Effects of early-life gut microbiota on the neurodevelopmental outcomes of preterm infants: a multi-center, longitudinal observational study in China

Zhang, Dan; Lan, Yancong; Zhang, Jun; Cao, Mi; Yang, Xinyi; Wang, Xia

doi:10.1007/s00431-024-05423-8

Eur J Pediatr

2024

DOI: 10.1007/s00431-024-05423-8

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Effects of early-life gut microbiota on the neurodevelopmental outcomes of preterm infants: a multi-center, longitudinal observational study in China

Dan Zhang,

Yancong Lan,

Jun Zhang

et al.

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2024

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Cited by 3 publications

References 29 publications

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Response to correspondence: ‘Why do children with oesophageal atresia have attention problems: complications should be considered’

van Hal,

IJsselstijn,

Rietman

2024

Eur J Pediatr

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Response to correspondence: ‘Why do children with oesophageal atresia have attention problems: complications should be considered’

van Hal,

IJsselstijn,

Rietman

2024

Eur J Pediatr

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Exploration of the impact of dysbiosis in the gut microbiota on microbial composition in children’s neurodevelopment

Guo,

Zeng,

Lin

2024

International Journal of Neuroscience

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Microbiome and its impact on fetal and neonatal brain development: current opinion in pediatrics

Frerichs,

de Meij,

Niemarkt

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Emerging evidence suggests that the gut microbiota and its metabolites regulate neurodevelopment and cognitive functioning via a bi-directional communication system known as the microbiota-gut-brain axis (MGBA). Recent findings The MGBA influences brain development and function via the hypothalamic-pituitary axis, the vagal nerve, immune signaling, bacterial production of neurotransmitters, and microbial metabolites like short-chain fatty acids, tryptophan derivatives, and bile acids. Animal studies show fetal neurodevelopment is mediated by maternal microbiota derivatives, immune activation, and diet. Furthermore, manipulation of the microbiota during critical windows of development, like antibiotic exposure and fecal microbiota transplantation, can affect cognitive functioning and behavior in mice. Evidence from human studies, particularly in preterm infants, also suggests that a disrupted gut microbiota colonization may negatively affect neurodevelopment. Early microbial signatures were linked to favorable and adverse neurodevelopmental outcomes. Summary The link between the gut microbiota and the brain is evident. Future studies, including experimental studies, larger participant cohort studies with longitudinal analyses of microbes, their metabolites, and neurotransmitters, and randomized controlled trials are warranted to further elucidate the mechanisms of the MGBA. Identification of early, predictive microbial markers could pave the way for the development of novel early microbiota-based intervention strategies, such as targeted probiotics, and vaginal or fecal microbiota transplantation, aimed at improving infant neurodevelopment.

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Effects of early-life gut microbiota on the neurodevelopmental outcomes of preterm infants: a multi-center, longitudinal observational study in China

Cited by 3 publications

References 29 publications

Response to correspondence: ‘Why do children with oesophageal atresia have attention problems: complications should be considered’

Response to correspondence: ‘Why do children with oesophageal atresia have attention problems: complications should be considered’

Exploration of the impact of dysbiosis in the gut microbiota on microbial composition in children’s neurodevelopment

Microbiome and its impact on fetal and neonatal brain development: current opinion in pediatrics

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