Effects of early life stress on cocaine self-administration in post-pubertal male and female rhesus macaques

Wakeford, Alison G.P.; Morin, Elyse; Bramlett, Sara N; Howell, Brittany R.; McCormack, Kai M.; Meyer, Jerrold S.; Nader, Michael A.; Sánchez, Mar M.; Howell, Leonard L.

doi:10.1007/s00213-019-05254-8

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…Functional changes that occur in the DA system as a result of ELS may also be associated with altered neurochemical and behavioral responses to drug abuse. Early life stress may lead to enhanced DA and behavioral responses to psychostimulants and changes in drug consumption patterns that reflect greater vulnerability for drug abuse in later life in animals [275,290,297,298,[305][306][307][308][309]. The first evidence that some of these findings may translate to humans was provided by findings of an [ 11 C]raclopride positron emission tomography (PET) study conducted by Pruessner and colleagues [310], who found that persons who reported low maternal care had greater VS DA release in response to stress than individuals who reported high maternal care.…”

Section: Effects Of Els On Dopamine Functionmentioning

confidence: 99%

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Oswald

Dunn

Seminowicz

et al. 2021

JPM

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A robust body of research has shown that traumatic experiences occurring during critical developmental periods of childhood when neuronal plasticity is high increase risks for a spectrum of physical and mental health problems in adulthood, including substance use disorders. However, until recently, relatively few studies had specifically examined the relationships between early life stress (ELS) and opioid use disorder (OUD). Associations with opioid use initiation, injection drug use, overdose, and poor treatment outcome have now been demonstrated. In rodents, ELS has also been shown to increase the euphoric and decrease antinociceptive effects of opioids, but little is known about these processes in humans or about the neurobiological mechanisms that may underlie these relationships. This review aims to establish a theoretical model that highlights the mechanisms by which ELS may alter opioid sensitivity, thereby contributing to future risks for OUD. Alterations induced by ELS in mesocorticolimbic brain circuits, and endogenous opioid and dopamine neurotransmitter systems are described. The limited but provocative evidence linking these alterations with opioid sensitivity and risks for OUD is presented. Overall, the findings suggest that better understanding of these mechanisms holds promise for reducing vulnerability, improving prevention strategies, and prescribing guidelines for high-risk individuals.

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Section: Effects Of Els On Dopamine Functionmentioning

confidence: 99%

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Oswald

Dunn

Seminowicz

et al. 2021

JPM

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“…This pattern has been observed in a monetary incentive delay task designed to distinguish between reward anticipation and consumption (Boecker et al., 2014). More generally, it concords with wide‐spread findings that early life adversity impairs cue‐reward learning (Birn et al., 2017; Dennison et al., 2019; Dillon et al., 2009; Stuart, Hinchcliffe, & Robinson, 2019) while increasing sensitivity to dopamine‐releasing drugs (Cruz, Quadros, Planeta, & Miczek, 2008; Kosten, Miserendino, & Kehoe, 2000; Kosten, Sanchez, Zhang, & Kehoe, 2004; Kosten, Zhang, & Kehoe, 2006; Paine et al., 2021; Wakeford et al., 2019; Zhang, Sanchez, Kehoe, & Kosten, 2005).…”

Section: Resultsmentioning

confidence: 99%

“…2000; Kosten, Sanchez, Zhang, & Kehoe, 2004;Kosten, Zhang, & Kehoe, 2006;Paine et al, 2021;Wakeford et al, 2019;Zhang, Sanchez, Kehoe, & Kosten, 2005).…”

Section: Post Critical Periodmentioning

confidence: 99%

Interval Timing as a Computational Pathway From Early Life Adversity to Affective Disorders

Harhen,

Bornstein

2023

Topics in Cognitive Science

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Adverse early life experiences can have remarkably enduring negative consequences on mental health, with numerous, varied psychiatric conditions sharing this developmental origin. Yet, the mechanisms linking adverse experiences to these conditions remain poorly understood. Here, we draw on a principled model of interval timing to propose that statistically optimal adaptation of temporal representations to an unpredictable early life environment can produce key characteristics of anhedonia, a transdiagnostic symptom associated with affective disorders like depression and anxiety. The core observation is that early temporal unpredictability produces broader, more imprecise temporal expectations. As a result, reward anticipation is diminished, and associative learning is slowed. When agents with such representations are later introduced to more stable environments, they demonstrate a negativity bias, responding more to the omission of reward than its receipt. Increased encoding of negative events has been proposed to contribute to disorders with anhedonia as a symptom. We then examined how unpredictability interacts with another form of adversity, low reward availability. We found that unpredictability's effect was most strongly felt in richer environments, potentially leading to categorically different phenotypic expressions. In sum, our formalization suggests a single mechanism can help to link early life adversity to a range of behaviors associated with anhedonia, and offers novel insights into the interactive impacts of multiple adversities.

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Effects of early life stress on cocaine intake in male and female rhesus macaques

et al. 2020

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Effects of early life stress on cocaine self-administration in post-pubertal male and female rhesus macaques

Cited by 4 publications

References 56 publications

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Interval Timing as a Computational Pathway From Early Life Adversity to Affective Disorders

Effects of early life stress on cocaine intake in male and female rhesus macaques

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