Effects of dynamic mechanical stimulations on the regeneration of in vitro and in vivo cartilage tissue based on silk fibroin scaffold

Gu, Minjing; Fan, Suna; Zhou, Guangdong; Ma, Kai; Yao, Xiang; Zhang, Yaopeng

doi:10.1016/j.compositesb.2022.109764

Cited by 36 publications

(11 citation statements)

References 57 publications

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“…(d) Modulus of brain, 68 spinal cord, 88 muscles, 107 and cartilage. 108 verified in terms of the growth and neurite extension of neural cells. 120,121 Previous studies have shown that the moduli of SF films could be tailored by changing the crystallinity (e.g., by alcohol induction or water annealing).…”

Section: Silk Fibroinmentioning

confidence: 89%

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Bioactive polymer-enabled conformal neural interface and its application strategies

Niu

Hsiao

et al. 2023

Mater. Horiz.

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Section: Silk Fibroinmentioning

confidence: 89%

“…All the columns in the boxes represent a general range. (d) Modulus of brain,68 spinal cord,88 muscles,107 and cartilage 108.…”

mentioning

confidence: 99%

Bioactive polymer-enabled conformal neural interface and its application strategies

Niu

Hsiao

et al. 2023

Mater. Horiz.

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“…Briefly, the total RNA of indicated samples were isolated by MagneSil @ Total RNA mini-isolation system through recommended procedures [ 52–54 ] after 4 days of cell culture. Following cDNA synthesis and quantitative fluorescence testing by Shanghai Daixuan Biotechnology Co., Ltd, data were analyzed using the 2 −ΔΔCt method, and β -actin was chosen as the housekeeping gene [ 55 , 56 ]. The primers of the osteogenic characteristic and housekeeping genes used in this study are listed in Table 1 .…”

Section: Experiments and Methodsmentioning

confidence: 99%

Fiber diameters and parallel patterns: proliferation and osteogenesis of stem cells

Fan

Kundu

et al. 2023

Regenerative Biomaterials

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Due to the innate extracellular matrix mimicking features, fibrous materials exhibited great application potential in biomedicine. In developing excellent fibrous biomaterial, it is essential to reveal the corresponding inherent fiber features' effects on cell behaviors. Due to the inevitable “interference” cell adhesions to the background or between adjacent fibers, it is difficult to precisely reveal the inherent fiber diameter effect on cell behaviors by using a traditional fiber mat. A single-layer and parallel-arranged polycaprolactone fiber pattern platform with an excellent non-fouling background is designed and constructed herein. In this unique material platform, the “interference” cell adhesions through interspace between fibers to the environment could be effectively ruled out by the non-fouling background. The “interference” cell adhesions between adjacent fibers could also be excluded from the sparsely arranged (SA) fiber patterns. The influence of fiber diameter on stem cell behaviors is precisely and comprehensively investigated based on eliminating the undesired “interference” cell adhesions in a controllable way. On the SA fiber patterns, small diameter fiber (SA-D1, D1 means one μm in diameter) may seriously restrict cell proliferation and osteogenesis when compared to the middle (SA-D8) and large (SA-D56) ones and SA-D8 shows the optimal osteogenesis enhancement effect. At the same time, the cells present similar proliferation ability and even the highest osteogenic ability on the densely arranged (DA) fiber patterns with small diameter fiber (DA-D1) when compared to the middle (DA-D8) and large (DA-D56) ones. The “interference” cell adhesion between adjacent fibers under dense fiber arrangement may be the main reason for inducing these different cell behavior trends along with fiber diameters. Related results and comparisons have illustrated the effects of fiber diameter on stem cell behaviors more precisely and objectively, thus providing valuable reference and guidance for developing effective fibrous biomaterials.

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“…In this review, we are more focused on its unique application in the fields of cell-material interactions, soft tissue engineering, and flexible bioelectronic devices. As for the other important biomedical applications, such as wound dressing, hard tissue engineering and drug delivery etc ., extensive descriptions could be seen from previous publications [ 28 , 29 , [109] , [110] , [111] , [112] , [113] , [114] , [115] , [116] , [117] ].…”

Section: Advanced Biomedical Applications Of Rsf Materialsmentioning

confidence: 99%

Bioinspired silk fibroin materials: From silk building blocks extraction and reconstruction to advanced biomedical applications

Yao

Zou

Fan

et al. 2022

Materials Today Bio

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Effects of dynamic mechanical stimulations on the regeneration of in vitro and in vivo cartilage tissue based on silk fibroin scaffold

Cited by 36 publications

References 57 publications

Bioactive polymer-enabled conformal neural interface and its application strategies

Bioactive polymer-enabled conformal neural interface and its application strategies

Fiber diameters and parallel patterns: proliferation and osteogenesis of stem cells

Bioinspired silk fibroin materials: From silk building blocks extraction and reconstruction to advanced biomedical applications

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