Effects of ecologically relevant concentrations of cadmium in a freshwater fish

Pereira, Letícia; Ribas, João Luiz Coelho; Vicari, Taynah; Silva, S.B.; Stival, João Felipe; Baldan, Ana Paula; Domingos, Fabíola Xochilt Valdez; Grassi, Marco Tadeu; Cestari, Marta Margarete; Assis, Helena C. Silva de

doi:10.1016/j.ecoenv.2016.03.046

Cited by 64 publications

(16 citation statements)

References 64 publications

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“…Also, any local surge in anthropogenic activity could easily increase the bioavailability of Cd. In fact, other studies consider the range we have used in the current study to be ecologically relevant (Pereira et al 2016). This validates our model system and experimental approach, particularly given the observed differences in heart rate and behavior at lower concentrations.…”

Section: Discussionmentioning

confidence: 98%

The longitudinal effects of early developmental cadmium exposure on conditioned place preference and cardiovascular physiology in zebrafish

et al. 2017

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Cadmium (Cd) is a naturally occurring trace metal that is widely considered to be highly toxic to aquatic organisms and a significant health hazard to humans (Amzal et al 2009; Bernhoft 2013; Burger 2008; Satarug et al 2009). The zebrafish (Danio rerio) has been used as a model organism for toxicological studies with Cd (Banni et al 2011; Blechinger et al 2007; Chow et al 2009; Chow et al 2008; Favorito et al 2011; Kusch et al 2007; Matz et al 2007; Wang & Gallagher 2013). We asked what the lasting longitudinal effects would be from short early developmental Cd exposure (between 24-96 hours post-fertilization) in a range that larvae might experience living atop typical Cd-containing surface sediments (0, 0.01, 0.1, 1.0 and 10 μM CdCl2: 1.124, 11.24, 112.4 and 1124 μg Cd/L). The goal of this exposure window was to specifically target secondary neurogenesis, monoaminergic differentiation and cardiovascular development, without affecting earlier patterning processes. Developmental abnormalities in body size and CNS morphology increased with concentration, but were statistically significant only at the highest concentration used (10 μM). Heart rate for Cd-treated larvae increased with concentration, and was significant even at the lowest concentration used (0.01 μM). Longitudinal survival was significantly lower for fish developmentally exposed to the highest concentration. Except for brain weight, overall morphology was not affected by developmental Cd exposure. However, developmental exposure to lower concentrations of Cd (0.01, 0.1, and 1.0 μM) progressively lowered cocaine-induced conditioned place preference (CPP), used to measure function of the reward pathways in the brain. Baseline heart rate was significantly lower in longitudinal fish developmentally exposed to 1.0 μM Cd. Cardiovascular response to isoproterenol, a potent β-adrenergic agonist, in longitudinal adults was also significantly affected by developmental exposure to Cd at low doses (0.01, 0.1 and 1.0 μM). Surviving longitudinal adult fish exposed to the highest concentration of Cd showed normal CPP and cardiovascular physiology. The data imply that even lower exposure concentrations can potentially result in fitness-affecting parameters without affecting survival in a laboratory setting.

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Section: Discussionmentioning

confidence: 98%

The longitudinal effects of early developmental cadmium exposure on conditioned place preference and cardiovascular physiology in zebrafish

et al. 2017

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“…Further, three single mutants of SpArsM abolished the capability of As (III) methylation, suggesting the three cysteine residues are involved in catalysis. Authors conclude that SpArsM is responsible for As methylation and detoxification of As Rhamdia quelen were studied by Pereira et al, (2016). The fish were exposed to Cd (0, 0.1, 1, 10 and 100 μg L −1 ) for 15 days.…”

Section: Metalsmentioning

confidence: 99%

Effects of Pollution on Freshwater Organisms

Choudri

Baawain²

2017

Water Environment Research

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This review covers research papers and scientific literature published in the year 2016 on the effects of anthropogenic pollutants on freshwater organisms. In the first, the review begins with two broad sections thate are mainly focused on research reviews and broad field studies and surveys. This is followed by reviews of research categorized in sections to reflect the pollutant class. These sections include wastewater, stormwater and non-point source pollution, nutrients, sediment cap materials and suspended clays, botanical extracts, surfactants, metals, persistent organic pollutants, pharmaceuticals, endocrine disruptors, pesticides, petroleum hydrocarbons and polycyclic aromatic hydrocarbons (PAHs), ionic liquids, and nanomaterials. The final section of the review highlights the research published on describing innovations in the field of freshwater pollution research.

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“…In polluted areas, well-water cadmium concentration could exceed 0.025 mg L −1 [5,6]. On the other hand, speaking in terms of threshold values, while the European Union directive posed it 0.005 mg L −1 for drinking water [7], other countries like Brazil allowed the threshold to be set 0.01 mg L −1 for freshwater [8]. Moreover, besides smoking habit and alcohol consumption, diet plays an important role in humans being vegetables able to accumulate cadmium whose environmental levels need to be maintained under control [9].…”

Section: Introductionmentioning

confidence: 99%

Suitability of a Cellulose-Based Nanomaterial for the Remediation of Heavy Metal Contaminated Freshwaters: A Case-Study Showing the Recovery of Cadmium Induced DNA Integrity Loss, Cell Proliferation Increase, Nuclear Morphology and Chromosomal Alterations on Dreissena polymorpha

et al. 2020

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The contamination of freshwaters by heavy metals represents a great problem, posing a threat for human and environmental health. Cadmium is classified as carcinogen to humans and its mechanism of carcinogenicity includes genotoxic events. In this study a recently developed eco-friendly cellulose-based nanosponge (CNS) was investigated as a candidate in freshwater nano-remediation process. For this purpose, CdCl2 (0.05 mg L−1) contaminated artificial freshwater (AFW) was treated with CNS (1.25 g L−1 for 2 h), and cellular responses were analyzed before and after CNS treatment in Dreissena polymorpha hemocytes. A control group (AFW) and a negative control group (CNS in AFW) were also tested. DNA primary damage was evaluated by Comet assay while chromosomal damage and cell proliferation were assessed by Cytome assay. AFW exposed to CNS did not cause any genotoxic effect in zebra mussel hemocytes. Moreover, DNA damage and cell proliferation induced by Cd(II) turned down to control level after 2 days when CNS were used. A reduction of Cd(II)-induced micronuclei and nuclear abnormalities was also observed. CNS was thus found to be a safe and effective candidate in cadmium remediation process being efficient in metal sequestering, restoring cellular damage exerted by Cd(II) exposure, without altering cellular physiological activity.

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Effects of ecologically relevant concentrations of cadmium in a freshwater fish

Cited by 64 publications

References 64 publications

The longitudinal effects of early developmental cadmium exposure on conditioned place preference and cardiovascular physiology in zebrafish

The longitudinal effects of early developmental cadmium exposure on conditioned place preference and cardiovascular physiology in zebrafish

Effects of Pollution on Freshwater Organisms

Suitability of a Cellulose-Based Nanomaterial for the Remediation of Heavy Metal Contaminated Freshwaters: A Case-Study Showing the Recovery of Cadmium Induced DNA Integrity Loss, Cell Proliferation Increase, Nuclear Morphology and Chromosomal Alterations on Dreissena polymorpha

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