Effects of drying methods on the physicochemical and compressional characteristics of Okra powder and the release properties of its metronidazole tablet formulation

Abstract

A study has been made of the effects of sun and oven drying methods on the physicochemical characteristics and compressibility of Okra powder and the release properties of its metronidazole tablet formulation. Corn starch was used as the reference standard. The mechanical properties of the tablets were evaluated using crushing strength and friability, while the release properties were determined using the disintegration times and dissolution rates. The results obtained showed that sun-dried Okra powder had smaller particle size, exhibited good flow and possessed higher hydration and swelling capacities compared to the oven dried samples. The compressibility of Okra powders assessed by the indices of plasticity from Heckel (Py) and Kawakita plots (Pk) showed that sun dried Okra powders had higher Py but lower Pk values than the oven-dried Okra powder. Metronidazole tablets formulated with oven dried Okra powder formed stronger tablets than tablets containing sun dried Okra powder. Generally, tablets containing sun dried Okra powders had faster disintegration and dissolution than tablets formulated with oven-dried powder. The results suggest that the choice of drying method during the processing of pharmaceutical raw materials is critical to its physicochemical properties and the release properties of its tablet formulations.

Nutritional Quality and Health Benefits of Okra (Abelmoschus esculentus): A Review

“…If you suffer from regular nosebleeds, bleeding gums, heavy menstrual bleeding, or easy bruising, your blood might be too thin. Consider adding more vitamin K-rich foods like okra to your diet to improve your blood's ability to coagulate (Bakre & Jaiyeoba, 2009). Okra is used to promotes a healthy of the pregnancy.…”

Influence of pregelatinization on the physicochemical and compressional characteristics of starches obtained from two local varieties of Dioscorea rotundata

“…It is also notable that gbongi starch generally exhibited the lowest Py values, whereas Efuru starch generally exhibited the highest Py values. The relative density of the powder bed at the point when the applied pressure equals zero, D 0 , is used to describe the initial rearrangement phase of densification as a result of die filling [25]. Gbongi starch generally exhibited higher degree of initial packing in the die as a result of die filling.…”

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“…Besides it is now used as a medium for several other drug deliveries. Bakre and Jaiyeoba (2009) 72 used it as metronidazole tablet formulation. Sharma, Kulkarni, and Sharma, (2013a) 73 used it in the development mucoadhesive gel for nasal delivery of rizatriptan benzoate.…”