Effects of Dust Storm Fine Particle-Inhalation on the Respiratory, Cardiovascular, Endocrine, Hematological, and Digestive Systems of Rats

Cao, Xiao-Jun; Lei, Feng-Feng; Liu, Hua; Luo, Wenhao; Xiao, Xiao-Hui; Li, Yang; Lu, Junfeng; Dong, Zhen; Chen, Qizhang

doi:10.4103/0366-6999.243571

Cited by 11 publications

(6 citation statements)

References 13 publications

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“…One of the few animal studies to employ an inhalation exposure examined systemic toxicity (respiratory, cardiovascular, endocrine and digestive systems) of PM collected from the Alxa Plateau of Inner Mongolia by simulating a real dust storm environment using a wind tunnel system ( Cao et al 2018 ). Rats were exposed to 9000 μg/m 3 for 5 h each day and sacrificed on day 45, 90, 135 or 180.…”

Section: Resultsmentioning

confidence: 99%

Mechanisms underlying the health effects of desert sand dust

Fussell

Kelly

2021

Environment International

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Highlights 52 studies investigating mechanisms behind impacts of desert dust on health are reviewed. Desert dust may be a risk factor for inflammatory and allergic lung diseases. Adhered chemicals, biological and mineralogical components are candidate activators. Desert dust surface reactions may enhance toxicity of aerosols in urban environments.

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Section: Resultsmentioning

confidence: 99%

Mechanisms underlying the health effects of desert sand dust

Fussell

Kelly

2021

Environment International

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“…Similarly, dust particles are associated with the onset of circulatory diseases 29 , 30 . The association of SDS events exposure with overall circulatory morbidity and mortality seemed pathologically plausible; for example, Cao et al’s study showed an increase in circulating inflammatory cytokines and enzymes with rats’ repeated exposure to fine dust particles 31 . Yet, little is known regarding how SDS exposure affects mortality due to cause-specific circulatory diseases.…”

Section: Discussionmentioning

confidence: 99%

“…By collecting blood and urine samples from people affected by the dust storm, Badeenezhad et al measured biomarkers related to the central nervous system and found that PM 10 during SDS could cause neuron and astrocyte damage, leading to neuropsychiatric disorders 37 . Cao et al found that repeated exposure to fine dust particles could cause pathological changes in the stomach of rats 31 . Our study results and previous findings provide evidence suggesting the potentially harmful impact of SDS events on mortality due to genitourinary, nervous, and digestive system diseases.…”

Section: Discussionmentioning

confidence: 99%

Mortality risks from a spectrum of causes associated with sand and dust storms in China

Zhang,

Yan,

et al. 2023

Nat Commun

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Sand and Dust Storms (SDS) pose considerable health risks worldwide. Previous studies only indicated risk of SDS on overall mortality. This nationwide multicenter time-series study aimed to examine SDS-associated mortality risks extensively. We analyzed 1,495,724 deaths and 2024 SDS events from 1 February to 31 May (2013–2018) in 214 Chinese counties. The excess mortality risks associated with SDS were 7.49% (95% CI: 3.12–12.05%), 5.40% (1.25–9.73%), 4.05% (0.41–7.83%), 3.45% (0.34–6.66%), 3.37% (0.28–6.55%), 3.33% (0.07–6.70%), 8.90% (4.96–12.98%), 12.51% (6.31–19.08%), and 11.55% (5.55–17.89%) for ischemic stroke, intracerebral hemorrhagic stroke, hypertensive heart disease, myocardial infarction, acute myocardial infarction, acute ischemic heart disease, respiratory disease, chronic lower respiratory disease, and chronic obstructive pulmonary disease (COPD), respectively. SDS had significantly added effects on ischemic stroke, chronic lower respiratory disease, and COPD mortality. Our results suggest the need to implement public health policy against SDS.

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“…This results in the transport of PM with the wind [2,3]. Prolonged exposure to PM results in adverse effects on human health, particularly on normal lung function, by inducing inflammation and oxidative stress in lung cells [4,5]. The inhalation of PM depends on its penetration depth, deposition, particle size, shape, and density [6].…”

Section: Introductionmentioning

confidence: 99%

“…The inhalation of PM depends on its penetration depth, deposition, particle size, shape, and density [6]. The World Health Organization (WHO) reported that PM exposure was responsible for more than seven billion deaths in 2012, whereas the American Cancer Society indicated that the rise in PM increased the total death rate by 7% [5,7,8].…”

Section: Introductionmentioning

confidence: 99%

Eckmaxol Isolated from Ecklonia maxima Attenuates Particulate-Matter-Induced Inflammation in MH-S Lung Macrophage

et al. 2022

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Airborne particulate matter (PM) originating from industrial processes is a major threat to the environment and health in East Asia. PM can cause asthma, collateral lung tissue damage, oxidative stress, allergic reactions, and inflammation. The present study was conducted to evaluate the protective effect of eckmaxol, a phlorotannin isolated from Ecklonia maxima, against PM-induced inflammation in MH-S macrophage cells. It was found that PM induced inflammation in MH-S lung macrophages, which was inhibited by eckmaxol treatment in a dose-dependent manner (21.0–84.12 µM). Eckmaxol attenuated the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in PM-induced lung macrophages. Subsequently, nitric oxide (NO), prostaglandin E-2 (PGE-2), and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) were downregulated. PM stimulated inflammation in MH-S lung macrophages by activating Toll-like receptors (TLRs), nuclear factor-kappa B (NF-κB), and mitogen-activated protein kinase (MAPK) pathways. Eckmaxol exhibited anti-inflammatory properties by suppressing the activation of TLRs, downstream signaling of NF-κB (p50 and p65), and MAPK pathways, including c-Jun N-terminal kinase (JNK) and p38. These findings suggest that eckmaxol may offer substantial therapeutic potential in the treatment of inflammatory diseases.

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Effects of Dust Storm Fine Particle-Inhalation on the Respiratory, Cardiovascular, Endocrine, Hematological, and Digestive Systems of Rats

Cited by 11 publications

References 13 publications

Mechanisms underlying the health effects of desert sand dust

Mechanisms underlying the health effects of desert sand dust

Mortality risks from a spectrum of causes associated with sand and dust storms in China

Eckmaxol Isolated from Ecklonia maxima Attenuates Particulate-Matter-Induced Inflammation in MH-S Lung Macrophage

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