Effects of Endogenous Modulators of  -Adrenergic and Cholinergic Receptors on Heart Rate Variability

Tsirkin, V. I.; Nozdrachev, A. D.; Трухин, А. Н.; Сизова, Е. Н.

doi:10.1023/b:dobs.0000017119.41438.a4

Cited by 2 publications

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“…The blood ESBAR and EBMCR have been found both in males and in females during different age periods [13,[15][16][17][18]. The ESBAR and its analogue histidine could enhance β-adrenergic responsiveness of the myocardium, while the EBMCR and lysophosphatidylcholine as a component of the EBMCR [19] could depress M-cholinergic responsiveness of the myocardium, as shown in experiments with an isolated frog heart in studies of the umbilical blood serum and blood from pregnant women [18].…”

Section: Discussionmentioning

confidence: 99%

“…The ESBAR and its analogue histidine could enhance β-adrenergic responsiveness of the myocardium, while the EBMCR and lysophosphatidylcholine as a component of the EBMCR [19] could depress M-cholinergic responsiveness of the myocardium, as shown in experiments with an isolated frog heart in studies of the umbilical blood serum and blood from pregnant women [18]. Therefore, it is suggested that the blood ESBAR and EBMCR in girls are the lowest in winter, causing a decrease in BAEH and an increase in MCEH.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the nature of the ESBAR and EBMCR, it cannot be excluded that the seasonal changes in the blood ESBAR and EBMCR may result from seasonal changes in metabolism. Examination of pregnant women showed a relationship between the HRV and blood levels of the direct EMs of chemoresponsiveness, including the ESBAR, the EBMCR, and the endogenous sensitizer of M-cholinergic receptors (ESMCR), which was recently detected in studies with rat and human myometrium [16,18]. Actually, the HRV was significantly lower in women with high levels of the ESBAR and/or the EBMCR and/or a low level of the ESMCR than in women with opposite levels of the EMs of chemoresponsiveness [18].…”

Section: Discussionmentioning

confidence: 99%

“…Examination of pregnant women showed a relationship between the HRV and blood levels of the direct EMs of chemoresponsiveness, including the ESBAR, the EBMCR, and the endogenous sensitizer of M-cholinergic receptors (ESMCR), which was recently detected in studies with rat and human myometrium [16,18]. Actually, the HRV was significantly lower in women with high levels of the ESBAR and/or the EBMCR and/or a low level of the ESMCR than in women with opposite levels of the EMs of chemoresponsiveness [18]. Although we did not analyze the relationship between the HRV and the blood ESBAR and EBMCR in the 11-to 13-year-old girls, we might expect that the pattern revealed during examination of the blood of pregnant women would be true for the above age period.…”

Section: Discussionmentioning

confidence: 99%

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Seasonal Changes in Heart Rate Variability in 11- to 13-Year-Old Girls

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Tsirkin

et al. 2005

Hum Physiol

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Assessment of the heart rate variability (HRV) in healthy subjects and patients has been widely used in clinical practice and physiological studies [1][2][3]. Yet, interpretation of the nature of HRV, as well as issue of the normal ranges of the standard indices of HRV, is still challenging. This is because of the absence of a single, unified system for processing HRV parameters. At present, there are few data on the relationship between the HRV and gender, age, and chronobiological factors. Analysis of the seasonal changes in HRV in 7-to 9-year-old boys and girls from Izhevsk has shown that the HRV is usually lower in autumn than in spring, thereby indicating that sympathetic tone is higher in autumn than in spring [4]. The objective of this work was to study the seasonal changes in HRV in 11-to 13-year-old girls. METHODSLongitudinal studies were performed with 90 girls aged 11 ( N = 31), 12 ( N = 28), and 13 ( N = 31) to record their HRV parameters at 3-month intervals in winter, spring, summer, and autumn and simultaneously assess their puberty by the development of secondary sexual characteristics and the menstrual cycle.A Valenta computer-integrated medical diagnostic system (St. Petersburg, PO NEO) was used to record the lead II ECG in the supine position with subsequent analysis of 500 cardiac cycles. The system made it possible to automatically process the length of RR intervals and calculate 23 HRV indices (described in detail in [2]), which are consistent with those recommended by the European Society of Cardiology and the North American Society of Pacing and Electrophysiology [1, 2].The following indices were calculated: mathematical expectation ( M , ms); maximum ( RR max ) and minimum ( RR min ) RR intervals (ms); variance (ms 2 ); standard deviation (ms); coefficient of variation (%); mode (Mo, ms); mode amplitude (AMo, %); variation range (VR, ms 2 ); power (ms 2 ) of high frequency (HF) fluctuations (0.5-0.1 Hz); normalized HF power, i.e., relative HF power in proportion to the sum of the HF and low frequency (LF) powers; power (ms 2 ) of LF fluctuations (0.1-0.03 Hz); normalized LF power, i.e., relative LF power in proportion to the sum of the HF and LF powers; power (ms 2 ) of very low frequency (VLF) fluctuations (less than 0.03 Hz); LF/HF, VLF/HF, and (VLF + LF)/HF ratios, or the index of centralization; the coefficient of correlation between HF and respiratory waves (%); the coefficient of monotony [2]; the index of tension (IT) of regulatory systems calculated as IT = AMo/(2VR × Mo); the triangular index, i.e., the ratio between the total number of RR intervals and the number of intervals with the most common length, expressed in technical units [2]; the differential index (DI) of rhythm calculated aswhere i is the number of the current interval, low values of which are indicative of high HRV [2]; and the relative number of successive RR intervals differing by more than 50 ms in proportion to the total number of cardiac intervals ( pRR 50 , %).The results of the study were statistically anal...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Seasonal Changes in Heart Rate Variability in 11- to 13-Year-Old Girls

En²,

Tsirkin

et al. 2005

Hum Physiol

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“…During these years, efforts have been made to clarify the physiological role of ESBAR, in particular, the ability of ESBAR to improve the ef iciency of activation of beta 2 -AR of smooth muscle from pig coronary artery [20,21], the arteries and veins of human umbilical cord [22][23][24], cow renal artery [25][26][27][28], cow trachea [21,[29][30][31], rat stomach [32,33], and also myocardium of frog [34][35][36][37], rats [36][37][38][39][40][41][42] and humans [43][44][45] and human erythrocytes [46]. In addition, our efforts were made to ind analogs of ESBAR [21,27-29, 35-37,39-43,45-60], to study the mechanism of action of ESBAR and its analogs [36,[38][39][40][41][42][43][56][57][58][59][60][61], on the role of ESBAR in the pathogenesis of somatic diseases -coronary heart disease [62]…”

Section: Introductionmentioning

confidence: 99%