Effects of Early Therapeutic Administration of Interleukin-1β on Survival Rate and Bone Marrow Hemopoiesis of Irradiated Mice

Grebenyuk, Alexander; Zatsepin, Victor; Aksenova, Natalia V.; Timoshevsky, Alexander

doi:10.14712/18059694.2016.80

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…One of perspective approaches to the enhancement of the organism of radioresistance is using of stimulators of haemopoiesis and immunity (Lukashin 2007;Grebenyuk et al 2010). Heparin/heparan sulfate modulated the biological activity of growth factors and cytokines (Harmer 2006;Mulloy and Rider 2006).…”

Section: Introductionmentioning

confidence: 99%

Radioprotective Effect of Heparin

Lukashin¹,

Grebenyuk²,

Zatsepin³

2011

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The study was aimed at the experimental assessment of the efficacy of heparin as radioprotector in condition of acute whole body γ-ray irradiation. The efficacy of the product was based on the 30-day survival rate and average life expectancy of dead irradiated animals. To reveal possible mechanisms of radioprotective effects of heparin the thymus mass, the number of leukocytes and colony formation units (CFU) in the peripheral blood and bone marrow were studied. It was shown that radioprotective effect of heparin administered intraperitoneally in a dose of 250 unit/kg was developed within one day after the administration and maintained for periods up to 30 days. Heparin increased the survival rate only in radiosensitive BALB/c and inbred mice. The product exerted stimulating effects on the migration of haemopoietic cells: injection of heparin doubled the number of CFU in the peripheral blood of BALB/c mice and reliably reduced it in the bone marrow.

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Section: Introductionmentioning

confidence: 99%

Radioprotective Effect of Heparin

Lukashin¹,

Grebenyuk²,

Zatsepin³

2011

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A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice

Cheda

Nowosielska

Gębicki

et al. 2021

Sci Rep

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Most, if not all, of the hitherto tested substances exert more or less pronounced pro-survival effects when applied before or immediately after the exposure to high doses of ionizing radiation. In the present study we demonstrate for the first time that 1-methyl nicotinamide (MNA), a derivative of vitamin B3, significantly (1.6 to 1.9 times) prolonged survival of BALB/c mice irradiated at LD30/30 (6.5 Gy), LD50/30 (7.0 Gy) or LD80/30 (7.5 Gy) of γ-rays when the MNA administration started as late as 7 days post irradiation. A slightly less efficient and only after the highest dose (7.5 Gy) of γ-rays was another vitamin B3 derivative, 1-methyl-3-acetylpyridine (1,3-MAP) (1.4-fold prolonged survival). These pro-survival effects did not seem to be mediated by stimulation of haematopoiesis, but might be related to anti-inflammatory and/or anti-thrombotic properties of the vitamin B3 derivatives. Our results show that MNA may represent a prototype of a radioremedial agent capable of mitigating the severity and/or progression of radiation-induced injuries when applied several hours or days after exposure to high doses of ionizing radiation.

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Age Dependence of Hematopoietic Progenitor Survival and Chemokine Family Gene Induction after Gamma Irradiation in Bone Marrow Tissue in C3H/He Mice

Ariyoshi¹,

Tsuruo²,

Shinagawa³

et al. 2014

Radiation Research

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Age at exposure is a critical factor that influences the risk of radiation-induced leukemia, which arises from hematopoietic stem and progenitor cells. However, little is known about the effect of age on the radiation response of these cells. In this study, we examined the radiation response of hematopoietic stem and progenitor cells in infant (1-week-old), juvenile (3-week-old), and adult (8- and 14-week-old) C3H/He mice, which are susceptible to radiation-induced myeloid leukemia. We first observed an age-dependent increase in the radioresistance of hematopoietic stem and progenitor cells after in vivo irradiation. However, in vitro irradiation of progenitor cells did not show any age differences, suggesting that radiation sensitivity in vivo is dependent on the bone marrow microenvironment rather than to intrinsic properties of progenitors themselves. Expression profiles of bone marrow tissues identified chemokine and cytokine family genes, whose expression differed between infant and adult tissues at time points before and after irradiation. Among the selected thirteen cytokines reported to be radioprotective, we observed increased expression of Csf1, Csf2, Cxcl12, Fgf1, Fgf7, Il1a, Il1b and Kitl after irradiation, mostly in adult tissues. Specifically, Csf2, Fgf1 and Il1b expression, as revealed by qPCR, were significantly enhanced in adult bone marrow tissue after irradiation, but were unresponsive to irradiation in infant tissue. These results suggest that the higher susceptibility of infant hematopoietic stem and progenitor cells to the cell killing effect of ionizing radiation may be attributed to a failure to induce a subset of radioprotective cytokines in the immature bone marrow microenvironment.

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Effects of Early Therapeutic Administration of Interleukin-1β on Survival Rate and Bone Marrow Hemopoiesis of Irradiated Mice

Cited by 3 publications

References 4 publications

Radioprotective Effect of Heparin

Radioprotective Effect of Heparin

A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice

Age Dependence of Hematopoietic Progenitor Survival and Chemokine Family Gene Induction after Gamma Irradiation in Bone Marrow Tissue in C3H/He Mice

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