2008
DOI: 10.1002/jps.21343
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Effects of E. Coli lipopolysaccharide on the pharmacokinetics of ipriflavone and its metabolites, M1 and M5, after intravenous and oral administration of ipriflavone to rats: Decreased metabolism of ipriflavone due to decreased expression of hepatic CYP1A2 and 2C11

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Cited by 7 publications
(8 citation statements)
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“…The results of the in vitro metabolism studies showed the different influences of LPS on hepatic and intestinal drug-metabolizing enzymes. LPS pretreatment was reported to show different influences on the expression of cytochromes P450 in the liver and intestine (Chung et al, 2008), which might be related to the tissuespecific concentrations of the effectors and the severity of pathological changes. The absence of LPS modulation of hepatic metabolism in the current work might have been caused by the different experimental settings, especially the time of initiation of the experiment after LPS administration.…”
Section: Discussionmentioning
confidence: 99%
“…The results of the in vitro metabolism studies showed the different influences of LPS on hepatic and intestinal drug-metabolizing enzymes. LPS pretreatment was reported to show different influences on the expression of cytochromes P450 in the liver and intestine (Chung et al, 2008), which might be related to the tissuespecific concentrations of the effectors and the severity of pathological changes. The absence of LPS modulation of hepatic metabolism in the current work might have been caused by the different experimental settings, especially the time of initiation of the experiment after LPS administration.…”
Section: Discussionmentioning
confidence: 99%
“…The procedures used for the measurement of V max (the maximum velocity) and K m (apparent Michaelis-Menten constant; the concentration at which the rate is one-half of the V max ) for the disappearance of ipriflavone in hepatic microsomes (n 5 6, each) were similar to a reported method [23]. The above microsomes (equivalent to 0.5 mg proteins), 5 ml of methanol containing ipriflavone at final concentrations of 0.5, 1, 2, 5, 10, 20 and 50 mM, and 50 ml of 0.1 M phosphate buffer (pH 7.4) containing 1 mM NADPH were used.…”
Section: Preparation Of Rat Hepatic and Intestinal Microsomesmentioning
confidence: 99%
“…The procedures used for pretreatments of rats including cannulation (early in the morning) of the carotid artery (for blood sampling) and the jugular vein (for drug administration in the intravenous study) were similar to reported methods [2,3,7,20,21,23].…”
Section: Intravenous and Oral Administration Of Ipriflavone To Ratsmentioning
confidence: 99%
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