Effects of Early Treatment With Statins on Short-term Clinical Outcomes in Acute Coronary Syndromes

Abstract

Based on available evidence, initiation of statin therapy within 14 days following onset of ACS does not reduce death, MI, or stroke up to 4 months.

Benefit of Early Statin Therapy in Patients With Acute Myocardial Infarction Who Have Extremely Low Low-Density Lipoprotein Cholesterol

“…We also analyzed the clinical outcome at 1 month, and there were no significant differences in the primary endpoint between the groups. This is consistent with and expands on 2 meta-analyses (20,21), both of which also showed that beneficial effects of statins were apparent only after more than 4 months.…”

Prognostic impact of intensive statin therapy on N‐terminal pro‐BNP level in non‐ST‐segment elevation acute myocardial infarction patients

“…As regards the impact of intensive statin therapy on cardiovascular morbidity and mortality and in concordance with the present study; Choudhry et al had shown the non‐superiority of intensive statin therapy in decreasing incidence of MACE in elderly patients with ACS after a long term follow‐up period . Also, a meta‐analysis of randomized controlled trials failed to demonstrate a reduction in the composite primary end point (death, myocardial infarction, or stroke) after 1 and 4 months in ACS patients treated early with intensive doses of statins . On the other hand, PROVE IT–TIMI 22 trial showed that intensive statin therapy after ACS was associated with major protection against MACE after a follow‐up period of 24 months.…”

The Effect of Early, Intensive Statin Therapy on Acute Coronary Syndrome

“…Our findings are similar to and extend on a recent meta-analysis ex-ploring the effects of statin use in ACS. 34 Similar to our findings, Briel et al 34 found no evidence of benefit through 4 months. This may not be a surprising finding since 1 potential benefit of statins may be plaque stabilization, which may take several months to occur.…”