Effects of early administration of dexamethasone, N-acetylcysteine and aprotinin on inflammatory and oxidant–antioxidant status after lung contusion in rats

Türüt, Hasan; Çıralık, Harun; Kılınç, Metin; Özbağ, Davut; Imrek, Secil Simsek

doi:10.1016/j.injury.2008.05.001

Cited by 44 publications

(50 citation statements)

References 30 publications

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“…EPO administration also resulted in lower levels of MDA, a marker of hypoxic tissue injury, compared to traumatized rats not administered EPO. Similar to the present results, Türüt et al [15] and Basaran et al [16] found significantly Groups were baseline control = uninjured and untreated, positive control = injured but untreated, erythropoietin-treated = injured and given a single dose of IP erythropoietin just after lung injury. All rats of EPO-24 group were killed at hour 24 after chest trauma.…”

Section: Discussionsupporting

confidence: 91%

“…Total tissue damage was calculated using the scoring system described above. [15] Statistical Analysis Individual group biochemical parameters were checked for normalcy of distribution prior to statistical analysis using the Shapiro-Wilk test. The Kruskal-Wallis test was used for nonnormally distributed variables, and Mann-Whitney U test was performed on biochemical data to examine differences among groups.…”

Section: Histopathological Evaluationmentioning

confidence: 99%

“…Leukocyte infiltration in the alveolar space and atelectasis have been observed at 24 hours post-contusion. [10,15] In the present study, congestion, hem-orrhage, inflammation, interstitial edema, and alveolar collapse were scored. Total tissue damage score demonstrated significant decrease with the use of EPO.…”

Section: (A) (B) (C)mentioning

confidence: 99%

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Endogenous erythropoietin level and effects of exogenous erythropoietin in a rat model of blunt chest trauma -induced pulmonary contusion

Bakan¹,

Kurutaş

Çıralık

et al. 2015

Ulus Travma Acil Cerrahi Derg

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Section: Discussionsupporting

confidence: 91%

Section: Histopathological Evaluationmentioning

confidence: 99%

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Endogenous erythropoietin level and effects of exogenous erythropoietin in a rat model of blunt chest trauma -induced pulmonary contusion

Bakan¹,

Kurutaş

Çıralık

et al. 2015

Ulus Travma Acil Cerrahi Derg

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“…This then leads to ventilation-perfusion mismatch and worsening of gas exchange, as shown by Türüt et al (21) in a rat traumatic contusion model. Regarding the blood gas analysis in our study, the values of blood gases, except pCO 2 , in the vitamin C-treated contused group (group 4) were similar to those of the noncontused group (group 1) on day 3.…”

Section: Alveolar Edema and Congestionmentioning

confidence: 86%

Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model

Sirmali

Giniş²,

Sırmalı

et al. 2014

Turk J Med Sci

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Background/aim: To analyze the protective activity of vitamin C on the lungs by assessing biochemical and histopathological analysis after performing an experimental isolated lung contusion model. Materials and methods:Fifty-four male Sprague-Dawley male rats were used. The rats were randomly separated into 4 groups. Vitamin C (200 mg/kg) was injected intraperitoneally 30 min after trauma. Blood samples were obtained for myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities and malondialdehyde (MDA) levels. Blood gas analysis and bronchoalveolar lavage was performed. The lung tissue was also extracted for histopathological examination. Results:The lung contusion enhanced MDA, SOD, CAT, and MPO and diminished GSH-Px. Vitamin C administration after the pulmonary contusion was found to diminish the level of MDA and the activities of SOD, CAT, and MPO and to enhance the level of GSH-Px (P < 0.05). Contusion-induced disrupted gas analysis and leukocyte infiltration were both resolved by the vitamin C. Conclusion:The present results indicate that vitamin C administration attenuated the oxidative damage and morphological changes induced by pulmonary contusion in an experimental rat study.

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“…MDA is a good indicator of free radical production. Turut et al demonstrated that MDA levels increased as a marker of oxidative stress in a pulmonary contusion model (31). In another study, IMA and MDA activities were tested in a rat testicular torsion model.…”

Section: Discussionmentioning

confidence: 98%

Role of ischemic modified albumin in the early diagnosis of increased intracranial pressure and brain death

Kara¹,

Pampal²,

Yıldırım³

et al. 2017

BLL

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AIM: Increased intracranial pressure following trauma and subsequent possible development of brain death are important factors for morbidity and mortality due to ischemic changes. We aimed to establish the role of ischemic modifi ed albumin (IMA) in the early diagnosis of the process, starting with increased intracranial pressure and ending with brain death. MATERIALS AND METHODS: Eighteen Wistar-Albino rats were divided into three groups; control (CG, n = 6), increased intracranial pressure (ICPG, n = 6), and brain death (BDG, n = 6). Intracranial pressure elevation and brain death were constituted with the infl ation of a balloon of a Fogarty catheter in the epidural space. In all three groups, blood samples were drawn before the procedure, and at minutes 150 and 240 for IMA and malondialdehyde (MDA) analysis. RESULTS: Serum IMA levels at 150 and 240 minutes were higher in ICPG than in CG (p < 0.05). IMA levels were similar in ICPG and BDG. Serum MDA levels at 150 and 240 minutes increased in ICPG and BDG groups compared to CG (p < 0.05). MDA levels were similar in ICP and BD groups. CONCLUSION: IMA should be considered as a biochemical parameter in the process starting from increased intracranial pressure elevation and ending at brain death (Tab. 3, Fig. 5, Ref. 31). Text in PDF www.elis.sk. KEY WORDS: ischemic modifi ed albumin, increased intracranial pressure, brain death.

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Effects of early administration of dexamethasone, N-acetylcysteine and aprotinin on inflammatory and oxidant–antioxidant status after lung contusion in rats

Cited by 44 publications

References 30 publications

Endogenous erythropoietin level and effects of exogenous erythropoietin in a rat model of blunt chest trauma -induced pulmonary contusion

Endogenous erythropoietin level and effects of exogenous erythropoietin in a rat model of blunt chest trauma -induced pulmonary contusion

Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model

Role of ischemic modified albumin in the early diagnosis of increased intracranial pressure and brain death

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