1964
DOI: 10.2170/jjphysiol.14.135
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Effects of ‘Edta’ on the Membrane Potential and Tension of Ventricular Muscle of the Rabbit

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Cited by 19 publications
(4 citation statements)
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“…When 2-5 HIM disodium ethylenediamine tetraacetate (EDTA) was added to one compartment of the muscle chamber, the action potential duration recorded in that compartment was prolonged and the action potential spike diminished in a few minutes (Fig. 2), as has been reported by others (7,8). In the Purkinje fiber-papillary muscle preparation, EDTA was added to the compartment containing the Purkinje fiber.…”
Section: Resultssupporting
confidence: 54%
“…When 2-5 HIM disodium ethylenediamine tetraacetate (EDTA) was added to one compartment of the muscle chamber, the action potential duration recorded in that compartment was prolonged and the action potential spike diminished in a few minutes (Fig. 2), as has been reported by others (7,8). In the Purkinje fiber-papillary muscle preparation, EDTA was added to the compartment containing the Purkinje fiber.…”
Section: Resultssupporting
confidence: 54%
“…Similar action potentials produced in low or zero calcium with a chelator has been also observed in cardiac muscle fibers (CHANG and SCHMIDT, 1960;GOTO and ABE, 1964;GARNIER et al, 1969;TRITTHART et al, 1973;MILLER and MORCHEN, 1978) and in smooth muscle fibers (PROSSER et al, 1977).…”
supporting
confidence: 73%
“…In heart muscle fibers, the duration of an action potential observed in zero calcium with a chelator was dependent on the extracellular sodium concentrations; the increase in sodium concentration prolonged the plateau phase and the decrease in it acts contrarily (GOTO and ABE, 1964;GARNIER et a!., 1969). GARNIER et al (1969) reported that the existence of a slow inward sodium current, which was blocked by the action of magnesium, was responsible for long duration of response in frog atrial muscle fibers.…”
Section: Discussionmentioning
confidence: 99%
“…8 (A)). It is suspected that in the presence of EGTA, not only the membrane Ca but also the Ca in the interior of the cell membrane are depleted (GOTO and ABE, 1964). From these experimental results it might be assumed that the Ca for activating the tonic contraction of the delayed effect is released from the Ca binding sites in the cell membrane.…”
Section: Discussionmentioning
confidence: 96%