Effects of electrical lesions of the medial preoptic area and the ventral pallidum on mate-dependent paternal behavior in mice

Akther, Shirin; Fakhrul, Azam A. K. M.; Higashida, Haruhiro

doi:10.1016/j.neulet.2014.03.078

Cited by 23 publications

(13 citation statements)

References 29 publications

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“…We have recently reported that central cholinergic cellular signaling (Fujimoto et al, 2013) and CD38 and oxytocin signaling in the nucleus accumbens (NAcc) (Akther et al, 2013) are critical for the expression of paternal care of the ICR mice. We also demonstrated the modulatory roles of the mPOA and VP on parental behavior in rodents (Akther et al, 2014). These published findings suggest that the neural circuitry mediating paternal behavior includes the mPOA, VTA, NAcc, and VP, and may be similar to those that mediate maternal behavior as proposed by Numan and others (Numan et al, 2005; Lee and Brown, 2007; Wynne-Edwards and Timonin, 2007; Numan and Stolzenberg, 2009).…”

Section: Discussionmentioning

confidence: 52%

Pairmate-dependent pup retrieval as parental behavior in male mice

et al. 2014

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Appropriate parental care by fathers can greatly facilitate healthy human family life. However, much less is known about paternal behavior in animals compared to those regarding maternal behavior. Previously, we reported that male ICR strain laboratory mice, although not spontaneously parental, can be induced to display maternal-like parental care (pup retrieval) when separated from their pups by signals from the pairmate dam (Liu et al., 2013). This parental behavior by the ICR sires, which are not genetically biparental, is novel and has been designated as pairmate-dependent paternal behavior. However, the factors critical for this paternal behavior are unclear. Here, we report that the pairmate-dependent paternal retrieval behavior is observed especially in the ICR strain and not in C57BL/6 or BALB/c mice. An ICR sire displays retrieval behavior only toward his biological pups. A sire co-housed with an unrelated non-pairing dam in a new environment, under which 38-kHz ultrasonic vocalizations are not detected, does not show parenting behavior. It is important for sires to establish their own home territory (cage) by continuous housing and testing to display retrieval behavior. These results indicated that the ICR sires display distinct paternity, including father-child social interaction, and shed light on parental behavior, although further analyses of paternal care at the neuroendocrinological and neurocircuitry levels are required.

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Section: Discussionmentioning

confidence: 52%

Pairmate-dependent pup retrieval as parental behavior in male mice

et al. 2014

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“…MPOA neural activity is essential for maternal motivation in virgin and postpartum laboratory mice (Akther et al, 2014; Tsuneoka et al, 2013; Wu et al, 2014), as is the OTR, since mutant female mice with a knockout mutation of the OTR show deficits in the onset of maternal behavior (Rich et al, 2014; Takayanagi et al, 2005). There is also evidence that the MPOA may promote BMA/BLA input to VP in the regulation of maternal behavior in mice (Akther et al, 2014; Okabe et al, 2013; also see Lee & Brown, 2007), and that OT may act at the level of NA to influence such behavior (Akther et al, 2013; Jin et al, 2007; cf.…”

Section: Maternal Behavior and Mother-infant Attachmentmentioning

confidence: 99%

“…There is also evidence that the MPOA may promote BMA/BLA input to VP in the regulation of maternal behavior in mice (Akther et al, 2014; Okabe et al, 2013; also see Lee & Brown, 2007), and that OT may act at the level of NA to influence such behavior (Akther et al, 2013; Jin et al, 2007; cf. Dolen et al, 2013).…”

Section: Maternal Behavior and Mother-infant Attachmentmentioning

confidence: 99%

Neural mechanisms of mother–infant bonding and pair bonding: Similarities, differences, and broader implications

Numan¹,

Young

2016

Hormones and Behavior

284

278

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Mother-infant bonding is a characteristic of virtually all mammals. The maternal neural system may have provided the scaffold upon which other types of social bonds in mammals have been built. For example, most mammals exhibit a polygamous mating system, but monogamy and pair bonding between mating partners occurs in ∼5% of mammalian species. In mammals, it is plausible that the neural mechanisms that promote mother-infant bonding have been modified by natural selection to establish the capacity to develop a selective bond with a mate during the evolution of monogamous mating strategies. Here we compare the details of the neural mechanisms that promote mother-infant bonding in rats and other mammals with those that underpin pair bond formation in the monogamous prairie vole. Although details remain to be resolved, remarkable similarities and a few differences between the mechanisms underlying these two types of bond formation are revealed. For example, amygdala and nucleus accumbens-ventral pallidum (NA-VP) circuits are involved in both types of bond formation, and dopamine and oxytocin action within NA appears to promote the synaptic plasticity that allows either infant or mating partner stimuli to persistently activate NA-VP attraction circuits, leading to an enduring social attraction and bonding. Further, although the medial preoptic area is essential for maternal behavior, its role in pair bonding remains to be determined. Our review concludes by examining the broader implications of this comparative analysis, and evidence is provided that the maternal care system may have also provided the basic neural foundation for other types of strong social relationships, beyond pair bonding, in mammals, including humans.

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“…In Mus, fathers that behave more paternally toward unrelated pups have greater fos expression in the MPOA following pup exposure than males that exhibit less allopaternal behavior (Tsuneoka et al 2015). Stimulation of the MPOA increases paternal care, while lesions decrease paternal and allopaternal care, including mate-dependent paternal care, in Mus (Akther et al 2014;Tsuneoka et al 2015). Similarly, MPOA lesions in male rats prevent and disrupt pup-induced (i.e., sensitized) allopaternal behavior (Rosenblatt et al 1996;Sturgis and Bridges 1997).…”

Section: Medial Preoptic Areamentioning

confidence: 99%

Neural Regulation of Paternal Behavior in Mammals: Sensory, Neuroendocrine, and Experiential Influences on the Paternal Brain

Horrell

Hickmott

Saltzman

2018

Neuroendocrine Regulation of Behavior

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Across the animal kingdom, parents in many species devote extraordinary effort toward caring for offspring, often risking their lives and exhausting limited resources. Understanding how the brain orchestrates parental care, biasing effort over the many competing demands, is an important topic in social neuroscience. In mammals, maternal care is necessary for offspring survival and is largely mediated by changes in hormones and neuropeptides that fluctuate massively during pregnancy, parturition, and lactation (e.g., progesterone, estradiol, oxytocin, and prolactin). In the relatively small number of mammalian species in which parental care by fathers enhances offspring survival and development, males also undergo endocrine changes concurrent with birth of their offspring, but on a smaller scale than females. Thus, fathers additionally rely on sensory signals from their mates, environment, and/or offspring to orchestrate paternal behavior. Males can engage in a variety of infant-directed behaviors that range from infanticide to avoidance to care; in many species, males can display all three behaviors in their lifetime. The neural plasticity that underlies such stark changes in behavior is not well understood. In this chapter we summarize current data on the neural circuitry that has been proposed to underlie paternal care in mammals, as well as sensory, neuroendocrine, and experiential influences on paternal behavior and on the underlying circuitry. We highlight some of the gaps in our current knowledge of this system and propose future directions that will enable the development of a more comprehensive understanding of the proximate control of parenting by fathers.

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Effects of electrical lesions of the medial preoptic area and the ventral pallidum on mate-dependent paternal behavior in mice

Cited by 23 publications

References 29 publications

Pairmate-dependent pup retrieval as parental behavior in male mice

Pairmate-dependent pup retrieval as parental behavior in male mice

Neural mechanisms of mother–infant bonding and pair bonding: Similarities, differences, and broader implications

Neural Regulation of Paternal Behavior in Mammals: Sensory, Neuroendocrine, and Experiential Influences on the Paternal Brain

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