Effects of early comprehensive interventions on child neurodevelopment in poor rural areas of China: a moderated mediation analysis

Liu, Siman; Wang, Z.; Zhao, Chunxia; Huang, Xiaona; Liang, Xi; Wang, X.; Lu, Shan; Scherpbier, Robert

doi:10.1016/j.puhe.2018.02.010

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…The comparative easeof-use of the screening tools and budget-related constraints related to the requirement of a trained psychologist or psychotherapist led to the decision to use the various screening tools. Nonetheless, the ASQ-III tool has been widely used in studies to assess the neurodevelopment of infants and toddlers [25][26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

In utero Zika virus exposure and neurodevelopment at 24 months in toddlers normocephalic at birth: a cohort study

Grant

Fléchelles

Tressières³

et al. 2021

BMC Med

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Background In utero exposure to Zika virus (ZIKV) is known to be associated with birth defects. The impact of in utero ZIKV exposure on neurodevelopmental outcomes in early childhood remains unclear. The objective of this study was to determine the impact of in utero ZIKV exposure on neurodevelopment at 24 months of age among toddlers who were born normocephalic to women who were pregnant during the 2016 ZIKV outbreak in French territories in the Americas. Methods We conducted a population-based mother-child cohort study of women whose pregnancies overlapped with the 2016 ZIKV epidemic in Guadeloupe, Martinique, and French Guiana. Infants were included in this analysis if maternal ZIKV infection during pregnancy could be determined, the newborn had a gestational age ≥ 35 weeks, there were no abnormal transfontanelle cerebral ultrasound findings after delivery or no abnormal ultrasound findings on the last ultrasound performed during the third trimester of the mother’s pregnancy, there was an absence of microcephaly at birth, and the parent completed the 24-month neurodevelopment assessment of the infant at 24 months (± 1 month) of age. ZIKV exposure of the toddler was determined by evidence of maternal ZIKV infection during pregnancy. Neurodevelopment assessments included the Ages and Stages Questionnaire (ASQ) for five dimensions of general development—communication, gross motor, fine motor, problem solving, and personal-social skills; the Modified Checklist for Autism on Toddlers (M-CHAT) for behavior; and the French MacArthur Inventory Scales (IFDC) for French language acquisition. Results Between June 2018 and August 2019, 156 toddlers with and 79 toddlers without in utero ZIKV exposure completed neurodevelopment assessments. Twenty-four (15.4%) ZIKV-exposed toddlers and 20 (25.3%) ZIKV-unexposed toddlers had an ASQ result below the reference − 2SD cut-off (P = 0.10) for at least one of the five ASQ dimensions. Conclusion In one of the largest population-based cohorts of in utero ZIKV-exposed, normocephalic newborns to date, there were minimal differences apparent in neurodevelopment outcomes at 24 months of age compared to ZIKV-unexposed toddlers at 24 months of age. Trial registration ClinicalTrials.gov, NCT02810210. Registered 20 June 2016.

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Section: Discussionmentioning

confidence: 99%

In utero Zika virus exposure and neurodevelopment at 24 months in toddlers normocephalic at birth: a cohort study

Grant

Fléchelles

Tressières³

et al. 2021

BMC Med

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“…Comprehensive intervention programs that include executive function training may improve early childhood development, especially in poor rural areas. 34 Strengths of the current study were that executive function training was implemented to improve the use of adaptive and maladaptive emotion regulation strategies in the preschool years. In addition, mediation analyses were conducted to examine the underlying mechanisms through which executive function training improved emotion regulation strategies.…”

Section: Mediation Analyses Of Intervention Effects On Emotion Regulation Strategiesmentioning

confidence: 99%

Cognitive training improves emotion regulation in Chinese preschool children

Xie

Liu

Fang

2021

Pediatrics International

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Background: The ability to regulate emotion effectively plays a key role in child psychosocial development and mental health. The current study examines the effect of cognitive training for executive function on emotion regulation in Chinese preschool children, and further investigate the underlying mediating mechanisms. Methods: A cluster randomized control trial design with pre-test and post-test was conducted in 61 preschool children aged 3-6 years in China. The intervention group consisted of 30 children who received eight cognitive training sessions on executive function, while the control group consisted of 31 children who did not receive any psychological training. Children's executive function was measured individually via five laboratory tasks both in the pre-test and post-test. Adaptive and maladaptive emotion regulation strategies were coded in emotion-elicit contexts. Results: Intervention group outperformed control group in working memory and inhibitory control. Children in the intervention group exhibited increased use of adaptive emotion regulation strategies and decreased use of maladaptive emotion regulation strategies than children in the control group. Mediation analyses indicated that there were significantly indirect effects of Intervention Condition on the gain scores of adaptive and maladaptive emotion regulation strategies through the gain score of inhibitory control. Conclusions: Executive function training effectively promotes working memory, inhibitory control and the use of adaptive emotion regulation strategies, and reduces the use of maladaptive emotion regulation strategies. In addition, executive function training improves the use of adaptive and maladaptive emotion regulation strategies through the enhancement of inhibitory control capacity.

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“…The infant brain is very responsive to environmental changes. Many factors, such as early-life adverse events, pubertal and maternal stress (52)(53)(54), toxins (55)(56)(57), nutrition (58)(59)(60), geographic environment (61,62), and epigenetic factors (63,64), can have adverse consequences on neurodevelopment. Indeed, there is increasing evidence that most neurological and psychiatric disorders have a developmental origin that is the result of prenatal and early postnatal disturbances in this complex process (65)(66)(67)(68)(69).…”

mentioning

confidence: 99%

How early media exposure may affect cognitive function: A review of results from observations in humans and experiments in mice

Christakis

Ramirez

Ferguson

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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Attention deficit hyperactivity disorder (ADHD) is now among the most commonly diagnosed chronic psychological dysfunctions of childhood. By varying estimates, it has increased by 30% in the past 20 years. Environmental factors that might explain this increase have been explored. One such factor may be audiovisual media exposure during early childhood. Observational studies in humans have linked exposure to fast-paced television in the first 3 years of life with subsequent attentional deficits in later childhood. Although longitudinal and well controlled, the observational nature of these studies precludes definitive conclusions regarding a causal relationship. As experimental studies in humans are neither ethical nor practical, mouse models of excessive sensory stimulation (ESS) during childhood, akin to the enrichment studies that have previously shown benefits of stimulation in rodents, have been developed. Experimental studies using this model have corroborated that ESS leads to cognitive and behavioral deficits, some of which may be potentially detrimental. Given the ubiquity of media during childhood, these findings in humansand rodents perhaps have important implications for public health.

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Effects of early comprehensive interventions on child neurodevelopment in poor rural areas of China: a moderated mediation analysis

Cited by 10 publications

References 25 publications

In utero Zika virus exposure and neurodevelopment at 24 months in toddlers normocephalic at birth: a cohort study

In utero Zika virus exposure and neurodevelopment at 24 months in toddlers normocephalic at birth: a cohort study

Cognitive training improves emotion regulation in Chinese preschool children

How early media exposure may affect cognitive function: A review of results from observations in humans and experiments in mice

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