Effects of encapsulated porcine islets on glucose and C‐peptide concentrations in diabetic nude mice 6 months after intraperitoneal transplantation

Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes

“…Peak blood glucose concentration occurred within 15 min after glucose administration and did not exceed 200 mg/dL. This comports with peak glucose levels during oral glucose tolerance test in human subjects, and is in agreement with findings that human islets are engaged at lower glucose levels than native or transplanted mouse islets in mouse hosts and that it is the donor islet species that determines the glycemic set point (Abdul-Ghani et al, 2010;Merani et al, 2008;Nishimura et al, 2017;Rodriguez-Diaz et al, 2018;Schneider et al, 2005).…”

The pharmacokinetics of porcine C‐peptide after intraperitoneal injection

“…The kinetics of C‐peptide secreted from the intraperitoneal cavity is unclear. In our previous work, porcine C‐peptide concentrations were approximately 40 times higher in the ascitic fluids than those in the peripheral blood when encapsulated islets were transplanted into the peritoneal cavity, whereas the blood glucose profile showed a normal pattern . We sought to learn what happens to C‐peptides as they diffuse from the peritoneal cavity to the peripheral blood.…”

Xenotransplantation literature update, July/August 2017

“…In a rodent mode, Nishimura et al interrogated the hypothesis that intraperitoneal transplantation of encapsulated pig islets provides sufficient insulin and C‐peptide levels that may not correlate with comparable levels in peripheral blood. Using athymic nude mice (to avoid any immunologic influence on graft function), the authors performed neonatal encapsulated pig islet transplantation into streptozotocin‐diabetic recipients.…”