Effects of Elasticity on Cell Proliferation in a Tissue-Engineering Scaffold Pore

Annunziata, Carlyn; Fattahpour, Haniyeh; Fong, Daniel; Hadjiargyrou, Michael; Sanaei, Pejman

doi:10.1007/s11538-023-01134-7

Search citation statements

Order By: Relevance

Paper Sections

Select...

Elasticity Relationship With Mechanical Cellular Properties1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mechanical cellular properties and elasticity include adhesion, 7,24 viscosity, 25–27 migration, 28–30 proliferation, 31–33 and differentiation. 34 Elasticity and stiffness, for example, play crucial roles in cell destiny and function.…”

Section: Elasticity Relationship With Mechanical Cellular Propertiesmentioning

confidence: 99%

Cellular elasticity in cancer: a review of altered biomechanical features

Radman,

Alhameed,

Shu

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Section: Elasticity Relationship With Mechanical Cellular Propertiesmentioning

confidence: 99%

Cellular elasticity in cancer: a review of altered biomechanical features

Radman,

Alhameed,

Shu

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Effects of nutrient concentration and scaffold elasticity on the tissue growth in a tissue engineering scaffold channel

Fattahpour,

Sanaei

2023

Physics of Fluids

View full text Add to dashboard Cite

Tissue-engineering scaffolds contain channels lined by cells that allow nutrient-rich culture medium to pass through to encourage cell proliferation. Several factors have significant impacts on the tissue growth, including the nutrient flow rate, concentration in the feed, scaffold elasticity, and cell properties. Recent studies have investigated these effects separately; however, in this work, we examine all of them simultaneously. Our objectives in this work are as follows: (i) developing a mathematical model describing the nutrient flow dynamics and concentration, scaffold elasticity, and cell proliferation; (ii) solving the model and then simulating the cell proliferation process; and (iii) optimizing the initial configuration of the scaffold channels to maximize the cell growth. The results of our study demonstrate that the rate of nutrient consumption by the cells (cell hunger rate) and the scaffold elastic compliance have an impact on tissue growth, with higher cell hunger rates leading to longer incubation periods, while scaffold elastic compliance slightly affects overall growth. Furthermore, decreasing the scaffold elastic compliance while maintaining a constant nutrient consumption rate results in an optimal funnel-shaped channel geometry, where the upper part of the channel is larger than the downstream, promoting enhanced tissue integration and functionality.

show abstract

Effects of Elasticity on Cell Proliferation in a Tissue-Engineering Scaffold Pore

Cited by 2 publications

References 60 publications

Cellular elasticity in cancer: a review of altered biomechanical features

Cellular elasticity in cancer: a review of altered biomechanical features

Effects of nutrient concentration and scaffold elasticity on the tissue growth in a tissue engineering scaffold channel

Contact Info

Product

Resources

About