Effects of electrical and chemical stimulation of nucleus raphe magnus on responses to renal nerve stimulation

Knuepfer, Mark M.; Holt, I. Lee

doi:10.1016/0006-8993(91)90045-w

Cited by 10 publications

(3 citation statements)

References 33 publications

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“…The VMM modulates visceral as well as cutaneous inputs (Chapman et al, 1985;Tattersall et al, 1986;Holt et al, 1991;Knuepfer and Holt, 1991;. Because bladder contractions increase in frequency and size with increasing bladder pressure, require supraspinal input, and are inhibited by RM stimulation (Sugaya et al, 1998), RM may inhibit bladder afferent input.…”

Section: Introductionmentioning

confidence: 99%

Roles for Pain Modulatory Cells during Micturition and Continence

Baez¹,

Brink²,

Mason³

2005

J. Neurosci.

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Section: Introductionmentioning

confidence: 99%

Roles for Pain Modulatory Cells during Micturition and Continence

Baez¹,

Brink²,

Mason³

2005

J. Neurosci.

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“…Outputs from the cervical spinal tract project to the autonomic region of the vestibular nuclei. The reticular formation, including the lateral reticular nucleus (LRt), projects directly to the vestibular nuclei (Jian et al, ) and receives inputs from visceral and somatosensory receptors (Ammons, ; Blair, ; Drew et al, ; Fields et al, ; Peterson et al, ; Schulz et al, ; Thies, ; Yates and Stocker, ) as well as from the raphe nucleus (Blair and Evans, ; Knuepfer and Holt, ; Lumb and Morrison, ), whereby visceral and somatosensory information is integrated.…”

Section: Discussionmentioning

confidence: 99%

TheFoxb1‐expressing neurons of the ventrolateral hypothalamic parvafox nucleus project to defensive circuits

Bilella

Álvarez-Bolado

Celio

2016

J of Comparative Neurology

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The parvafox nucleus is an elongated structure that is lodged within the ventrolateral hypothalamus and lies along the optic tract. It comprises axially located parvalbumin (Parv)-positive neurons and a peripheral cuff of Foxb1-expressing ones. In the present study, injections of Cre-dependent adenoviral constructs were targeted to the ventrolateral hypothalamus of Foxb1/Cre mice to label specifically and map the efferent connections of the Foxb1-expressing subpopulation of neurons of the parvafox nucleus. These neurons project more widely than do the Parv-positive ones and implicate a part of the axons known to emanate from the lateral hypothalamus. High labeling densities were found in the dorsolateral and the upper lateral portion of the periaqueductal gray (PAG), the Su3 and PV2 nuclei of the ventrolateral PAG, the cuneiform nucleus, the mesencephalic reticular formation, and the superior colliculus. Intermediate densities of terminals were encountered in the septum, bed nucleus of the stria terminalis, substantia innominata, various thalamic and hypothalamic nuclei, pedunculopontine nucleus, Barrington's nucleus, retrofacial nucleus, and retroambigual nucleus. Scattered terminals were observed in the olfactory bulbs, the prefrontal cortex and the lamina X of the cervical spinal cord. Because the terminals were demonstrated to express the glutamate transporter VGlut2, the projections are presumed to be excitatory. A common denominator of the main target sites of the Foxb1-positive axons of the parvafox nucleus appears to be an involvement in the defensive reactions to life-threatening situations. The hypothalamic parvafox nucleus may contribute to the autonomic manifestations that accompany the expression of emotions. J. Comp. Neurol. 524:2955-2981, 2016. © 2016 Wiley Periodicals, Inc.

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“…Relatively few studies have examined descending modulatory influences on visceroceptive spinal neurons. Some studies have addressed tonic influences (e.g., Akeyson et al 1990;Standish et al 1992;Tattersall et al 1986) and others stimulation-produced inhibition of spinal visceral transmission (Ammons et al 1984(Ammons et al , 1986Chandler et al 1989;Chapman et al 1985;Gielser and Liebeskind 1976;Knuepfer and Holt 1991;Lumb 1990;Ness and Gebhart 1987;Okada et al 1999). In previous work, we Gebhart 1992, 1997) characterized descending influences from the RVM on noxious cutaneous stimuli, documenting the presence of facilitatory and inhibitory modulation of nociceptive transmission.…”

Section: Introductionmentioning

confidence: 89%

Biphasic Modulation of Spinal Visceral Nociceptive Transmission From the Rostroventral Medial Medulla in the Rat

Zhuo

Sengupta

Gebhart

2002

Journal of Neurophysiology

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Descending inhibitory and facilitatory influences from the rostroventral medulla (RVM) on responses of lumbosacral spinal neurons to noxious colorectal distension (CRD, 80 mmHg, 20 s) were studied. At 25 sites in the RVM, electrical stimulation produced biphasic effects, facilitating responses of spinal neurons to CRD at lesser intensities of stimulation (5-25 microA) and inhibiting responses of the same neurons at greater intensities of stimulation (50-100 microA). At 38 other sites in the RVM, electrical stimulation produced only intensity-dependent inhibition of neuron responses to CRD. At another 13 sites in the RVM, electrical stimulation (5-100 microA) produced only facilitatory effects on responses to CRD. Descending modulatory effects were selective for distension-evoked activity; spontaneous activities of the same spinal neurons were not significantly affected by electrical stimulation that either facilitated or inhibited neuron responses to CRD. Neuron responses to graded CRD (20-100 mmHg) were positively accelerating functions that were shifted leftward or rightward, respectively, by lesser, facilitatory intensities or greater, inhibitory intensities of RVM stimulation. L-glutamate microinjection into the RVM replicated the effects of electrical stimulation, producing similar biphasic modulatory effects as produced by electrical stimulation. Microinjection of glutamate into the RVM at a low dose (5 nmoles) facilitated responses of spinal neurons to CRD and inhibited responses of the same neurons at a greater dose (50 nmoles). In some experiments, microinjection of lidocaine (0.5 microl of 4% solution) or the neurotoxin ibotenic acid (0.5 microl, 10 microg) into the RVM produced reversible or long-lasting, respectively, decreases in spontaneous activity and responses of spinal neurons to CRD. These results reveal that spinal visceral nociceptive transmission is subject to a tonic descending excitatory influence from the RVM and that descending modulatory effects from the RVM on visceral nociceptive transmission are qualitatively similar to modulation of cutaneous nociceptive transmission.

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Effects of electrical and chemical stimulation of nucleus raphe magnus on responses to renal nerve stimulation

Cited by 10 publications

References 33 publications

Roles for Pain Modulatory Cells during Micturition and Continence

Roles for Pain Modulatory Cells during Micturition and Continence

TheFoxb1‐expressing neurons of the ventrolateral hypothalamic parvafox nucleus project to defensive circuits

Biphasic Modulation of Spinal Visceral Nociceptive Transmission From the Rostroventral Medial Medulla in the Rat

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