Effects of duodenogastric reflux on gastrin cells, somatostatin cells and serotonin cells in human antral gastric mucosa

Tzaneva, Maria

doi:10.1016/j.prp.2004.04.002

Cited by 6 publications

(7 citation statements)

References 36 publications

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“…24 However, prior studies have suggested that endoscopy has decreased accuracy and a lower positive predictive value when compared to other methods, such as hepatobiliary scintigraphy, further contributing to the missed diagnosis. 6,[29][30][31] The prevalence of motility disorders was similar to those seen in previous studies of functional dyspepsia, with approximately one third of patients showing delayed gastric emptying. 2,32 The lack of significant delay in gastric emptying, especially in the BG group suggests that a primary gastric emptying/motility problem is unlikely to be an important mechanism and that excess duodenogastric bile reflux is the key driver for this problem.…”

Section: Discussionsupporting

confidence: 74%

“…NSAID-induced chemical gastropathy is however indistinguishable from BG histologically, and is clearly one limitation that may contribute to the under recognition of BG. 29 Another limitation is that most endoscopists may not recognize or document duodenogastric bile reflux. We used the presence of bile in the stomach as an endoscopic marker for duodenogastric reflux, as it can be easily identified during endoscopy.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bile Reflux Gastropathy and Functional Dyspepsia

Lake

Rao

Larion

et al. 2021

J Neurogastroenterol Motil

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Background/AimsThe pathoetiology of functional dyspepsia remains unclear; one mechanism could be chemical gastropathy from chronic bile reflux. We aim to examine the association of bile reflux gastropathy with functional dyspepsia and identify predisposing factors. MethodsIn a retrospective study, patients with functional dyspepsia (Rome III) who completed symptom assessment, esophagogastroduodenoscopy, and biopsies were categorized into 3 groups; bile gastropathy (BG), non-bile gastropathy (NBG), and no gastropathy (NG). Demographics, symptoms, endoscopy, and motility data were compared between groups. Multivariate analysis identified clinical factors associated with BG. ResultsOf 262 patients (77.5% female), 90 had BG, 121 had NBG, and 51 had NG. Baseline demographics were similar, however, patients with BG reported significantly more severe abdominal pain than NBG or NG groups (P = 0.018). Gastric erythema was significantly more common in BG vs NBG groups (P < 0.001). Cholecystectomy was significantly associated (OR, 6.6; P = 0.003) with the presence of gastropathy in BG compared to NBG or NG group. Patients with cholecystectomy had significantly more severe abdominal pain (P < 0.05), gastric erythema (P < 0.03), and gastritis (P < 0.05), and were more likely to be prescribed narcotic medications (P < 0.004) than patients without cholecystectomy. ConclusionsBile reflux gastropathy is associated with functional dyspepsia and causes more severe symptoms. Cholecystectomy predisposes to BG and abnormal pain, and could contribute to the pathogenesis of functional dyspepsia.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Bile Reflux Gastropathy and Functional Dyspepsia

Lake

Rao

Larion

et al. 2021

J Neurogastroenterol Motil

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“…One possible explanation could be that DRG, which damages the gastric mucosa by bile acids and pancreatic phospholipase A2, leads to peptic ulcers 20 21 . In addition, some animal studies demonstrated that DGR suppresses somatostatin concentrations and increases intragastric gastrin and acid secretion 18 22 23 24 25 26 . Therefore, DGR may be considered a factor in the pathogenesis of gastric and duodenal ulcers as suggested by some researchers 18 30 31 .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, studies demonstrated that DGR may suppress the somatostatin concentration that is produced by the alkaline nature or pancreatic component of the reflux, which subsequently results in hypersecretion of acid and hypergastrinemia 18 22 23 24 . DGR may therefore be considered a common factor in the pathogenesis of gastric and duodenal ulcers 23 24 25 26 .…”

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confidence: 99%

Increased Risk of Peptic Ulcers Following a Cholecystectomy for Gallstones

Tsai

Huang

Lin

et al. 2016

Sci Rep

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This retrospective cohort study examined the relationship between a cholecystectomy and the subsequent risk of peptic ulcers using a population-based database. Data for this study were retrieved from the Taiwan Longitudinal Health Insurance Database 2005. This study included 5209 patients who had undergone a cholecystectomy for gallstones and 15,627 sex- and age-matched comparison patients. We individually tracked each patient for a 5-year period to identify those who subsequently received a diagnosis of peptic ulcers. We found that of the 20,836 sampled patients, 2033 patients (9.76%) received a diagnosis of peptic ulcers during the 5-year follow-up period: 674 from the study group (12.94% of the patients who underwent a cholecystectomy) and 1359 from the comparison group (8.70% of the comparison patients). The stratified Cox proportional hazard regressions showed that the adjusted hazard ratio (HR) for peptic ulcers during the 5-year follow-up period was 1.48 (95% CI = 1.34~1.64) for patients who underwent a cholecystectomy than comparison patients. Furthermore, the adjusted HRs of gastric ulcers and duodenal ulcers during the 5-year follow-up period were 1.70 and 1.71, respectively, for patients who underwent a cholecystectomy compared to comparison patients. This study demonstrated a relationship between a cholecystectomy and a subsequent diagnosis of peptic ulcers.

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Avaliação das alterações em pH gástrico e concentrações de gastrina em equinos submetidos à anestesia geral inalatória e decúbito dorsal

Guerrero¹

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Avaliação das alterações em ph gástrico e concentrações de gastrina em equinos submetidos à anestesia geral inalatória e decúbito dorsal Exame de dissertação apresentado à Faculdade de Zootecnia e Engenharia de Alimentos da Universidade de São Paulo, como parte dos requisitos para obtenção do título de Mestre em ciências do programa de pós-graduação em Biociência Animal Data de aprovação: 06/ 12/ 2021

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Effects of duodenogastric reflux on gastrin cells, somatostatin cells and serotonin cells in human antral gastric mucosa

Cited by 6 publications

References 36 publications

Bile Reflux Gastropathy and Functional Dyspepsia

Bile Reflux Gastropathy and Functional Dyspepsia

Increased Risk of Peptic Ulcers Following a Cholecystectomy for Gallstones

Avaliação das alterações em pH gástrico e concentrações de gastrina em equinos submetidos à anestesia geral inalatória e decúbito dorsal

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