethanol concentrations as well as the typical extinction “burst” in responding under non-reinforced conditions in male C57BL/6 mice. However, the neurochemical basis for reinstatement of responding following extinction has not been examined in mice with this model. Objectives Based on findings that the GABAergic neurosteroid allopregnanolone (ALLO) significantly increased the consummatory phase of ethanol self-administration, the present study determined the effect of ALLO on reinstatement of extinguished ethanol-seeking behavior and compared this effect to reinstatement of responding for sucrose reward. Methods Separate groups of male C57BL/6 mice were trained to lever press for access to a 10% ethanol (10E) or a 5% sucrose (5S) solution. A single response requirement of 16 presses (RR16) on an active lever resulted in 30 min of continuous access to the 10E or 5S solution. After the animals responded on the RR16 schedule for 14 weeks, mice were exposed to 30 min extinction sessions where responding had no scheduled consequence. Once responding stabilized below the pre-extinction baseline, mice received an IP injection of ALLO (0, 3.2, 5.6, 10 or 17 mg/kg) 15 min prior to the extinction session in a within-subjects design. Results ALLO produced a dose-dependent increase in responding under non-reinforced conditions in both the 10E and 5S groups. Additional work documented the ability of a conditioned cue light or a compound cue (light+lever retraction) to reinstate non-reinforced responding on the previously active lever. Conclusions These findings definitively show that conditioned cues and priming with ALLO are potent stimuli for reinstating both ethanol and sucrose seeking behavior in C57BL/6 mice.

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Effects of endomorphin-2 on arterial blood pressure and pain threshold in spontaneously hypertensive rats and modification of these effects by β-funaltrexamine and nor-binaltorphimine

Cited by 9 publications

References 0 publications

The Endomorphin System and Its Evolving Neurophysiological Role

The Endomorphin System and Its Evolving Neurophysiological Role

Morphine Analgesia Modification in Normotensive and Hypertensive Female Rats after Repeated Fluoxetine Administration

Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice

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