Effects of Dry Anæsthetic Gases on the Respiratory Mucous Membrane

Burton, J.D.K.

doi:10.1016/s0140-6736(62)91187-x

Cited by 104 publications

(45 citation statements)

References 5 publications

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“…Gases delivered through an endotracheal tube must be humidified because dry inspired gases have deleterious effects [13,14,15,16]. NIV can be delivered with various kinds of ventilators, with or without gas pressurization.…”

Section: Introductionmentioning

confidence: 99%

Effect of the humidification device on the work of breathing during noninvasive ventilation

et al. 2002

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Section: Introductionmentioning

confidence: 99%

Effect of the humidification device on the work of breathing during noninvasive ventilation

et al. 2002

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“…Several animal [28] and human [29] studies have shown that bronchial lesions such as inflammation, epithelial cell injury, and mucociliary clearance impairment may be present after only a few hours of mechanical ventilation with poorly humidified gas. Marfatia and Burton [30] and Marfatia et al [31] showed extensive damage in the tracheobronchial tree of rabbits that had inhaled dry gases from a tracheal tube. Toremalm et al [32] had previously shown that administration of dry gases arrested the activity of the mucociliary transport system.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Coaxial Circle Circuit with the Conventional Circle Circuit

Mızrak

Bilgi

Koruk

et al. 2011

EAJM

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Objective: The coaxial circle system helps prevent heat loss during surgery, and it also acts as a humidifier. This study aimed to compare the coaxial breathing system and the conventional system in their ability to warm and moisturize inhaled gases, and we also analyzed lung function protection and saccharin clearance time in patients who underwent tympanomastoidectomy (TMT) with the aid of these two systems. Materials and Methods:Forty adult patients of ASA physical status I-II were scheduled for elective TMT. A standard volume-dependent ventilator setting was used to establish normocapnia. The coaxial circle system was used in the treated group (n=20), whereas the conventional circuit system was used in the control group (n=20). Saccharin clearance, VC (vital capacity), FRC (functional residual capacity), FEV 1 (forced expiratory volume in 1 second), airway pressure, relative humidity and temperature of inspired gas, body temperature and adverse and hemodynamic effects were measured at different perioperative periods.Results: The relative humidity (mg H 2 O Lt -1) of inspired gas in the treated group was higher than in the control group at 5, 15, 30, 45, 60 and 90 minutes after anesthesia induction. The temperature of inspired gas (Centigrade) in the treated group was higher than in the control group (p<0.05) after 5, 10, 15, 30, 45, and 90 minutes of anesthesia. Postoperative saccharin clearance time was lower than before the operation in the treated group (p<0.05). Postoperative FRC was lower than preoperative FRC in the study and control groups (p<0.05). Conclusion:The coaxial circle system decreased postoperative saccharin clearance time and increased postoperative FRC, relative humidity and the temperature of inspired fresh gas, without any adverse perioperative effects in patients who underwent TMT.

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“…During mechanical ventilation, heating and humidification of the inspired gas is mandatory [2][3][4][5]. Because a humidifying device increases temperature and adds vapor to the dry and cool gas delivered from a ventilator, the patient's lungs are inflated with a greater volume than that delivered from the ventilator.…”

Section: Introductionmentioning

confidence: 99%