Effects of electromagnetic radiation from a cellular telephone on the oxidant and antioxidant levels in rabbits

Abstract

The number of reports on the effects induced by electromagnetic radiation (EMR) in various cellular systems is still increasing. Until now no satisfactory mechanism has been proposed to explain the biological effects of this radiation. Oxygen free radicals may play a role in mechanisms of adverse effects of EMR. This study was undertaken to investigate the influence of electromagnetic radiation of a digital GSM mobile telephone (900 MHz) on oxidant and antioxidant levels in rabbits. Adenosine deaminase, xanthine oxidase, catalase, myeloperoxidase, superoxide dismutase (SOD) and glutathione peroxidase activities as well as nitric oxide (NO) and malondialdehyde levels were measured in sera and brains of EMR-exposed and sham-exposed rabbits. Serum SOD activity increased, and serum NO levels decreased in EMR-exposed animals compared to the sham group. Other parameters were not changed in either group. This finding may indicate the possible role of increased oxidative stress in the pathophysiology of adverse effect of EMR. Decreased NO levels may also suggest a probable role of NO in the adverse effect.

The effects of electromagnetic radiation (2450 MHz wireless devices) on the heart and blood tissue: role of melatonin

“…They found that compared to the sham group, the serum SOD activity in EMR-exposed animals increased, whereas their NO levels decreased. Researchers suggest that this fi nding may indicate that EMR disrupts the pathophysiology of blood by increasing levels of oxidative stress (46). All of these fi ndings mentioned above were similar to the results in this study.…”

Effects of exposure to a mobile phone on sexual behavior in adult male rabbit: an observational study

“…28 Second, the MPs used in this study had a carrier frequency of 800 MHz and the animal model used was the rabbit. A large number of studies have reported the occurrence of oxidative stress in brain tissues with the use of MPs with a similar carrier frequency and the same animal model 29 or other close rodents such as rats. 22 Third, the same group of MP animals represented the subjects of another two studies.…”

Effects of Computer Use on Human Salivary Oxidant/Antioxidant Status

“…Recent studies indicated that reactive oxygen species (ROS) such as superoxide anion, which is predominantly generated by the mitochondria; hydrogen peroxide produced from superoxide anion by the action of superoxide dismutase , and peroxynitrite, generated by the reaction of superoxide anion with nitric oxide have been implicated in tissue injury. The main ROS that have to be considered are oxygen species ones [7,8] which are scavenged by some enzymes such as SOD, GSH-Px and CAT. When the balance of antioxidants is outweighed by excessively produced ROS as a result of overproduction of oxygen radicals, inactivation of detoxification systems, consumption of antioxidants, and failure to adequately replenish antioxidants in tissue, these endogenous antioxidative defences system are likely to be perturbed.…”

“…It has been shown in numerous studies that ROS are directly involved in oxidative damage of cellular macromolecules such as lipids, proteins, and nucleic acids in tissues. Malondialdehyde is a breakdown product of the major chain reactions leading to oxidation of polyunsaturated fatty acids and thus serves as a reliable marker of oxidative stress [8,9] . Adenosine deaminase is known as an important enzyme that participates in the degradative pathways of adenosine monophosphate [10] .…”