Effects of EHD2 interference on migration of esophageal squamous cell carcinoma

Li, Mei; Yang, Xiaojing; Zhang, Jianguo; Shi, Hui; Hang, Qinglei; Huang, Xing‐Huai; Liu, Guoliang; Zhu, Junya; He, Song; Wang, Huijie

doi:10.1007/s12032-012-0396-4

Cited by 33 publications

(31 citation statements)

References 22 publications

(21 reference statements)

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“…Cell motility and invasion are essential features of the metastatic process (Li et al 2013a). Identifying the molecules and pathways that control cell motility and invasion is critical to understanding cancer metastasis.…”

Section: Discussionmentioning

confidence: 99%

Up-regulation of SPOCK1 induces epithelial–mesenchymal transition and promotes migration and invasion in esophageal squamous cell carcinoma

et al. 2015

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Invasion and metastasis are the major causes of death in patients with esophageal squamous cell carcinoma (ESCC). Recent studies have confirmed that SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 1 (SPOCK1) plays multiple roles in cancer progression. This study aims to explore the clinical characteristics of SPOCK1 in ESCC and its roles in the migration and invasion of ESCC cell lines. In this study, the up-regulation of SPOCK1 expression was frequently detected in primary ESCC tumor tissues compared with those in non-tumor tissues, which was significantly associated with tumor invasion (p = 0.004) and distant metastasis (p = 0.010). SPOCK1 was expressed at higher level in TE13 cells as compared to the low malignant Eca109 and TE1 cells. Overexpression of SPOCK1 in Eca109 cells decreased the expressions of epithelial marker E-cadherin and ZO-1, while increased mesenchymal marker Vimentin and N-cadherin levels. After ectopic expression of SPOCK1, Eca109 cells exhibited a morphological change from an epithelial cobblestone phenotype to an elongated fibroblastic phenotype, concomitant with cytoskeletal rearrangements and increased migration and invasion, suggesting that EMT occurs. While silencing SPOCK1 in TE13 cells had the opposite effects. These results suggest that up-regulation of SPOCK1 in ESCC induces EMT, thus promotes migration and invasion in ESCC cells.

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Section: Discussionmentioning

confidence: 99%

Up-regulation of SPOCK1 induces epithelial–mesenchymal transition and promotes migration and invasion in esophageal squamous cell carcinoma

et al. 2015

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“…Under-expression of EHD2 increased the motility property of ESCC cell TE1 in vitro. [141] Under-expression of EHD2 has also been reported in malignant serous ovarian cancer samples. [142] A new mechanical role for caveolae in cancer?…”

Section: Caveolae New Partners and Cancermentioning

confidence: 96%

Caveolae and cancer: A new mechanical perspective

Lamaze¹,

Torrino²

2015

Biomed J

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“…Tissues with no staining were rated as 0, with a faint staining or moderate to strong staining in ≤25% of cells as 1, with a moderate staining in 25-50% of cells as 2, with strong staining ≥50% of cells as 3. For statistical analysis, <2 was regarded as low expression and ≥2 as overexpression [20].…”

Section: Immunohistochemistry (Ihc)mentioning

confidence: 99%

“…In this study, we detected the expression of AGS3 in ESCC patients and the potential functional relationship in tumor proliferation and prognosis. To examine the potential tumor-suppressive activity of AGS3in ESCC, AGS3 was transfected into a common ESCC cell line, TE1 [20]. Overexpression of AGS3 caused the proliferation of esophageal squamous cells TE1 to decrease significantly.…”

Section: Introductionmentioning

confidence: 99%