Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish

Gonzalez, Sarah T.; Remick, Dylan; Créton, Robbert; Colwill, Ruth M.

doi:10.1016/j.neuro.2015.12.018

Cited by 31 publications

(15 citation statements)

References 116 publications

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“…The study of the consequences of pollutants exposures on behaviour has recently increased, especially for fish, in parallel to the expansion of the use of behaviour as an efficient indicator for neurotoxicity in pharmacology, toxicology, and ecotoxicology. With respect to this, we and others have shown that the exposure of fishes to pollutants using environmentally relevant exposure conditions can induce behavioural disruptions at various developmental stages (e.g., [9,10,11,12,13,14,15,16,17,18]). Other studies have shown that exposure to pollutants could modify monoamine neurotransmitter concentrations (e.g., [19,20,21,22,23]).…”

Section: Introductionmentioning

confidence: 99%

Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures

Vignet

Trenkel

Vouillarmet

et al. 2017

IJMS

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Zebrafish were exposed through diet to two environmentally relevant polycyclic aromatic hydrocarbons (PAHs) mixtures of contrasted compositions, one of pyrolytic (PY) origin and one from light crude oil (LO). Monoamine concentrations were quantified in the brains of the fish after six month of exposure. A significant decrease in noradrenaline (NA) was observed in fish exposed to both mixtures, while a decrease in serotonin (5HT) and dopamine (DA) was observed only in LO-exposed fish. A decrease in metabolites of 5HT and DA was observed in fish exposed to both mixtures. Several behavioural disruptions were observed that depended on mixtures, and parallels were made with changes in monoamine concentrations. Indeed, we observed an increase in anxiety in fish exposed to both mixtures, which could be related to the decrease in 5HT and/or NA, while disruptions of daily activity rhythms were observed in LO fish, which could be related to the decrease in DA. Taken together, these results showed that (i) chronic exposures to PAHs mixtures disrupted brain monoamine contents, which could underlie behavioural disruptions, and that (ii) the biological responses depended on mixture compositions.

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Section: Introductionmentioning

confidence: 99%

Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures

Vignet

Trenkel

Vouillarmet

et al. 2017

IJMS

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“…PCB153 induced neostriatal toxicity in adult WKY and SHR rats through changes in the monoaminergic but not amino acidergic neurotransmitter systems 49 . The effect of exposure of zebrafish larvae to a PCB mixture and Aroclor 1254 on neurodevelopment was also observed 50 . Thus, the change in these amino acids in our studies underlined the nerve-endocrine dysfunction in embryos after PCB91/149 exposure.…”

Section: Discussionmentioning

confidence: 99%

Chiral PCB 91 and 149 Toxicity Testing in Embryo and Larvae (Danio rerio): Application of Targeted Metabolomics via UPLC-MS/MS

Chai

Cui

Yin

et al. 2016

Sci Rep

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In this study, we aimed to investigate the dysfunction of zebrafish embryos and larvae induced by rac-/(+)-/(−)- PCB91 and rac-/(−)-/(+)- PCB149. UPLC-MS/MS (Ultra-performance liquid chromatography coupled with mass spectrometry) was employed to perform targeted metabolomics analysis, including the quantification of 22 amino acids and the semi-quantitation of 22 other metabolites. Stereoselective changes in target metabolites were observed in embryos and larvae after exposure to chiral PCB91 and PCB149, respectively. In addition, statistical analyses, including PCA and PLS-DA, combined with targeted metabolomics were conducted to identify the characteristic metabolites and the affected pathways. Most of the unique metabolites in embryos and larvae after PCB91/149 exposure were amino acids, and the affected pathways for zebrafish in the developmental stage were metabolic pathways. The stereoselective effects of PCB91/149 on the metabolic pathways of zebrafish embryos and larvae suggest that chiral PCB91/149 exposure has stereoselective toxicity on the developmental stages of zebrafish.

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“…Outcomes demonstrated that exposed larvae had enhanced edge preference relative to the control. Furthermore, larvae that were exposed reacted contrarily to a graphical risk comparative to control larvae [ 54 ]. Comprehensive gene expression profiles in cerebellar exhibiting the highest suggestive stimulation of anxiety-like behavior has been warranted via male mice.…”

Section: Influence Of Estrogenic Endocrine Disruptors Exposure On mentioning

confidence: 99%

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

et al. 2018

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The devastating growth in the worldwide frequency of neurocognitive disorders and its allied difficulties, such as decline in memory, spatial competency, and ability to focus, poses a significant psychological public health problem. Inhibitor of differentiation (ID) proteins are members of a family of helix-loop-helix (HLH) transcription factors. ID proteins have been demonstrated to be involved in neurodevelopmental and depressive diseases and, thus, may influence neurocognitive deficiencies due to environmental exposure. Previously, it has been demonstrated that environmental factors, such as estrogenic endocrine disruptors (EEDs), have played an essential role in the influence of various neurocognitive disorders such as Alzheimer’s, dementia, and Parkinson’s disease. Based on this increasing number of reports, we consider the impact of these environmental pollutants on ID proteins. Better understanding of how these ID proteins by which EED exposure can affect neurocognitive disorders in populations will prospectively deliver valuable information in the impediment and regulation of these diseases linked with environmental factor exposure.

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Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish

Cited by 31 publications

References 116 publications

Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures

Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures

Chiral PCB 91 and 149 Toxicity Testing in Embryo and Larvae (Danio rerio): Application of Targeted Metabolomics via UPLC-MS/MS

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

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